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Incidences, Case Fatality Rates and Epidemiology of Melioidosis Worldwide: A Review Paper

DOI: 10.4236/oalib.1107537, PP. 1-20

Subject Areas: Epidemiology

Keywords: Melioidosis, Incidences, Case Fatality Rates, Epidemiology

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Abstract

Melioidosis is an uncommon, opportunistic disease caused by Burkholderia pseudomallei that lives freely in soil, water, and harsh environments. Transmission occurs from direct exposure of the bacteria to soil or contaminated water supplies. The case fatality rate (CFR) of Melioidosis is high and increases in children and underdeveloped countries. Unfortunately, the disease remains understudied around the world. We carried out an extensive literature review in a systematic approach. A detailed search strategy and PRISMA chart was used to select the relevant articles from reliable medical databases. Articles published from 2016 to 2020 that addressed the incidences, case fatality rates and epidemiology of Melioidosis are selected based on selection criteria. Finally, a total of 34 articles were included in this review. We identified 15,202 cases of Melioidosis globally from 1913-2018 with a total CFR of 33.9%. We calculated the global incidence of ~2607 per year and a CFR of ~814 (35.4%) per year. There are 80% (n = 2476) of adult cases and 20% (n = 620) of paediatric cases. The total (n = 12,413) male to female ratio of Melioidosis is 2.21:1. We also found that the male to female ratio of adult cases (n = 804) is 3.57:1, whereas that of paediatric cases (n = 318) is 1.39:1. The number of patients found working in the agricultural sector was 36.5% (n = 1068). We found a higher incidence and a lower total CFR which are consistent with previously reported studies. We also found that the percentage of paediatric cases was higher than in previous studies, and there is a considerable difference in male to female ratio between adult cases and paediatric cases. This review provides significant evidence to the public health policy makers to develop an effective preventable intervention to reduce the incidence and case fatality of this neglected tropical disease.

Cite this paper

Fong, J. H. , Pillai, N. , Yap, C. G. and Jahan, N. K. (2021). Incidences, Case Fatality Rates and Epidemiology of Melioidosis Worldwide: A Review Paper. Open Access Library Journal, 8, e7537. doi: http://dx.doi.org/10.4236/oalib.1107537.

