This is a retrospective study, carried out in the General Medicine Department of the Siguiri Prefectural Hospital, between January 2022 and December 2023, based on the department’s hospitalization records. Out of a total of 400 diabetic patients, 35 patients were selected as having diabetic nephropathy (ND). The data was analyzed with the Epi Info software. The prevalence of diabetic nephropathy (ND) was 8.75%. The mean age of patients with ND was 48 ± 10 years. The sex ratio for men to women was 2:1. The male sex was the most represented (62.86% of cases). Glycaemic imbalance (HbA1c >8.0%) was observed in 70.5% (25) of patients with ND. Nephropathy in diabetic subjects was the cause of 44.9% (16) of all CKDs, it is the first cause of CKD in our study. Glycemic imbalance, hypertension, and metabolic syndrome were the main risk factors and progression of CKD reported in our hospital practice.
Cite this paper
Camara, T. , Camara, M. , Traore, A. , Konan, M. , Sylla, D. , Kake, A. , Diabate, L. and Cisse, M. (2025). Diabetic Nephropathy: A Study of 35 Cases at the Prefectural Hospital of Siguiri, Guinea: Epidemiological and Clinical Aspects. Open Access Library Journal, 12, e13301. doi: http://dx.doi.org/10.4236/oalib.1113301.
Held, P.J., Port, F.K., Blagg, C.R. and Agodoa, L.Y. (1990) The United States Renal Data System’s 1990 Annual Data Report: an introduction. American Journal of Kidney Diseases, 16, i-ii, 1-106.
Tuttle, K.R., Bakris, G.L., Bilous, R.W., Chiang, J.L., de Boer, I.H., Goldstein-Fuchs, J., et al. (2014) Diabetic Kidney Disease: A Report from an ADA Consensus Conference. American Journal of Kidney Diseases, 64, 510-533. https://doi.org/10.1053/j.ajkd.2014.08.001
Davies, M.J., D’Alessio, D.A., Fradkin, J., Kernan, W.N., Mathieu, C., Mingrone, G., et al. (2018) Management of Hyperglycemia in Type 2 Diabetes, 2018. a Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care, 41, 2669-2701. https://doi.org/10.2337/dci18-0033
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., et al. (2018) 2018 ESC/ESH Guidelines for the Management of Ar-terial Hypertension. European Heart Journal, 39, 3021-3104. https://doi.org/10.1093/eurheartj/ehy339
Catapano, A.L., Graham, I., De Backer, G., Wiklund, O., Chapman, M.J., Drexel, H., et al. (2016) 2016 ESC/EAS Guidelines for the Man-agement of Dyslipidaemias. European Heart Journal, 37, 2999-3058. https://doi.org/10.1093/eurheartj/ehw272
Zhu, Y., Pandya, B.J. and Choi, H.K. (2011) Prevalence of Gout and Hyperuricemia in the US General Population: The National Health and Nutrition Examination Survey 2007-2008: Preva-lence of Gout and Hyperuricemia in the US. Arthritis & Rheumatism, 63, 3136-3141. https://doi.org/10.1002/art.30520
Domenica Cappellini, M. and Motta, I. (2015) Anemia in Clinical Prac-tice—Definition and Classification: Does Hemoglobin Change with Aging? Seminars in Hematology, 52, 261-269. https://doi.org/10.1053/j.seminhematol.2015.07.006
Altemtam, N., Russell, J. and El Nahas, M. (2011) A Study of the Natural History of Diabetic Kidney Disease (DKD). Nephrology Dialysis Transplantation, 27, 1847-1854. https://doi.org/10.1093/ndt/gfr561
Rossing, K., Christensen, P.K., Hovind, P., Tarnow, L., Rossing, P. and Parving, H. (2004) Progression of Nephropathy in Type 2 Diabetic Patients. Kidney International, 66, 1596-1605. https://doi.org/10.1111/j.1523-1755.2004.00925.x
Bouenizabila, E., Loumingou, R., Motoula, M., Andzouana, N. and Monabeka, H. (2015) La néphropathie diabétique au CHU de Brazzaville, Congo: Aspects épidémiologiques, cliniques, et facteurs de risque. Médecine des Maladies Métaboliques, 9, 220-226. https://doi.org/10.1016/s1957-2557(15)30048-1
Lipscombe, L.L. and Hux, J.E. (2007) Trends in Diabetes Preva-lence, Incidence, and Mortality in Ontario, Canada 1995-2005: A Population-Based Study. The Lancet, 369, 750-756. https://doi.org/10.1016/s0140-6736(07)60361-4
Yokoyama, H., Tomonaga, O., Hirayama, M., Ishii, A., Takeda, M., Babazono, T., et al. (1997) Predictors of the Progression of Diabetic Nephropathy and the Beneficial Effect of Angioten-sin-Converting Enzyme Inhibitors in NIDDM Patients. Diabetologia, 40, 405-411. https://doi.org/10.1007/s001250050694
Keane, W.F., Brenner, B.M., de Zeeuw, D., Grunfeld, J., McGill, J., Mitch, W.E., et al. (2003) The Risk of Developing End-Stage Renal Disease in Patients with Type 2 Diabetes and Nephropathy: The RENAAL Study. Kidney International, 63, 1499-1507. https://doi.org/10.1046/j.1523-1755.2003.00885.x
Gerstein, H.C., Miller, M.E., Byington, R.P., et al. (2008) Effects of Intensive Glucose Lowering in Type 2 Diabetes. The New England Journal of Medicine, 358, 2545-2559.
Lin, C.H., Yang, W.C., Tsai, S.T., Tung, T.H. and Chou, P. (2007) A Communi-ty-Based Study of Chronic Kidney Disease among Type 2 Diabetics in Kinmen, Taiwan Region. Diabetes Research and Clinical Practice, 75, 306-312. https://doi.org/10.1016/j.diabres.2006.06.028
Bash, L.D., Selvin, E., Steffes, M., Coresh, J. and Astor, B.C. (2008) Poor Glycemic Control in Diabetes and the Risk of Incident Chronic Kidney Disease Even in the Absence of Albuminuria and Retinopathy: Atherosclerosis Risk in Communities (ARIC) Study. Archives of Internal Medicine, 168, 2440-2447. https://doi.org/10.1001/archinte.168.22.2440
Bouattar, T., Ahid, S., Benasila, S., Mattous, M., Rhou, H., Ouzeddoun, N., et al. (2009) Les facteurs de progression de la néphropathie diabétique: Prise en charge et évolution. Néphrologie & Thérapeutique, 5, 181-187. https://doi.org/10.1016/j.nephro.2008.12.004
Yokoyama, H., Kanno, S., Takahashi, S., Yamada, D., Honjo, J., Saito, K., et al. (2011) Risks for Glomerular Filtration Rate Decline in Association with Progression of Albuminuria in Type 2 Diabetes. Nephrology Dialysis Transplantation, 26, 2924-2930. https://doi.org/10.1093/ndt/gfq774
Zoppini, G., Targher, G., Chonchol, M., Ortalda, V., Negri, C., Stoico, V., et al. (2012) Predictors of Estimated GFR Decline in Patients with Type 2 Dia-betes and Preserved Kidney Function. Clinical Journal of the American Society of Nephrology, 7, 401-408. https://doi.org/10.2215/cjn.07650711