全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

Experience of Transfusion Exchanges at the Center for Mixed Medicine and SS Anemia; Kinshasa, Democratic Republic of the Congo

DOI: 10.4236/oalib.1110015, PP. 1-12

Subject Areas: Hematology

Keywords: Sickle Cell Anemia, Transfusion Exchange, Indications, Reactions, Kinshasa

Full-Text   Cite this paper   Add to My Lib

Abstract

Context: Sickle cell anemia is a genetic and hereditary disease due to the presence of hemoglobin S. The Transfusion exchanges are carried out for preventive purposes or/and curative of certain complications. Objective: the assigned objective is to list indications, observed reactions, initial and final hemoglobin rates as well as different blood groups from sickle cell patients homozygous SS who had benefited from transfusion exchanges. Patients and Methods: This documentary and descriptive studies were carried out from December the first 2012 to July 31/2020 at the Center for Medicine Mixed and Anemia SS in Kinshasa. The technique of transfusion exchanges was manual. The parameters used were age, sex, pre-exchange hemoglobin level, post-exchange hemoglobin level, blood group, indications, and immediate and late reactions observed. Results: Transfusion exchanges have been done on 128 sickle cell patients including 47 males and 81 females with a sex ratio of 0.58. The greatest indication was stroke with 49.2%. The age group 0 - 10 years represents 57.6% of strokes. Observed reactions were urticaria 11.7%, Fever 8.6%, Headaches 6.5%, Vomiting 3.1%, and 70.3% have shown no reactions. The initial average hemoglobin rate is 8.2 g%. The final average hemoglobin is 9.2 with an increase. The most represented blood group is O with 32.8%. Conclusion: The manual exchange transfusion is adjusted depending upon the medium condition and requires further improvement for better following of patients.

Cite this paper

Kodondi, S. D. , Kimboko, J. M. , Kabakele, D. M. M. , Bokolo, M. W. , Tongu, E. N. , Kangite, G. Y. , Longina, R. K. , Tshunza, M. N. , Nsingi, K. L. , Nyembo, G. K. , Tukebana, F. N. , Umba, C. N. and Kabengele, B. O. (2023). Experience of Transfusion Exchanges at the Center for Mixed Medicine and SS Anemia; Kinshasa, Democratic Republic of the Congo. Open Access Library Journal, 10, e015. doi: http://dx.doi.org/10.4236/oalib.1110015.

