Burkholderia pseudomallei is an unusual causative organism of infective endocarditis. We present a case of Melioidosis mitral valve endocarditis with dissemination to the liver and kidney in a young woman with underlying SLE with lupus nephritis. Despite the delay in reaching a diagnosis, the patient was successfully treated with intravenous Ceftazidime and oral trimethoprim-sulfamethoxazole and was discharged well. The identification of the specific aetiologic organism is important for timely diagnosis as well as treatment of infective endocarditis.
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