Atorvastatin calcium (ATC) is a widely prescribed synthetic cholesterol-lowering agent classified as BCS class II. This study aimed to investigate the solubility of ATC in a methanol-water mixture, which was illustrated through a ternary phase diagram. Additionally, the influence of varying concentrations of Tween 20 on the solubility of ATC in this aqueous methanol mixture was examined. ATC exhibits maximum solubility in pure methanol, and the incorporation of surfactants significantly modifies the drug’s solubility profile depending on its concentration.
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