References

[1]  Kaluila Mamba, J.F.J. and Manzombi, P.C. (2007) La drépanocytose, une identité, un combat et un métier. Bureau d’Etudes et de recherches pour la Promotion de la Santé, Kinshasa, 19.
[2]  Noizat-Pirenne, F. (2014) Drépanocytose et transfusion sanguine: La politique de l’établissement français du sang. Feuillets de Biologie, 55, 74-77.
[3]  Bachir, D. and Galacteros, F. (1994) Potential Alternative Treatments to Blood Transfusion in Hemoglobinopathies: Hydroxyurea (HU), Erythropoïetin (EPO), Butyratederived Products, Blood Substitutes. Transfusion Clinique et Biologique, 1, 35-39. https://doi.org/10.1016/S1246-7820(05)80055-2
[4]  Rouger, P., Le Pennec, P.Y. and Noizat-Pirenne, F. (2000) Le risque immunologique en transfusion et sa prévention. Transfusion Sanguine: Une approche sécuritaire. John Libbey Eurotext Limited, Montrouge, 244-261.
[5]  Kaluila Mamba, J.F.J., Kimboko Mpesi, J. and Panda Mulefu, J. (2012) La drépanocytose en pratique médicale courante en RD Congo. Bureau d’Etudes et de recherches pour la Promotion de la Santé, Kangu Mayumbe, 47-51.
[6]  Dokekias, A.E. and Basseila, G.B. (2010) Résultats des échanges transfusionnels partiels chez 42 patients drépanocytaires homozygotes au CHU de Brazzaville. Transfusion Clinique et Biologique, 17, 323-241. https://doi.org/10.1016/j.tracli.2010.06.027
[7]  Alson, A.O.R. (2017) échange transfusionnel partiel dans la drépanocytose. Transfusion Clinique et Biologique, 24, 372. https://doi.org/10.1016/j.tracli.2017.06.287
[8]  Ohene-Frempong, K., Weiner, S.J., Sleeper, L.A., Miller, S.T., Embury, S., Moohr, J.W., Wethers, D.L., Pegelow, C.H. and Gill, F.M. (1998) Cerebrovascular Accidents in Sickle Cell Disease: Rates and Risk Factors. Blood, 91, 288-294.
[9]  Van Baelen, H., Vandepitte, J. and Eeckels, R. (1969) Observations on Sickle Cell Aneamia and Haemoglobin Bart’s in Congolese Neonates. Annales de la Société Belge de Médecine Tropicale, 49, 157-165.
[10]  Kassogué, A., Coulibaly, M., Ouattara, Z., Diarra, A., Tembely, A., El Fassi, M.J., Farih, M.H. and Ouattara, K. (2014) Aspects cliniques et thérapeutiques du priapisme au CHU Gabriel Touré: Etude de 36 cas. Pan African Medical Journal, 17, Article 286. https://doi.org/10.11604/pamj.2014.17.286.4109
[11]  Bopp, T., Stephan, C., Samii, K. and Stirnemann, J. (2018) Syndrome thoracique aigu: Une complication grave de la drépanocytose. Revue Médicale Suisse, 14, 1844-1848. https://doi.org/10.53738/REVMED.2018.14.623.1844
[12]  Ndiaye, M., Niang, S.O., Diop, A., et al. (2016) Ulcères de jambe au cours de la drépanocytose: Etude retrospective de 40 cas. Annales de Dermatologie et de Vénéréologie, 143, 103-107. https://doi.org/10.1016/j.annder.2015.12.004
[13]  Ngolet, L.O., et al. (2017) Ulcère de jambe du sujet Drépanocytaire à Brazzaville. Health Science and Diseases, 18, 98-101.
[14]  Kevin, H.M., Richard, K.W., et al. (2015) A Comparison of Chronic Manual and Automated Red Blood Cell Exchange Transfusion in Sickle Cell Disease Patients. British Journal of Haematology, 170, 425-439. https://doi.org/10.1111/bjh.13294
[15]  Ngole, Z.M., Masidi Muwonga, J., Kabakele Maweja, D. and Bongo Munta, R. (2015) La transfusion sanguine chez l’enfant drépanocytaire avec AVC au centre de médecine mixte et d’anémie SS de Kinshasa. Médecine d’ Afrique Noire, 62, 207-214.
[16]  Maitre, B., Habibi, A., Roudot-Thoraval, F., Bachir, D., Belghiti, D.D., Galacteros, F., et al. (2000) Acute Chest Syndrome in Adults with Sickle Cell Disease. Therapeutic Approach, Outcome, and Results of BAL in a Monocentric Series of 107 Episodes. Chest, 117, 1386-1392. https://doi.org/10.1378/chest.117.5.1386
[17]  Sack, F.N., Chenegmi, B.C., Dorgho, E.N., Mba, L.E., Honba, A.H. and Mandengue, S.H. (2018) Influence du groupe sanguin sur la fréquence des crises vaso occlusives chez les drépanocytaires. Health Sciences and Disease, 19, 66-70.
[18]  Thornburg, C.D., Dixon, N., Burgett, S., Mortier, N.A., Schultz, W.H., Zimmerman, S.A., et al. (2009) A Pilot Study of Hydroxyurea to Prevent Chronic Organ Damage in Young Children with Sickle Cell Anemia. Pediatric Blood & Cancer, 52, 609-615. https://doi.org/10.1002/pbc.21738
[19]  Nkashama, G.M., Wakamb, G.K., Mulangu, A.M., Kupa, B.K. and Numbi, O.L. (2015) De l’hémoglobine SS à SF: Intérêt de l’hydroxyurée dans la prise en charge de la drépanocytose chez 2 enfants congolais et revue de la littérature. Pan African Medical Journal, 21, Article 124.

Full-Text


comments powered by Disqus

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133

WeChat 1538708413