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Kidney Disease and HIV Infection: Epidemiological and Clinical Aspects in N’Zérékoré Regional Hospital (Guinea)

DOI: 10.4236/oalib.1110423, PP. 1-9

Subject Areas: Nephrology, HIV

Keywords: Kidney Disease, HIV, HIVAN

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Abstract

HIV infection can affect all organs and renal involvement is common. The prevalence of renal abnormalities has been estimated at approximately 30% of patients. Patients and Methods: This was a prospective cross-sectional descriptive study over a period of six (6) months from April 30, 2017 to October 30, 2017. Results: During our study, 147 HIV-infected patients were registered in the medical department of the Regional Hospital of N’Zérékoré, among which 62% or 42.18% met our criteria and presented kidney disease. The age group of 46 - 55 years was the most represented with a frequency of 48.39%. The average age was 40 ± 6.32 years with extremes of 18 and 62 years. Almost all of our patients had polymorphic clinical manifestations dominated by physical asthenia with 91.94%, followed by fever with 83.87%, headache with 80.65% and diarrhea with 80.65%. The most represented physical sign was the pallor of the tegument and conjunctive with 56.45%, the oedema of the lower limbs with 43.55%. The markers of renal damage in our patients were dominated by proteinuria with 69.35%. Of the 62 patients with kidney disease, 47% or 75.80% were placed in the context of organic kidney damage and the types of damage most represented during our study were glomerular damage with 43.55%, followed by tubule-interstitial damage 22.58%. Chronic renal failure was the most observed type of failure in our patients with 60% against 40% of cases of acute renal failure. Conclusion: Kidney disease is very common and varies during HIV infection. Screening for kidney disease in the HIV population is therefore fundamental because its early diagnosis should allow the identification of patients at high risk of progression of kidney disease but also of hospitalization and mortality.

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Bah, A. B. , Balde, M. S. , Diakite, F. , Barry, K. B. , Tolno, A. , Kaba, M. L. and Bah, A. O. (2023). Kidney Disease and HIV Infection: Epidemiological and Clinical Aspects in N’Zérékoré Regional Hospital (Guinea). Open Access Library Journal, 10, e423. doi: http://dx.doi.org/10.4236/oalib.1110423.

