The Possibilities of Medical Cannabis Application in Dentistry in the Era of Cannabis Legislation in Morocco, One of the World’s Largest Producers of Cannabis
Objective: The aim of this review is to discuss the potential applications of Cannabis sativa L. and its secondary metabolites in dentistry, and the legal aspect of medical cannabis in Morocco, one of the world’s largest producers of cannabis. Methods: The data was searched through PubMed database, Scopus and Science Direct-Elsevier by several keywords in various combinations with a time period 2005-2022. Unavailable in full text, non-English, non-French data were excluded, as well as studies conducted on animals. Results: The articles were of various natures and were filtered after eliminating duplicates and reading the title, summary and full text. Of the 382 articles selected, 35 were deemed relevant. Conclusions: Although Cannabis sativa L. and its compounds have officially been approved for medical use in Morocco, more clinical investigations are needed to overcome the remaining challenges to the full adoption of medical cannabis in dentistry.
Cite this paper
Zeroual, R. and Danguir, A. (2023). The Possibilities of Medical Cannabis Application in Dentistry in the Era of Cannabis Legislation in Morocco, One of the World’s Largest Producers of Cannabis. Open Access Library Journal, 10, e9832. doi: http://dx.doi.org/10.4236/oalib.1109832.
Lowe, H., Toyang, N., Steele, B., Bryant, J., Ngwa, W. and Nedamat, K. (2021) The Current and Potential Application of Medicinal Cannabis Products in Dentistry. Dentistry Journal, 9, Article 106. https://doi.org/10.3390/dj9090106
Que, K., He, D., Jin, Y., Wu, L., Wang, F., Zhao, Z., et al. (2017) Expression of Cannabinoid Type 1 Receptors in Human Odontoblast Cells. Journal of Endodontics, 43, 283-288. https://doi.org/10.1016/j.joen.2016.10.004
Kozono, S., Matsuyama, T., Biwasa, K.K., Kawahara, K.I., Nakajima, Y., Yoshimoto, T., et al. (2010) Involvement of the Endocannabinoid System in Periodontal Healing. Biochemical and Biophysical Research Communications, 394, 928-933.
https://doi.org/10.1016/j.bbrc.2010.03.080
Radwan, M.M., Chandra, S., Gul, S. and ElSohly, M.A. (2021) Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis. Molecules, 26, Article 2774.
https://doi.org/10.3390/molecules26092774
Crocq, M.A. (2020) History of Cannabis and the Endocannabinoid System. Dialogues in Clinical Neuroscience, 22, 223-238.
https://doi.org/10.31887/DCNS.2020.22.3/mcrocq
Pisanti, S. and Bifulco, M. (2017) Modern History of Medical Cannabis: From Widespread Use to Prohibitionism and Back. Trends in Pharmacological Sciences, 38, 195-198. https://doi.org/10.1016/j.tips.2016.12.002
Schwertschlag, C. (2022) Qu’est-ce que le système endocannabinoïde et comment fonctionne-t-il? Laboratorios Beemine.
https://thebeeminelab.com/fr/systeme-endocannabinoide
Grossman, S., Tan, H. and Gadiwalla, Y. (2022) Cannabis and Orofacial Pain: A Systematic Review. British Journal of Oral and Maxillofacial Surgery, 60, e677-e690.
https://doi.org/10.1016/j.bjoms.2021.06.005
Nitecka-Buchta, A., Nowak-Wachol, A., Wachol, K., Walczyńska-Dragon, K., Olczyk, P., Batoryna, O., et al. (2019) Myorelaxant Effect of Transdermal Cannabidiol Application in Patients with TMD: A Randomized, Double-Blind Trial. Journal of Clinical Medicine, 8, Article 1886. https://doi.org/10.3390/jcm8111886
Ataei, A., Rahim Rezaee, S.A., Moeintaghavi, A., Ghanbari, H. and Azizi, M. (2022) Evaluation of Cannabinoid Receptors Type 1-2 in Periodontitis Patients. Clinical and Experimental Dental Research, 8, 1040-1044. https://doi.org/10.1002/cre2.608
Stahl, V. and Vasudevan, K. (2020) Comparison of Efficacy of Cannabinoids versus Commercial Oral Care Products in Reducing Bacterial Content from Dental Plaque: A Preliminary Observation. Cureus, 12, e6809. https://doi.org/10.7759/cureus.6809
Beneng, K., Renton, T., Yilmaz, Z., Yiangou, Y. and Anand, P. (2010) Cannabinoid Receptor CB1-Immunoreactive Nerve Fibres in Painful and Non-Painful Human Tooth Pulp. Journal of Clinical Neuroscience, 17, 1476-1479.
https://doi.org/10.1016/j.jocn.2010.04.005
Aqawi, M., Sionov, R.V., Gallily, R., Friedman, M. and Steinberg, D. (2021) Anti-Bacterial Properties of Cannabigerol toward Streptococcus mutans. Frontiers in Microbiology, 12, Article 656471. https://doi.org/10.3389/fmicb.2021.656471
Pan, W. and Zhang, G. (2019) Linalool Monoterpene Exerts Potent Antitumor Effects in OECM 1 Human Oral Cancer Cells by Inducing Sub-G1 Cell Cycle Arrest, Loss of Mitochondrial Membrane Potential and Inhibition of PI3K/AKT Biochemical Pathway. Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology, 24, 323-328.
Sachs, J., McGlade, E. and Yurgelun-Todd, D. (2015) Safety and Toxicology of Cannabinoids. Neurotherapeutics, 12, 735-746.
https://doi.org/10.1007/s13311-015-0380-8
Ransing, R., de la Rosa, P.A., Pereira-Sanchez, V., Handuleh, J.I.M., Jerotic, S., Gupta, A.K., et al. (2022) Current State of Cannabis Use, Policies, and Research across Sixteen Countries: Cross-Country Comparisons and International Perspectives. Trends in Psychiatry and Psychotherapy, 44, e20210263.
https://doi.org/10.47626/2237-6089-2021-0263
Elhamdaoui, O., Meiouet, M., Ajlal, A., Chergui, A. and Zakariya, I. (2019) Medicinal Cannabis and Challenges of Legislation in Morocco. International Journal of Pharmacognosy, 6, 323-328.
Haddou, N.B. (2021) Publication au BORM n° 7006 de la loi n° 13-21 relative aux usages licites du cannabis.
https://www.lexisma.info/2021/08/06/publication-au-borm-n-7006-de-la-loi-n-13-21-relative-aux-usages-licites-du-cannabis/
Tingman, S. (2019) Local Perceptions of Cannabis and Cannabis Laws in Morocco: Unpacking Past Laws, Moroccans’ Perceptions, and Exploring Organizational Efforts. Independent Study Project (ISP) Collection.
https://digitalcollections.sit.edu/isp_collection/3080
