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Apr 11, 2024Open    Access

Actual Data on the Efficacy and Safety of Gemcitabine-Docetaxel as Second-Line and Beyond Treatment in Adult Patients with Metastatic Bone Sarcomas: Experience from a Single Institution

Medyouni Hajar,Chouef Jihane,Siyouri Oumaima,Chbihi Chaymae,Mhirech Samia,Amaadour Lamiae,Oualla Karima,Benbrahim Zineb,Arifi Samia,Mellas Nawfel
Osteosarcoma, the most prevalent primary malignant bone tumor in children, presents significant challenges in treatment, particularly in cases of recurrence or refractory disease. This retrospective study explores the efficacy and safety of gemcitabine-docetaxel (GD) combination therapy as second-line or later treatment in adult patients with advanced bone sarcomas. Twenty-two patients received GD, with 64% showing overall disease control. Median progression-free survival (PFS) was 5 months, and...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1111414


Mar 20, 2024Open    Access

Acute Cerebral Ischemia in Children Rare Case Related to Anxiety, Treated with Chinese Acupuncture in Dhamar Governarate Yemen

Hadi Mujlli,Salah Ali Al Shawki,Mohammed Ali Al Huthi
Acute Ischemic Stroke (AIS) is relatively rare in children, but can lead to sig-nificant morbidity and mortality. Focal neurological signs occur in three-quarters of patients, with hemiplegia are the most common for the di-agnosis. A case report describes, 10-year-old girl who presented to the emer-gency department (ED) of our neurological center in Dhamar city 100 km south to Sana’a capital city of Yemen, with the diagnosis of an acute ischemic stroke clinically and documented before and after ...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1111306


Dec 20, 2023Open    Access

Patent Ductus Arteriosus from Diagnosis to Surgical Closure: 10 Years Experience at Federal Medical Centre Abeokuta, Ogun State, Nigeria

Chinyere C. Uzodimma, Musa K. Yusuf, Saheed B. Sanni, Augustine J. Olugbemi, Emmanuel O. Onweluzo, Modupe O. Egunjobi
Introduction: Patent ductus arteriosus is a common congenital heart defect. PDA accounts for 10% - 22% of CHD in various studies conducted in Nigeria. The addition of the paediatric cardiology sub-specialty unit at Federal Medical Centre Abeokuta was in 2013, and the centre began surgical PDA ligation in 2019. The general aim is to describe the prevalence, demographics and 10-year trend of PDA cases and our experience as a recent provider of surgical PDA ligation. The study set out to describe t...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110872


Nov 24, 2023Open    Access

Myocarditis in Under-Five Children with Community-Acquired Pneumonia Using Serum Cardiac Troponin-T and Electrocardiography

Samsudeen Alao, Chinyere Uzodimma, Adebiyi Olowu
Community-acquired pneumonia (CAP) kills more under-five (U-5) children in Sub-Saharan Africa than in any other part of the world. Co-existing myocarditis and congestive cardiac failure (CCF) in the setting of CAP could play a crucial role in determining the disease outcome. The aim of the study was to evaluate myocarditis in U-5 children with CAP in the emergency room setting using cardiac troponin-T (cTnT) and electrocardiography (ECG). A hospital based cross-sectional study involving 76 child...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110894


Oct 30, 2023Open    Access

Factors Associated with Mortality of Newborns of Hypertensive Mothers in Bukavu, Democratic Republic of the Congo

Nisa Furaha Bidorho, Mambo Mwilo, Neneh Luhiriri Mwindja, John Mulindwa, Heri Bulambo, Eric Munguakonkwa Ntagereka, Omar Mukanga, Léonard Kanku Tudiakwile, Archippe Birindwa Muhandule
Hypertensive disorders of pregnancy represent the leading cause of perinatal morbidity and mortality in developing countries. Thus, the aim of this study was to evaluate the factors associated with mortality in newborns of hypertensive mothers. This is a prospective descriptive study with analytical aims, which collected 89 newborns of hypertensive mothers in the obstetric gynecology and neonatology departments of Panzi GRH from February 20, 2021 to May 20, 2022. Blood sampling from the umbilica...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110703