References

[1]  Szczech, L.A., Gange, S.J., van der Horst, C., et al. (2002) Predictors of Proteinuria and Renal Failure among Women with HIV Infection. Kidney International, 61, 195-202. https://doi.org/10.1046/j.1523-1755.2002.00094.x
[2]  Deti, E.K., Thiebaut, R., Bonnet, F., et al. (2010) Prevalence and Factors Associated with Renal Impairment in HIV-Infected Patients, ANRS C03 Aquitaine Cohort, France. HIV Medicine, 11, 308-317. https://doi.org/10.1111/j.1468-1293.2009.00780.x
[3]  Kalim, S., Szczech, L.A. and Wyatt, C.M. (2008) Acute Kidney Injury in HIV Infected Patients. Seminars in Nephrology, 28, 556-562. https://doi.org/10.1016/j.semnephrol.2008.08.008
[4]  Struik, G.M., Den Exter, R.A., Munthali, C., et al. (2011) The Prevalence of Renal Impairment among Adults with Early HIV Disease in Blantyre, Malawi. International Journal of STD & AIDS, 22, 457-462. https://doi.org/10.1258/ijsa.2011.010521
[5]  Ouattara, B., Kra, O., Yao, H., Kadjo, K. and Niamkey, E.K. (2011) Particularités de l’insuffisance rénale chronique chez des patients adultes noirs hospitalisés dans le service de médecine interne du CHU de Treichville. Néphrologie & Thérapeutique, 7, 531-534. https://doi.org/10.1016/j.nephro.2011.03.009
[6]  Kaba, M.L. and Touré, Y.I. (2016) Prévalence des insuffisances rénales aigue et chronique chez les patients infectés par le VIH à Conakry. Néphrologie & Thérapeutique, 12, 408-409. https://doi.org/10.1016/j.nephro.2016.07.134
[7]  Cisse, M., Fall, K., Abdoul Karim, D., Niang, A. and Diouf, B. (2015) Atteintes rénales au cours de l’infection à VIH à Dakar: à propos de 32 cas. Néphrologie & Thérapeutique, 11, 371. https://doi.org/10.1016/j.nephro.2015.07.333
[8]  Nyimi, M.L., Lepira, F.B., Sumaili, K.E., Ebengo, B.C., Nseka, M.N. and Longo-mbenza B. (2001) Insuffisance rénale aiguë associée à l'infection par le VIH à Kinshasa à propos de 24 observations. Louvain Medical, 120, 167-172.
[9]  Ekat, M.H., Courpotin, C., Diafouka, M., Akolbout, M., Mahambou-Nsonde, D., Nzounza, P. and Simon, B. (2013) Prévalence et facteurs associés à l'insuffisance rénale chez les patients nouvellement dépistés VIH-positifs à Brazzaville (République du Congo). Medecine et Santé Tropicales, 23, 176-180. https://doi.org/10.1684/mst.2013.0170
[10]  Emem, C.P. (2008) Renaldisease in HIV-Seropositive Patients in Nigeria: An Assessment of Prevalence, Clinical Features and Risk Factors. Nephrology Dialysis Transplantation, 23, 741-746. https://doi.org/10.1093/ndt/gfm836
[11]  Kalayjian, R.C., Lau, B., Mechekano, R.N., et al. (2012) Risk Factors for Chronic Kidney Disease in a Large Cohort of HIV-1 Infected Individuals Initiating Antiretroviral Therapy in Routine Care. AIDS, 26, 1907-1915. https://doi.org/10.1097/QAD.0b013e328357f5ed
[12]  Peralta, C., Scherzer, R., Grunfeld, C., et al. (2014) Urinary Biomarkers of Kidney Injury Are Associated with All-Cause Mortality in the Women’s Interagency HIV Study (WIHS). HIV Medicine, 15, 291-300. https://doi.org/10.1111/hiv.12113
[13]  Jotwani, V., Scherzer, R., Estrella, M.M., et al. (2016) HIV Infection, Tenofovir Disoproxil Fumarate, and Urine Alpha1-Microglobulin: A Cross-Sectional Analysis in the Multicenter AIDS Cohort Study. American Journal of Kidney Diseases, 68, 571-581. https://doi.org/10.1053/j.ajkd.2016.03.430
[14]  Hadigan, C., Edwards, E., Rosenberg, A., et al. (2013) Microalbuminuria in HIV Disease. American Journal of Nephrology, 37, 443-451. https://doi.org/10.1159/000350384
[15]  Ross, M.J. and Klotman, P.E. (2002) Recent Progress in HIV-Associated Nephropathy. Journal of the American Society of Nephrology, 13, 2997-3004. https://doi.org/10.1097/01.ASN.0000040750.40907.99
[16]  Rosenberg, A.Z., Naicker, S., Winkler, C.A. and Kopp, J.B. (2015) HIV-Associated Nephropathies: Epidemiology, Pathology, Mechanisms and Treatment. Nature Reviews Nephrology, 11, 150-160. https://doi.org/10.1038/nrneph.2015.9
[17]  Janakirama, H., Abraham, G., Matthew, M., et al. (2016) Correlation of CD4 Counts with Renal Disease in HIV Positive Patients. Saudi Journal of Kidney Diseases and Transplantation, 19, 603-607.
[18]  Nobakht, E., Cohen, S.D., Rosenberg, A.Z. and Kimmel, P.L. (2016) HIV-Associated Immune Complex Kidney Disease. Nature Reviews Nephrology, 12, 291-300. https://doi.org/10.1038/nrneph.2015.216
[19]  Kimmel, P.L., Phillips, T.M., Ferreira-Centeno, A., Farkas-Szallasi, T., Abraham, A.A. and Garrett, C.T. (1992) Idiotypic IgA Nephropathy in Patients with Human Immunodeficiency Virus Infection. The New England Journal of Medicine, 327, 702-706. https://doi.org/10.1056/NEJM199209033271006
[20]  Kimmel, P.L., Phillips, T.M., Ferreira-Centeno, A., Farkas-Szallasi, T., Abraham, A.A. and Garrett, C.T. (1993) HIV-Associated Immunemediated Renal Disease. Kidney International, 44, 1327-1340. https://doi.org/10.1038/ki.1993.386
[21]  Ando, M. and Yanagisawa, N. (2015) Epidemiology, Clinical Characteristics and Management of Chronic Kidney Disease in Human Immunodeficiency Virus-Infected Patients. World Journal of Nephrology, 4, 388-395. https://doi.org/10.5527/wjn.v4.i3.388

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