Oral Leukopakia Treated with Diode Laser: Case Report and Literature Review

Proliferative verrucous leukoplakia (PVL) is a rare and aggressive form of multifocal oral lesion characterized by slow progression, resistance to treatment, and a high rate of malignant transformation. This case report describes a 70-year-old female patient presenting with a six-year history of asymptomatic multiple white oral lesions. She reported no history of tobacco or alcohol use but had been wearing an ill-fitting removable denture and using a plant-based mouthwash on a daily basis. Clinical examination revealed multiple verrucous, non-scrapable, painless lesions of inhomogeneous thickness, located on the lateral border of the tongue, the floor of the mouth, and the alveolar ridge. A biopsy confirmed the diagnosis of oral leukoplakia without dysplasia, and the clinical-pathological correlation supported the diagnosis of PVL. Management included therapeutic education, elimination of local irritants, and two sessions of diode laser ablation. At five months, the patient remains clinically stable, with complete resolution of the tongue lesion and no signs of recurrence or malignant transformation. The aim of this report is to describe the clinical features and evolution of PVL and to highlight the therapeutic benefits of diode laser ablation, which offers a minimally invasive, precise, and hemostatic treatment option that promotes rapid healing with minimal discomfort. This case underscores the value of early diagnosis, patient engagement, and long-term follow-up in managing PVL effectively.