Objective: To evaluate the potential causal relationship between 182 gut microbiota and childhood obesity by two-sample Mendelian randomization. Methods: The data source was the summary data of genome-wide association study (GWAS), and 182 intestinal microbiota contained 874 single nucleotide diversity (SNPs). The childhood obesity data contained 2,442,739 SNPs. Mendelian randomization analysis was performed using three methods: inverse variance weighting (IVW), weighted median, and MR Egger regression. Subsequently, heterogeneity test, horizontal pleiotropy test, MR PRESSO method and leave one out analysis were used to detect outliers. Outcome: IVW analysis showed that class Erysipelotrichia (OR = 0.530, 95% CI: 0.293 - 0.958, P = 0.035), family Verrucomicrobiaceae (OR = 0.475, 95% CI: 0.311 - 0.726, P = 0.001), and genus Akkermansia (OR = 0.476, 95% CI: 0.311 - 0.726, P = 0.001) and order Verrucomicrobiales (OR = 0.475, 95% CI: 0.311 - 0.726, P = 0.001) were protective factors for the development of childhood obesity, while genus Ruminiclostridium 9 (OR = 2.051, 95% CI: 1.069 - 3.932, P = 0.031) was potential risk factor for childhood obesity. Conclusion: Genus Ruminiclostridium 9 is positively correlated with childhood obesity, while class Erysipelotrichia, family Verrucomicrobiaceae, genus Akkermansia, and order Verrucomicrobiales are negatively correlated.
Cite this paper
Xu, D. and Wang, H. (2024). Two-Sample Mendelian Randomization Analysis of the Causal Relationship between Intestinal Flora and Childhood Obesity. Open Access Library Journal, 11, e2342. doi: http://dx.doi.org/10.4236/oalib.1112342.
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