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Teratogenic Investigation of Bay Leaf (Syzygium polyanthum Wight.) Ethanol Extract on Morphology of Fetal Mice (Mus musculus L.) Strain DDY

DOI: 10.4236/oalib.1108385, PP. 1-13

Subject Areas: Toxicology

Keywords: Fetus, Mice, Organogenesis, Resorption, S. polyanthum

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Abstract

This research was conducted to observe the teratogenic potential of S. polyanthum ethanol extract on morphology of fetal mice strain DDY. Thirty pregnant female mice were divided into 5 groups, normal group and treatment groups with dose 0.5; 5; 50; 500 mg/bw. The extract was given orally from 6th to 15th day of gestation. The results showed that the effect of S. polyanthum ethanol extract at a dose of 0.5 mg/bw did not cause resorption and external malformation. At a dose of 5 mg/bw, there were resorption (6.15%) and fetal open eyelids (1.63%). Resorption (7.69%; 9.34%) and fetal hemorrhage (1.63%; 1.47%) were found in mice given doses of 50 and 500 mg/bw. The treatment of S. polyanthum ethanol extract at doses 0.5; 5; 50; 500 mg/bw during the period of organogenesis did not have a significant influence on morphology of fetal mice strain DDY (p > 0.05).

Cite this paper

Angelina, M. , Ovy, A. , Dewijanti, I. D. , Mardhiyah, A. and Sjahfirdi, L. (2022). Teratogenic Investigation of Bay Leaf (Syzygium polyanthum Wight.) Ethanol Extract on Morphology of Fetal Mice (Mus musculus L.) Strain DDY. Open Access Library Journal, 9, e8385. doi: http://dx.doi.org/10.4236/oalib.1108385.

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