Cerebral vasculitis is an uncommon but severe manifestation of systemic lupus erythematosus (SLE), often associated with complex management and unfavorable outcomes due to its neurological impact. We describe the case of a 32-year-old male with SLE who developed recurrent seizures and progressive cognitive decline. Clinical evaluation, laboratory investigations, and neuroimaging supported the diagnosis of lupus-related cerebral vasculitis. Despite aggressive immunosuppressive therapy, the patient experienced worsening neurological impairment, culminating in multiorgan failure and death. This report underscores the critical need for early recognition and prompt, intensive management of cerebral vasculitis in patients with SLE to improve prognosis.
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Ajertil, A. , Jirari, R. , Louis-Jaurè, M’Benga, S. K. and Quessar, A. E. (2025). Severe and Rare Cerebrovascular Involvement in Systemic Lupus Erythematosus: Case Report and Literature Review. Open Access Library Journal, 12, e14321. doi: http://dx.doi.org/10.4236/oalib.1114321.
Bertsias, G.K., Ioannidis, J.P.A., Aringer, M., Bollen, E., Bombardieri, S., Bruce, I.N., et al. (2010) EULAR Recommendations for the Management of Systemic Lupus Erythematosus with Neuropsychiatric Manifestations: Report of a Task Force of the EULAR Standing Committee for Clinical Affairs. Annals of the Rheumatic Diseases, 69, 2074-2082. https://doi.org/10.1136/ard.2010.130476
Hanly, J.G., Urowitz, M.B., Sanchez‐Guerrero, J., Bae, S.C., Gordon, C., Wallace, D.J., et al. (2007) Neuro-psychiatric Events at the Time of Diagnosis of Systemic Lupus Erythematosus: An International Inception Cohort Study. Arthritis & Rheumatism, 56, 265-273. https://doi.org/10.1002/art.22305
Zhang, X., Dong, Y., Tang, F., et al. (1999) Central Nervous System Involvement in Systemic Lupus Erythematosus. Chinese Journal of Internal Medicine, 38, 681-684.
Govoni, M., Bortoluzzi, A., Padovan, M., Silvagni, E., Borrelli, M., Donelli, F., et al. (2016) The Diagnosis and Clinical Management of the Neuropsychiatric Manifestations of Lupus. Journal of Autoimmunity, 74, 41-72. https://doi.org/10.1016/j.jaut.2016.06.013
Thirunavukkarasu, B., Gupta, K., Nada, R., Rathi, M., Dhir, V., Ahuja, C.K., et al. (2021) Neuropatho-logical Spectrum in Systemic Lupus Erythematosus: A Single Institute Autopsy Experience. Journal of Neuroimmunology, 353, Article ID: 577518. https://doi.org/10.1016/j.jneuroim.2021.577518
Emerson, J.S., Grue-newald, S.M., Gomes, L., Lin, M. and Swaminathan, S. (2023) The Conundrum of Neuropsychiatric Systemic Lupus Erythematosus: Current and Novel Ap-proaches to Diagnosis. Frontiers in Neurology, 14, Article 1111769. https://doi.org/10.3389/fneur.2023.1111769
Hanly, J.G., Urowitz, M., Gordon, C., et al. (2023) Neuropsychiatric Events in Systemic Lupus Erythematosus: Long-Term Outcomes from an International Inception Cohort Study. Arthritis & Rheumatology, 75, 802-813.
Fanouriakis, A., Kostopoulou, M., Alunno, A., et al. (2019) 2019 Update of the EULAR Recommendations for the Man-agement of Systemic Lupus Erythematosus. Annals of the Rheumatic Diseases, 78, 736-745.
Lassere, M.N., Johnson, K.R., Boers, M., et al. (2007) Defi-nitions and Validation Criteria for Biomarkers and Surrogate Endpoints: Devel-opment and Testing of a Quantitative Hierarchical Levels of Evidence Schema. The Journal of Rheumatology, 34, 607-615.
