To investigate the effect of additives on the crystal morphology and crystal form. Acetaminophen crystals were prepared by cooling crystallization using ethanol as the solvent and adding different types of polymer compounds. The crystals of acetaminophen were characterized by X-ray powder diffraction, infrared spectroscopy, and optical microscopy. The results showed that polyethylene glycol was more effective in the inhibition of crystallization, which compared with tetrafluoroethylene, paraffin film and cellulose. In addition, although the increasement of polyethylene glycol content had no effect on the crystal form of acetaminophen, the crystal diameter diminished. This study provides reference for the stable production of crystal form I of acetaminophen.
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