Cell therapy is a promising strategy for the treatment of endometrial hypotrophy, but the origin of these cells and injection site influence the therapeutic effect of cell therapy. This preliminary study aimed to investigate the efficacy of autologous adipose mesenchymal stem cells (ASCs) transplantation in regenerating endometrium in patients with endometrial hypotrophy. This cell therapy may become a promising treatment for infertile women with endometrial hypotrophy. A descriptive prospective study including 05 patients with endometrial hypotrophy was carried out at Mohammed VI University Hospital Center in Marrakesh over a period of two years (September 2020- September 2022). The patients between 18 and 45 with an infertility with endometrial hypotrophy < 7 mm, due to intra uterine adhesions (IUA), were included in this study. Autologous ADMSCs were isolated from patient’s adipose tissue obtained by liposuction and then transplanted into uterus by transcervical instillation using an embryo transfer catheter followed by estrogen hormone therapy.
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