Autophagy is an important biological mechanism to transport proteins in organelles to lysosome for degradation, maintaining a stable physiological balance of the body. Acute Myeloid Leukemia (AML) refers to hematological malignancy caused by a disorder of myeloid hematopoietic stem cells. Recent studies have shown that the expression of some autophagy-related genes in AML patients is closely related to the prognosis and leukocyte formation of AML patients. Therefore, we can use autophagy as a potential target for monitoring, prognosis, and molecular diagnosis of leukemia patients. The study summarized the interaction between AML and autophagy-related signal pathways (such as mTOR and PI3K pathway) and explained the influence of related inhibitors and activators on AML cells in recent years, which laid a theoretical foundation for clinical treatment and research development of AML patients.
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Zhou, S. , Wu, Y. , Cai, Y. , Yu, Z. , Li, R. , Yan, C. , Dai, F. and Han, W. (2022). The Role of Autophagy in Acute Myeloid Leukemia
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