Assessing the Effect and Use of an Aqueous Form of a Common Ghanaian Leaves Extract, Chromolaena odorata (Acheampong Leaf) on Coagulation Test Parameters in Vitro
Background: In Ghana, the use of Chromolaena odorata (Acheampong Leaf) as a first aid material to control bleeding is a very common practice in the rural areas. This study sought to assess the coagulation effect of aqueous extract of C. odorata (Acheampong Leaf) leaves on the coagulation profile. Methods: In this experimental study, freshly obtained C. odorata leaves extract was made using distilled water. Blood samples were taken from 197 non-hemophiliacs. PT and aPTT tests were tested with the extract. Results: The study result showed significantly reduced PT results of the study participants (17.89 ± 3.06 s to 16.43 ± 2.51 s, p < 0.0001) but no effect was recorded with aPTT (38.83 ± 7.13 s against 39.12 ± 7.85, p = 0.709). Conclusion: C. odorata proved to be strongly effective in promoting coagulation (procoagulant) in vitro. We recommend studies to isolate and purify the active chemical compound in C. odorata leaves to further the pathway and mechanism of action.
Cite this paper
Ofosu, D. N. , Asamoah, A. , Tuekpe, R. M. , Addo, E. O. , Takyi, E. K. and Addai, A. (2023). Assessing the Effect and Use of an Aqueous Form of a Common Ghanaian Leaves Extract, Chromolaena odorata (Acheampong Leaf) on Coagulation Test Parameters in Vitro. Open Access Library Journal, 10, e9611. doi: http://dx.doi.org/10.4236/oalib.1109611.
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