Syntheses, Characterization and Biological Effect Studies of Some New Heterocyclic Compounds Containing Pyrazole and Pyridazine Rings and Their Schiff Bases
A series of pyrazole and pyridazine derivatives and their Schiff bases were synthesized and tested for their antibacterial and antioxidant activities. The prepared compounds were analyzed using infrared, 1H NMR, and mass spec-trometry. Studies of the antibacterial and antioxidant compounds showed promising antibacterial and antioxidant activities.
Cite this paper
Obeid, A. O. , Al-Aghbari, S. A. , Al-Taifi, E. A. , Alhamzi, E. H. L. and Rageh, Z. (2025). Syntheses, Characterization and Biological Effect Studies of Some New Heterocyclic Compounds Containing Pyrazole and Pyridazine Rings and Their Schiff Bases. Open Access Library Journal, 12, e2623. doi: http://dx.doi.org/10.4236/oalib.1112623.
Karrouchi, K., Radi, S., Ramli, Y., Mabkhot, J.Y.N., Al-Aizari, F.A. and Ansar, M. (2018) Synthesis and Antioxidant Activities of Schiff Bases and Their Complexes: An Updated Review. Molecules, 23, 134.
Chakroborty, S., Bhanja, C. and Jena, S. (2013) A Fascinating Decade for the Synthesis of 1,2-Azoles. Heterocyclic Communications, 19, 79-87. https://doi.org/10.1515/hc-2013-0017
Alfonso‐Herrera, L.A., Rosete‐Luna, S., Hernández‐Romero, D., Rivera‐Villanueva, J.M., Olivares‐Romero, J.L., Cruz‐Navarro, J.A., et al. (2022) Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity. ChemMedChem, 17, 1-42. https://doi.org/10.1002/cmdc.202200367
Nossier, E., Fahmy, H., Khalifa, N., El-Eraky, W. and Baset, M. (2017) Design and Synthesis of Novel Pyrazole-Substituted Different Nitrogenous Heterocyclic Ring Systems as Potential Anti-Inflammatory Agents. Molecules, 22, Article No. 512. https://doi.org/10.3390/molecules22040512
El-Sayed, E.H. and Mohamed, K.S. (2019) Synthesis and Anti-Inflammatory Evaluation of Some New Pyrazole, Pyrimidine, Pyrazolo[1,5-a]Pyrimidine, Imidazo[1,2-b]Pyrazole and Pyrazolo[5,1-b]Quinazoline Derivatives Containing Indane Moiety. Polycyclic Aromatic Compounds, 41, 1077-1093. https://doi.org/10.1080/10406638.2019.1653941
Khan, M.F., Alam, M.M., Verma, G., Akhtar, W., Akhter, M. and Shaquiquzzaman, M. (2016) The Therapeutic Voyage of Pyrazole and Its Analogs: A Review. European Journal of Medicinal Chemistry, 120, 170-201. https://doi.org/10.1016/j.ejmech.2016.04.077
Flefel, E., Tantawy, W., El-Sofany, W., El-Shahat, M., El-Sayed, A. and Abd-Elshafy, D. (2017) Synthesis of Some New Pyridazine Derivatives for Anti-HAV Evaluation. Molecules, 22, Article No. 148. https://doi.org/10.3390/molecules22010148
Meanwell, N.A. (2023) The Pyridazine Heterocycle in Molecular Recognition and Drug Discovery. Medicinal Chemistry Research, 32, 1853-1921. https://doi.org/10.1007/s00044-023-03035-9
Fonkui, T.Y., Ikhile, M.I., Ndinteh, D.T. and Njobeh, P.B. (2019) Microbial Activity of Some Heterocyclic Schiff Bases and Metal Complexes: A Review. Tropical Journal of Pharmaceutical Research, 17, 2507-2518. https://doi.org/10.4314/tjpr.v17i12.29
Al Zoubi, W., Al‐Hamdani, A.A.S., Ahmed, S.D. and Ko, Y.G. (2017) Synthesis, Characterization, and Biological Activity of Schiff Bases Metal Complexes. Journal of Physical Organic Chemistry, 31, e3752. https://doi.org/10.1002/poc.3752
Shah,S.,S. Shah, D. Khan, I. Ahmad, S. U. and Rahman,A.(2020) Synthesis and Antioxidant Activities of Schiff Bases and Their Complexes: An Updated Review. Platinum Open Access Journal, 6, 6936-6963.
