All Title Author
Keywords Abstract

Publish in OALib Journal
ISSN: 2333-9721
APC: Only $99


Recurrent Cyst within Willebrand Disease: Place of Surgery?

DOI: 10.4236/oalib.1108731, PP. 1-8

Subject Areas: Gynecology & Obstetrics, Hematology

Keywords: Willebrand Disease, Recurrent Ovarian Cyst, Medical Treatment

Full-Text   Cite this paper   Add to My Lib


Von Willebrand factor is a multimeric glycoprotein that plays an essential role in platelet-rich thrombi formation under high shear stress. The heterogeneity of Von Willebrand disease (vWD) illustrates the complex physiology of this protein. For women, menstrual patterns and heavy menstrual bleeding are the most frequent disorders within the inherited bleeding disorders population. Pelvic pain due to recurrent hemorrhagic ovarian cyst does not appear to have a higher frequency in the vWD population. Though, it can be a source of impaired quality of life and many invasive procedures. In this report, we will describe the management of a recurrent ovarian cyst and show the importance of medical/conservative treatment without loaning to surgery.

Cite this paper

Nafidi, M. , Khald, A. , Aboulfalah, A. and Soummani, A. (2022). Recurrent Cyst within Willebrand Disease: Place of Surgery?. Open Access Library Journal, 9, e8731. doi:


[1]  Zimmerman, T.S. (1982) Von Willebrand’s Disease. Progress in Hemostasis and Thrombosis, 6, 203.
[2]  Rodeghiero, F., Castaman, G. and Dini, E. (1987) Epidemiological Investigation of the Prevalence of von Willebrand’s Disease. Blood, 69, 454-459.
[3]  Calmette, L. and Clauser, S. (2018) Von Willebrand Disease. La Revue de Médecine Interne, 39, 918-924.
[4]  Werner, E.J., Broxson, E.H., Tucker, E.L., Giroux, D.S., Shults, J. and Abshire, T.C. (1993) Prevalence of von Willebrand Disease in Children: A Multiethnic Study. The Journal of Pediatrics, 123, 893-898.
[5]  Casari, C., Lenting, P.J., Wohner, N., Christophe, O.D. and Denis, C.V. (2013) Clearance of von Willebrand Factor. Journal of Thrombosis and Haemostasis, 11, 202-211.
[6]  Bowen, D.J. and Collins, P.W. (2004) An Amino Acid Polymorphism in von Willebrand Factor Correlates with Increased Susceptibility to Proteolysis by ADAMTS13. Blood, 103, 941-947.
[7]  Castaman, G., Goodeve, A. and Eikenboom, J. (2013) Principles of Care for the Diagnosis and Treatment of von Willebrand Disease. Haematologica, 98, 667-674.
[8]  Kadir, R.A., Economides, D.L., Sabin, C.A., Owens, D. and Lee, C.A. (1999) Variations in Coagulation Factors in Women: Effects of Age, Ethnicity, Menstrual Cycle and Combined Oral Contraceptive. Thrombosis and Haemostasis, 82, 1456-1461.
[9]  Miller, C.H., Dilley, A.B., Drews, C., Richardson, L. and Evatt, B. (2002) Changes in von Willebrand Factor and Factor VIII Levels during the Menstrual Cycle. Thrombosis and Haemostasis, 87, 1082-1083.
[10]  Sie, P., Caron, C., Azam, J., Goudemand, J., Grandjean, H., Boneu, B., et al. (2003) Reassessment of von Willebrand Factor (VWF), VWF Propeptide, Factor VIII: C and Plasminogen Activator Inhibitors 1 and 2 during Normal Pregnancy. British Journal of Haematology, 121, 897-903.
[11]  David, J.L., Gaspard, U.J., Gillain, D., Raskinet, R. and Lepot, M.R. (1990) Hemostasis Profile in Women Taking Low-Dose Oral Contraceptives. American Journal of Obstetrics & Gynecology, 163, 420-423.
[12]  Biggs, R. and Matthews, J.M. (1963) The Treatment of Haemorrhage in von Willebrand’s Disease and the Blood Level of Factor VIII (AHG). British Journal of Haematology, 9, 203-214.
[13]  Phillips, M.D. and Santhouse, A. (1998) von Willebrand Disease: Recent Advances in Pathophysiology and Treatment. The American Journal of the Medical Sciences, 316, 77-86.
[14]  Dkeidek, A., Mattinson, R. and Grover, S.R. (2021) Bleeding Disorders: Are Gynaecologists Testing Women at Risk? Haemophilia, 27, e534-e536.
[15]  Committee on Gynecologic Practice (2002) Von Willebrand’s Disease in Gynecologic Practice. International Journal of Gynecology & Obstetrics, 76, 336-337.
[16]  American College of Obstetricians and Gynecologists (2000) Management of Anovulatory Bleeding. ACOG Practice Bulletin, No. 14, ACOG, Washington DC.
[17]  Lasry, A., Gil, Y. and Balayla, J. (2020) Use of Tranexamic Acid for the Treatment of Mittelschmerz in a Patient with Type 1 von Willebrand Disease and Recurrent Hemorrhagic Cysts. Journal of Obstetrics and Gynaecology Canada, 42, 1385-1387.
[18]  Bottomley, C. and Bourne, T. (2009) Diagnosis and Management of Ovarian Cyst Accidents. Best Practice & Research Clinical Obstetrics & Gynaecology, 23, 711-724.


comments powered by Disqus

Contact Us