Animal experiments are a source of an on-going scientific and non-scientific discussion. Since time immemorial utility of animals for the service of manhood has been practiced. These experimental animal models have distinct advantages because of their ability to reproduce in vivo cellular details and responses occurring in humans. This review addresses various animal models in use for periodontology, oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC) research work.
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