Karatas, H., Aydin, M., Turkmenoglu, B., Akkoc, S., Sahin, O. and Kokbudak, Z. (2022) In Silico and In Vitro Antiproliferative Activity Assessment of New Schiff Base. ChemistrySelect, 7, e202103679.
Kumar, K.S., Ganguly, S., Veerasamy, R. and De Clercq, E. (2010) Synthesis, Antiviral Activity and Cytotoxicity Evaluation of Schiff Bases of Some 2-Phenyl Quinazoline-4(3)h-ones. European Journal of Medicinal Chemistry, 45, 5474-5479. https://doi.org/10.1016/j.ejmech.2010.07.058
Ali, M., Sholkamy, E.N., Alobaidi, A.S., Al-Muhanna, M.K. and Barakat, A. (2023) Synthesis of Schiff Bases Based on Chitosan and Heterocyclic Moiety: Evaluation of Antimicrobial Activity. ACS Omega, 8, 47304-47312. https://doi.org/10.1021/acsomega.3c08446
Pontiki, E., Hadjipavlou-Litina, D. and Chaviara, A.T. (2008) Evaluation of Anti-Inflammatory and Antioxidant Activities of Copper(II) Schiff Mono-Base and Copper(II) Schiff Base Coordination Compounds of Dien with Heterocyclic Aldehydes and 2-amino-5-methyl-thiazole. Journal of Enzyme Inhibition and Medicinal Chemistry, 23, 1011-1017. https://doi.org/10.1080/14756360701841251
Amer, S., El-Wakiel, N. and El-Ghamry, H. (2013) Synthesis, Spectral, Antitumor and Antimicrobial Studies on Cu(II) Complexes of Purine and Triazole Schiff Base Derivatives. Journal of Molecular Structure, 1049, 326-335. https://doi.org/10.1016/j.molstruc.2013.06.059
Aljahdali, M.S. and El-Sherif, A.A. (2020) Synthesis and Biological Evaluation of Novel Zn(II) and Cd(II) Schiff Base Complexes as Antimicrobial, Antifungal, and Antioxidant Agents. Bioinorganic Chemistry and Applications, 2020, Article ID: 8866382. https://doi.org/10.1155/2020/8866382
Mesbah, M., Douadi, T., Sahli, F., Issaadi, S., Boukazoula, S. and Chafaa, S. (2018) Synthesis, Characterization, Spectroscopic Studies and Antimicrobial Activity of Three New Schiff Bases Derived from Heterocyclic Moiety. Journal of Molecular Structure, 1151, 41-48. https://doi.org/10.1016/j.molstruc.2017.08.098
da Silva, C.M., da Silva, D.L., Modolo, L.V., Alves, R.B., de Resende, M.A., Martins, C.V.B., et al. (2011) Schiff Bases: A Short Review of Their Antimicrobial Activities. Journal of Advanced Research, 2, 1-8. https://doi.org/10.1016/j.jare.2010.05.004
Sinha, A., Banerjee, K., Banerjee, A., Das, S. and Choudhuri, S.K. (2014) Synthesis, Characterization and Biological Evaluation of a Novel Vanadium Complex as a Possible Anticancer Agent. Journal of Organometallic Chemistry, 772, 34-41. https://doi.org/10.1016/j.jorganchem.2014.08.032
Hasan, A., Thomas, N.F. and Gapil, S. (2011) Synthesis, Characterization and Antifungal Evaluation of 5-Substituted-4-amino-1,2,4-triazole-3-thioesters. Molecules, 16, 1297-1309. https://doi.org/10.3390/molecules16021297
Bondock, S., El-Tarhoni, A.E. and Fadda, A.A. (2006) Comparative Studies of Some Novel Cu(II) Polymeric Complexes Derived from Cyanoacetylhydrazine (CAH; L). The Role of Solvents Used on the Structure and Geometry of the Isolated Cu2 Complexes. Arkivoc, 9, 113-156.
Alhamzi, H.L. and Maqtari, M.A. (2021) Effect of Some Volatile Oils on Staphylococcus aureus and Pseudomonas aeruginosa Isolates from Burn Patients. PSM Microbiology, 6, 95-107.
