Solitary neurofibromas of the palate are rare benign tumors, and their occurrence without syndromic association is even less common. We present a case of a 82-year-old patient with a painless, slow-growing lesion on the hard palate. Clinical examination and histopathological analysis confirmed the diagnosis of a non-syndromic solitary neurofibroma. Surgical excision was performed, and no recurrence was observed during the 24-month follow-up. This report emphasizes the importance of recognizing these uncommon lesions, distinguishing them from other palatal masses, and highlights the role of histopathology in definitive diagnosis.
Cite this paper
Harrizi, M. and Haitami, S. (2026). Non-Syndromic Solitary Neurofibroma of the Hard Palate: A Case Report and Literature Review. Open Access Library Journal, 13, e15521. doi: http://dx.doi.org/10.4236/oalib.1115521.
Asha Reddy, V., Shesha Prasad, R., Sri Manasa, C. and Mohanthy, L. (2021) Nonsyndromic Solitary Neurofibromas in the Oral Cavity: Case Series and Literature Review. <i>American Journal of Case Reports</i>, 22, e920674.
Broly, E., Lefevre, B., Zachar, D. and Hafian, H. (2019) Solitary Neurofibroma of the Floor of the Mouth: Rare Localization at Lingual Nerve with Intraoral Excision. <i>BMC</i> <i>Oral</i> <i>Health</i>, 19, Article No. 197. <br>https://doi.org/10.1186/s12903-019-0888-0
Pollack, R.P. (1990) Neurofibroma of the Palatal Mucosa. a Case Report. <i>Journal</i> <i>of</i> <i>Periodontology</i>, 61, 456-458. <br>https://doi.org/10.1902/jop.1990.61.7.456
Shimoyama, T., Kato, T., Nasu, D., Kaneko, T., Horie, N. and Ide, F. (2002) Solitary Neurofibroma of the Oral Mucosa: A Previously Undescribed Variant of Neurofibroma. <i>Journal</i> <i>of</i> <i>Oral</i> <i>Science</i>, 44, 59-63. <br>https://doi.org/10.2334/josnusd.44.59
Bakshi, S., Priya, M., Coumare, V., Vijayasundaram, S. and Latheef, M. (2016) Solitary Extraosseous Neurofibroma of Hard Palate: Report of a Case with a Review of Literature. <i>Journal</i> <i>of</i> <i>Dental</i> <i>and</i> <i>Allied</i> <i>Sciences</i>, 5, 95-97. <br>https://doi.org/10.4103/2277-4696.192971
Sekhar, P., Nandhini, G., Kumar, K. and Kumar, A. (2019) Solitary Neurofibroma of the Palate Mimicking Mucocele: A Rare Case Report. <i>Journal</i> <i>of</i> <i>Oral</i> <i>and</i> <i>Maxillofacial</i> <i>Pathology</i>, 23, 23-26. <br>https://doi.org/10.4103/jomfp.jomfp_196_18
Mahalle, A., Reddy, M.G., Mohit Kheur, S., <i>et al</i>. (2016) Solitary Non-Syndromic Oral Plexiform Neurofibroma: A Case Report and Review of Literature. <i>Journal of Dentistry </i>(<i>Shiraz</i>), 17, 293-296.
Mazzoleni, S., Stomaci, D., Rizzo, A., Rigo, L., Bressan, E. and Stellini, E. (2009) Solitary Neurofibroma of the Palate: A Case Report. <i>Minerva </i><i>Stomatologica</i>, 58, 453-458.
Taketomi, T., Nakamura, K., Teratani, Y., Matsuo, K. and Kusukawa, J. (2021) Solitary Neurofibroma of the Hard Palate: A Case Report and Literature Review. <i>American</i> <i>Journal</i> <i>of</i> <i>Case</i> <i>Reports</i>, 22, e929674. <br>https://doi.org/10.12659/ajcr.929674
Alrazzouk, M.H., Mohamed, M.A.M. and Mohamed, K.E.O. (2025) Rare Solitary Neurofibroma of the Palate in a Pediatric Patient: A Case Report. <i>Annals</i> <i>of</i> <i>Dentistry</i>, 32, 18-22. <br>https://doi.org/10.22452/adum.vol32.4