Efficacy of Bevacizumab versus Epidermal Growth Factor Receptor Inhibitors for Ras Wild Type Metastatic Colorectal Cancer: A Real-World Data Analysis from a Tertiary Care Institution
Introduction: A combination of chemotherapy regimen and biologics in patients with RAS wild-type (wt) metastatic colorectal cancer (mCRC) resulted in improvements in survival. However, the optimal choice of initial biologic therapy in previously untreated patients remains challenging. Aim: The objective of this study is to compare the efficacy and safety outcomes of first-line epidermal growth factor receptor (EGFR) inhibitors versus vascular endothelial growth factor (VEGF) inhibitors in patients with RAS wtmCRC. Methods: A retrospective analytical study of patients with RAS wtmCRC who received first-line chemotherapy with either bevacizumab or panitumumab/cetuximab was conducted at the department of medical oncology of Hassan II University Hospital of Fez, Morocco, over a period of 4 years (June 2015 to June 2019). Endpoints included overall survival (OS), progression-free survival (PFS) and overall response rate (ORR). Results: 85 patients were included: 48.2% (n = 41) received cetuximab or panitumumab and 51.7% (n = 44) received bevacizumab, in association with first-line chemotherapy. Median OS and PFS did not differ significantly between patients having received bevacizumab and cetuximab or panitumumab treatment. ORR was significantly higher with first-line treatment with EGFRi. The proportion of patients with treatment-related grade 3 or higher, adverse events was similar between treatment groups. Conclusion: Our study showed no significant difference in survival between the addition of cetuximab/panitumumab vs bevacizumab to first-line chemotherapy as initial biologic treatment in RAS-wt mCRC patients.
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Amaadour, L. , Berrad, S. , Harch, I. E. , Oualla, K. , Arifi, S. , Ghazi, K. E. , Chbani, L. , Benbrahim, Z. and Mellas, N. (2023). Efficacy of Bevacizumab versus Epidermal Growth Factor Receptor Inhibitors for Ras Wild Type Metastatic Colorectal Cancer: A Real-World Data Analysis from a Tertiary Care Institution. Open Access Library Journal, 10, e9293. doi: http://dx.doi.org/10.4236/oalib.1109293.
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