Background: Sickle cell disease is an autosomal recessive genetic disease characterized by a point mutation. In the Democratic Republic of Congo, approximately 40,000 newborns are born with sickle cell disease. Objective: The objective of the study is to determine the predominant reasons for consultation of sickle cell patients at the Center of Mixed Medicine and SS Anemia (CMMASS) in Kinshasa. Methods: This study was conducted at CMMASS. It is a retrospective study carried out on the files of elderly sickle cell patients who came for consultation in the period from January 1, 2018 to December 31, 2020. Any well-kept file of sickle cell patients over the age of 18 with a documented electrophoresis result having consulted during the study period was considered for work. The parameters of interest in this work were the different reasons for consultation. Results: 2463 SS homozygous sickle cell patients had been seen in consultation at the CMMASS. 1350 patients (54.8%) were women; thus giving a sex ratio of 1.21 in favor of women. The most represented age group is that of 18 to 25 years with 1148 patients (46.6%). The most common reasons for consultation in the series were osteoarticular pain (61.75%), fever (24.48%), pallor (12.59%), headache (7.8%), and cough (2.56%). Conclusion: Bone and joint pain was the most dominant reason for consultation among homozygous sickle cell patients at the CMMASS during the period from January 1, 2018 to December 31, 2020.
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Mulowayi, P. , Bongenya, B. , Bulanda, B. , Kateba, E. , Kodondi, S. , Vangu, C. , Nkolomoni, B. and Kamangu, E. N. (2022). Reasons for Consultation of Sickle Cell Patients at the Center for Mixed Medicine and SS Anemia. Open Access Library Journal, 9, e9132. doi: http://dx.doi.org/10.4236/oalib.1109132.
Mwanaut, I.M., Bongenya, B.I., Chuga, D., Kabasele, J.Y.D., Kateba, E.T., Okonda, M.O., Mukoka, S.K., Tshibumbu, C.K., Bulanda, B.I. and Kamangu, E.N. (2019) Seroprevalence of HIV, HBV Infections and HIV/HBV Coinfection in Polytransfused Adult Sickle-Cell Disease: Case of Center of Mixed Medicine and SS Anemia of Kinshasa. ARC Journal of AIDS, 4, 18-21.
Piel, F.B., Steinerg, M.H. and Rees, D.C. (2017) Sickle Cell Disease. The New England Journal of Medicine, 376, 561-573.
https://doi.org/10.1056/NEJMra1510865
Piel, F.B., Hay, S.L., Gupta, S.D., Weatherall, D.J. and Williams, T.N. (2013) Global Burden of Sickle Cell Anemia in Children under Five, 2010-2050: Modeling Based on Demographics, Excess Mortality, and Interventions. PLOS Medicine, 10, e1001484.
https://doi.org/10.1371/journal.pmed.1001484
Agasa, B., Bosunga, K., Opara, A., Tshilumbu, K., Dupont, E., Vertogen, F., Vertongen, F., Cotton, F. and Gulbis, B. (2010) Prevalence of Sickle Cell Disease in Northeastern Region of the Democratic Republic of Congo: What Impact on Transfusion Policy? Transfusion Medicine, 20, 62-65.
https://doi.org/10.1111/j.1365-3148.2009.00943.x
Tshlolo, L., Aissi, L.M., Lukusa, D., Kinshiama, C., Wembonyama, S., Gulbis, B. and Vertongen, F. (2009) Néonatal Screening for Sickle Cell Anemia in the Democratic Republic of Congo; Experience from a Pioneer Project on 31204 Newborns. Journal of Clinical Pathology, 62, 35-38. https://doi.org/10.1136/jcp.2008.058958
Thiam, L., Dramé, A., Zokébé, I.C., Niokhor, F.D., Seck, N., Boiro, D., Abdoulaye, A.N., Basse, I., Niang, B., Deme, I.L., Sylla, A., Diagne, I. and Ndiaye, O. (2017) Profils épidémiologiques, cliniques et hématologiques de la drépanocytose homozygote SS en phase inter critique chez l’enfant à Ziguinchor, Sénégal. Pan African Medical Journal, 28, Article 208. https://www.doi.org/10.11604/pamj.2017.28.208.14006
https://doi.org/10.11604/pamj.2017.28.208.14006
Samira, O. (2015) Drépanocytose homozygote chez l’enfant à l’hôpital provincial de Tanger: A propos de 10 cas. Thèse Méd Rabat, Université Mohammed V de Rabat, Rabat.
Nacoulma, E.W.C., Sakande, J., Kafando, E., Kpowbié, E.D. and Guissou, I.P. (2006) Profil hématologique et biochimique des drépanocytaires SS et SC en phase stationnaire au Centre Hospitalier National Yalgado Ouedraogo de Ouagadougou. Mali Medical, 21, 8-11.
Thuilliez, V. and Vierin, Y. (1997) Le poids de la drépanocytose en milieu pédiatrique au Gabon. Santé Publique, 3, 45-60. https://doi.org/10.1016/0929-693X(96)87087-4
Dreux, O. (2012) Education thérapeutique pour les enfants drépanocytaires: Justifications à la mise en place et initiation de ce projet au CHU de Grenoble. Thèse Méd, Université Joseph Fournier, Grenoble.
Nacoulma, E.W.C., Bonkoungou, P., Dembelele, Ye, D. and Kam, L. (2006) Les drépanocytoses majeures dans le service de pédiatrie du centre hospitalier universitaire Sourou Sanon de Bobo Dioulasso. Medecine d’Afrique Noire, 53, 694-698.
Kouakou, B., N’dhatz, E., Nanho, D.C., Sangare, A., Sanogo, I. and Tolo, A. (2006) Profil évolutif de la drépanocytose homozygote suivie: Expérience du service d’hématologie clinique du CHU de Yopougon. Medecine d’Afrique Noire, 53, 5-10.
Chetcha Chemegni, B., Ngouefo, G., Ngo Sack, F., Ngouadjeu, E., Kouemeni, L. and Kaptué Noche, L. (2017) Complications aigues de la drépanocytose aigues. Journal Marocain des Sciences Médicales, 21, 18-23.
Diop, S., Mokono, S.O., Ndiaye, M., Touré Fall, A.O., Thiam, D. and Diakhaté, L. (2003) La Drépanocytose homozygote après l’age de 20 ans: Suivi d’une cohorte de 108 patients au CHU de Dakar. La Revue de Médecine Interne, 24, 711-715.
https://doi.org/10.1016/S0248-8663(03)00220-0
Platt, O.S., Brambilla, D.J., Rosse, W.F., Milner, P.F., Castro, O., Steinberg, M.H. and Klug, P.P. (1994) Mortality in Sickle Cell Disease: Life Expectancy and Risk Factors for Early Death. The New England Journal of Medicine, 330, 1639-1644.
https://doi.org/10.1056/NEJM199406093302303
