Introduction: Von Willebrand disease (VWD) is the commonest inherited bleeding disorder worldwide. The prevalence of VWD in African or Nigerian population is however not known. Objective: To determine the prevalence of VWD among apparently healthy youths in Ibadan, Southwestern Nigeria. Materials and Method: This was a descriptive, analytical, cross-sectional study, in which one hundred and eighty-two participants who met the inclusion criteria and who consented to partake in the study were recruited. Blood samples were taken for some hematological parameters. VWF:ag levels and factor VIII levels were determined by ELISA method using SPAN VWF and SPAN Factor VIII ELISA kits respectively. Results: Participants were aged 15 to 35 years with mean age of 22.96 ± 4.22 years. Majority (75.8%) were in the age range 20 to 24 years. Ninety-six (52.7%) of them were males while 86 (47.3%) were females. The prevalence of VWD in this study was 2.2%. The levels of VWF: Ag correlated positively well with FVIII antigen level (r = 0.487, p = 0.0001). Conclusion: The prevalence of VWD is 2.2% among apparently healthy youths in Ibadan, Southwestern Nigeria. There was a strong statistical relationship between the VWF:Ag level and FVIII antigen level (p = 0.0001).
Cite this paper
Shonde-Adebola, K. B. , Shokunbi, W. A. and Adebola, M. B. (2021). Prevalence of von Willebrand Disease among Nigerian Youths in Ibadan, South-Western Nigeria. Open Access Library Journal, 8, e7789. doi: http://dx.doi.org/10.4236/oalib.1107789.
Borhany, M., et al. (2011) Clinical Features and Types of Von Willebrand Disease in Karachi. Clinical and Applied Thrombosis/Hemostasis, 17, E102-E105.
Federici, A.B. (2006) Diagnosis of Inherited von Willebrand Disease: A Clinical Perspective. Seminars in Thrombosis and Hemostasis, 32, 555-565.
https://doi.org/10.1055/s-2006-949661
Mohlke, K.L. and Ginsburg, D. (1997) Von Willebrand Disease and Quantitative Deficiency of Von Willebrand Factor. Journal of Laboratory and Clinical Medicine, 130, 252-261. https://doi.org/10.1016/S0022-2143(97)90019-6
Sadler, J.E., Budde, U. and Eienboom, J.C. (2006) Update on the Pathophysiology and Classification of Von Willebrand Disease: A Report of the Subcommittee on Von Willebrand Factor. Journal of Thrombosis and Haemostasis, 4, 2103-2114.
https://doi.org/10.1111/j.1538-7836.2006.02146.x
Ginsburg, D., et al. (1985) Human Von Willebrand Factor (vWF): Isolation of Complementary DNA (cDNA) Clones and Chromosomal Localization. Science, 228, 1401-1406. https://doi.org/10.1126/science.3874428
deWit, T.R. and vanMourik, J.A. (2001) Biosynthesis, Processing and Secretion of von Willebrand Factor: Biological Implications. Best Practice & Research Clinical Haematology, 14, 241-255. https://doi.org/10.1053/beha.2001.0132
Ruggeri, Z.M., Ware, J. and Ginsburg, D. (2003) Von Willebrand Factor. In: Loscalzo, J. and AI, S., Eds., Thrombosis and Haemorrhage, 3rd Edition, Philadelphia Lippincott, Williams & Wilkins, Philadelphia, 246.
Sadler, J.E. (1998) Biochemistry and Genetics of von Willebrand Factor. Annual Review of Biochemistry, 67, 395-424.
https://doi.org/10.1146/annurev.biochem.67.1.395
Gill, J.C., Endres-Brooks, J., Bauer, P.J., Marks, W.J. and Montgomery, R.R. (1987) The Effect of ABO Blood Group on the Diagnosis of von Willebrand Disease. Blood, 69, 1691-1695. https://doi.org/10.1182/blood.V69.6.1691.1691
Nitu-Whalley, I.C. and Lee, C.A. (2000) Type 1 von Willebrand Disease: A Clinical Retrospective Study of the Diagnosis, the Influence of ABO Blood Group and the Role of Bleeding History. British Journal of Haematology, 108, 259-264.
https://doi.org/10.1046/j.1365-2141.2000.01830.x
Van Loon, J.E., Kavousi, M., Felix, J.F., Leebeek, F.W., Hofman, A., Witterman, J.C., et al. (2012) Von Willebrand Factor Plasma Levels, Genetic Variations and Coronary Heart Dissease in Older Popoulation. Journal of Thrombosis and Haemostasis, 10, 1262-1269. https://doi.org/10.1111/j.1538-7836.2012.04771.x
Nosek-Cenkowska, B., Cheang, M.S. and Pizzi, N.J. (1991) Bleeding/Bruising Symptomatology in Children with and without Bleeding Disorders. Thromb Haemost, 65, 237-241. https://doi.org/10.1055/s-0038-1647491
Rodeghiero, F. and Castaman, G. and Dini, E. (1987) Epidemiological Investigation of the Prevalence of von Willebrand’s Disease. Blood, 69, 454-459.
https://doi.org/10.1182/blood.V69.2.454.454
Bloom, A.L. (1991) Von Willebrand Factor: Clinical Features of Inherited and Acquired Disorders. Mayo Clinic Proceedings, 66, 743.
https://doi.org/10.1016/S0025-6196(12)62088-6
Sandhu, M.K., Shah, S., Jacoby, S.H. and Cohen, A.J. (2012) Patterns of Bleeding in Males with von Willebrand Disease. Blood, 120, 1129.
https://doi.org/10.1182/blood.V120.21.1129.1129
Akpan, I.S. and Essien, E.M. (2016) ABO Blood Group Status and von Willebrand Factor Antigen Levels in a Cohort of 100 Blood Donors in an African Population. International Journal of Biomedical Research, 7, 219-222.