Sep 28, 2023Open    Access

Intussusception Prolapsed through the Anus in Infants: In Regards of 3 Cases

A. Doumbia, M. B. Daou, M. Kouyate, O. Coulibaly, B. Kamate, M. K. Djire, I. Amadou, Y. Coulibaly
Acute intestinal intussusceptions (AII) cause a telescoping of a downstream intestinal segment by the upstream intestinal segment. The diagnosis of IIA is based more on abdominal ultrasound than on the classic clinical triad, made up of paroxysmal abdominal pain crises, vomiting and rectal bleeding. IIA is characterized in our African countries by a diagnostic delay leading to a worsening of the general condition of patients. We report 3 cases of prolapsed intestinal intussusception through the ...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110597


Aug 23, 2023Open    Access

Bacteriological Profile and Antibiotic Susceptibility Pattern of Common Isolates of Neonatal Sepsis in a Tertiary Hospital from Lagos, Nigeria

Oluwadamilare Afolabi Obe, Wasiu Bamidele Mutiu, Peter Odion Ubuane, Ibrahim Oladipupo Odulate
Background: Neonatal sepsis is one of the leading causes of mortality in the neonatal intensive care unit (NICU) of most developing countries. Antibiotic resistance is rapidly becoming a challenge in the NICU, particularly in developing countries like Nigeria. Knowledge of the bacteriological agents and their antimicrobial susceptibility pattern is essential to successfully manage sepsis in the NICU. This study was designed to determine the bacteriological etiology and antibioti...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1109558


Jun 30, 2023Open    Access

Changes Experienced by Brazilian Parents of Children with Autism Spectrum Disorder in Their Work Routine and Social Life

Suely Ruiz Giolo, Yasmin Roberta Fernandes, Adilson dos Anjos
This study aimed to explore the situations and changes Brazilian parents of children with autism spectrum disorder (ASD) experience in their work routine and social life and to understand the impact of them on their well-being. The cross-sectional study sample comprised 461 parents of children with ASD who completed an online questionnaire containing multiple-choice and open-ended questions. A descriptive analysis summarized the quantitative data, while a content analysis organized and elicited ...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110314


Jun 01, 2023Open    Access

Rare Instance of Scrotal Migration of Ventriculoperitoneal Shunt: A Case Report

Nabil Chettahi, Ayoub Benjelloun Andaloussi, Othmane Alaoui, Abdelhalim Mahmoudi, Khalid Khattala, Youssef Bouabdallah
Ventriculoperitoneal (VP) shunt is used for treating hydrocephalus but it also results in many complications, the most common being hernia and hydrocele. The distal end of the ventriculoperitoneal shunt is placed in the peritoneal cavity to drain the fluid from the ventricles. The catheter has a tendency to be displaced into the scrotum due to the patent processus vaginalis (PPV). It is treated surgically by repositioning the catheter. We present the case of a 5-year-old child who was presented ...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110155


May 30, 2023Open    Access

Clinical and Parasitological Profile of Children Aged 6 - 59 Months with Uncomplicated Malaria in Bolenge, Equateur Province, Democratic Republic of the Congo

Tarcisse K. Kilara, Alain K. K. Ilunga, Gisele K. Kabengele, Cagod B. Inkale, Nene Mbanzulu, Isaac T. Woto, Christian Tshilenge, Berry I. Bongenya, Mireille Ngale, Aline B. Engo, Destin M. Mbongi, Papy Mandoko, Gauthier K. Mesia, Erick N. Kamangu
Background: Malaria is an erythropathy caused by different species of parasites of the genus Plasmodium. It is the most common parasitic disease in the world. Objective: The objective was to assess the profile of children aged 6 - 59 months with uncomplicated malaria in Bolenge, Democratic Republic of the Congo (DRC). Methods: The present study is a descriptive cross-sectional study that was carried out in children less than 59 months old with uncomplicated malaria in Bolenge, Equateur province,...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110101


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