References

[1]  Wiersinga, W.J., Currie, B.J. and Peacock, S.J. (2012) Melioidosis. New England Journal of Medicine, 367, 1035-1044. https://doi.org/10.1056/NEJMra1204699
[2]  Whitmore, A. (1913) An Account of a Glanders-Like Disease Occurring in Rangoon. Epidemiology & Infection, 13, 1-34. https://doi.org/10.1017/S0022172400005234
[3]  Perumal Samy, R., Stiles, B.G., Sethi, G. and Lim, L.H.K. (2017) Melioidosis: Clinical Impact and Public Health Threat in the Tropics. PLoS Neglected Tropical Diseases, 11, e0004738. https://doi.org/10.1371/journal.pntd.0004738
[4]  Molyneux, D.H., Savioli, L. and Engels, D. (2017) Neglected Tropical Diseases: Progress towards Addressing the Chronic Pandemic. The Lancet, 389, 312-325. https://doi.org/10.1016/S0140-6736(16)30171-4
[5]  Wiersinga, W.J., Virk, H.S., Torres, A.G., Currie, B.J., Peacock, S.J., Dance, D.A.B., et al. (2018) Melioidosis. Nature Reviews Disease Primers, 4, Article No. 17107. https://doi.org/10.1038/nrdp.2017.107
[6]  Depoorter, E., Bull, M.J., Peeters, C., Coenye, T., Vandamme, P., Mahenthiralingam, E. (2016) Burkholderia: An Update on Taxonomy and Biotechnological Potential as Antibiotic Producers. Applied Microbiology and Biotechnology, 100, 5215-5229. https://doi.org/10.1007/s00253-016-7520-x
[7]  Lipuma, J.J., Currie, B.J., Peacock, S.J. and Vandamme, P.A. (2015) Burkholderia, Stenotrophomonas, Ralstonia, Cupriavidus, Pandoraea, Brevundimonas, Comamonas, Delftia, and Acidovorax. In: Jorgensen, J.H., Carroll, K.C., Funke, G., Pfaller, M.A., Louise Landry, M., Richter, S.S. and Warnock, D.W., Eds., Manual of Clinical Microbiology, 11th Edition, American Society of Microbiology Press, Almere, 791-812. https://doi.org/10.1128/9781555817381.ch43
[8]  Kaestli, M., Schmid, M., Mayo, M., Rothballer, M., Harrington, G., Richardson, L., et al. (2012) Out of the Ground: Aerial and Exotic Habitats of the Melioidosis Bacterium Burkholderia pseudomallei in Grasses in Australia. Environmental Microbiology, 14, 2058-2070. https://doi.org/10.1111/j.1462-2920.2011.02671.x
[9]  Limmathurotsakul, D., Wongsuvan, G., Aanensen, D., Ngamwilai, S., Saiprom, N., Rongkard, P., et al. (2014) Melioidosis Caused by Burkholderia pseudomallei in Drinking Water, Thailand, 2012. Emerging Infectious Diseases, 20, 265-268. https://doi.org/10.3201/eid2002.121891
[10]  Chen, P.-S., Chen, Y.-S., Lin, H.-H., Liu, P.-J., Ni, W.-F., Hsueh, P.-T., et al. (2015) Airborne Transmission of Melioidosis to Humans from Environmental Aerosols Contaminated with B. pseudomallei. PLoS Neglected Tropical Diseases, 9, e0003834. https://doi.org/10.1371/journal.pntd.0003834
[11]  Merritt, A.J., Peck, M., Gayle, D., Levy, A., Ler, Y.-H., Raby, E., et al. (2016) Cutaneous Melioidosis Cluster Caused by Contaminated Wound Irrigation Fluid. Emerging Infectious Diseases, 22, 1420-1427. https://doi.org/10.3201/eid2208.151149
[12]  Pearson, T., Giffard, P., Beckstrom-Sternberg, S., Auerbach, R., Hornstra, H., Tuanyok, A., et al. (2009) Phylogeographic Reconstruction of a Bacterial Species with High Levels of Lateral Gene Transfer. BMC Biology, 7, Article No. 78. https://doi.org/10.1186/1741-7007-7-78
[13]  Currie, B.J. (2015) Melioidosis: Evolving Concepts in Epidemiology, Pathogenesis, and Treatment. Seminars in Respiratory and Critical Care Medicine, 36, 111-125. https://doi.org/10.1055/s-0034-1398389
[14]  Cheng, A.C. and Currie, B.J. (2005) Melioidosis: Epidemiology, Pathophysiology, and Management. Clinical Microbiology Reviews, 18, 383-416. https://doi.org/10.1128/CMR.18.2.383-416.2005
[15]  Chai, L.Y.A. and Fisher, D. (2018) Earth, Wind, Rain, and Melioidosis. The Lancet Planetary Health, 2, e329-e330. https://doi.org/10.1016/S2542-5196(18)30165-7
[16]  Liu, X., Pang, L., Sim, S.H., Goh, K.T., Ravikumar, S., Win, M.S., et al. (2015) Association of Melioidosis Incidence with Rainfall and Humidity, Singapore, 2003-2012. Emerging Infectious Diseases, 21, 159-162. https://doi.org/10.3201/eid2101.140042
[17]  Limmathurotsakul, D., Golding, N., Dance, D.A., Messina, J.P., Pigott, D.M., Moyes, C.L., et al. (2016) Predicted Global Distribution of Burkholderia pseudomallei and Burden of Melioidosis. Nature Microbiology, 1, Article No. 15008. https://doi.org/10.1038/nmicrobiol.2015.8
[18]  Fong, S.M., Wong, K.J., Fukushima, M. and Yeo, T.W. (2015) Thalassemia Major Is a Major Risk Factor for Pediatric Melioidosis in Kota Kinabalu, Sabah, Malaysia. Clinical Infectious Diseases, 60, 1802-1807. https://doi.org/10.1093/cid/civ189
[19]  Moreno, R.M., Jimenez Jr., V. and Monroy, F.P. (2019) Impact of Binge Alcohol Intoxication on the Humoral Immune Response during Burkholderia spp. Infections. Microorganisms, 7, Article No. 125. https://doi.org/10.3390/microorganisms7050125
[20]  Limmathurotsakul, D., Wongratanacheewin, S., Teerawattanasook, N., Wongsuvan, G., Chaisuksant, S., Chetchotisakd, P., et al. (2010) Increasing Incidence of Human Melioidosis in Northeast Thailand. The American Journal of Tropical Medicine and Hygiene, 82, 1113-1117. https://doi.org/10.4269/ajtmh.2010.10-0038
[21]  Currie, B.J., Jacups, S.P., Cheng, A.C., Fisher, D.A., Anstey, N.M., Huffam, S.E., et al. (2004) Melioidosis Epidemiology and Risk Factors from a Prospective Whole-Population Study in Northern Australia. Tropical Medicine & International Health, 9, 1167-1174. https://doi.org/10.1111/j.1365-3156.2004.01328.x
[22]  McLeod, C., Morris, P.S., Bauert, P.A., Kilburn, C.J., Ward, L.M., Baird, R.W., et al. (2015) Clinical Presentation and Medical Management of Melioidosis in Children: A 24-Year Prospective Study in the Northern Territory of Australia and Review of the Literature. Clinical Infectious Diseases, 60, 21-26. https://doi.org/10.1093/cid/ciu733
[23]  Turner, P., Kloprogge, S., Miliya, T., Soeng, S., Tan, P., Sar, P., et al. (2016) A Retrospective Analysis of Melioidosis in Cambodian Children, 2009-2013. BMC Infectious Diseases, 16, Article No. 688. https://doi.org/10.1186/s12879-016-2034-9
[24]  Lim, M., Tan, E., Soh, C. and Chang, T. (1997) Burkholderia pseudomallei Infection in the Singapore Armed Forces from 1987 to 1994—An Epidemiological Review. Annals of the Academy of Medicine, Singapore, 26, 13-17.
[25]  Hadano, Y. (2018) Imported Melioidosis in Japan: A Review of Cases. Infection and Drug Resistance, 11, 163-168. https://doi.org/10.2147/IDR.S154696
[26]  Le Tohic, S., Montana, M., Koch, L., Curti, C. and Vanelle, P. (2019) A Review of Melioidosis Cases Imported into Europe. European Journal of Clinical Microbiology & Infectious Diseases, 38, 1395-1408. https://doi.org/10.1007/s10096-019-03548-5
[27]  Hempenstall, A.J., Smith, S., Stanton, D. and Hanson, J. (2019) Melioidosis in the Torres Strait Islands, Australia: Exquisite Interplay between Pathogen, Host, and Environment. American Journal of Tropical Medicine & Hygiene, 100, 517-521. https://doi.org/10.4269/ajtmh.18-0806
[28]  Abu Hassan, M.R., Aziz, N., Ismail, N., Shafie, Z., Mayala, B., Donohue, R.E., et al. (2019) Socio-Epidemiological and Land Cover Risk Factors for Melioidosis in Kedah, Northern Malaysia. PLoS Neglected Tropical Diseases, 13, e0007243. https://doi.org/10.1371/journal.pntd.0007243
[29]  Araúz, A.B., Castillo, K., Santiago, E., Quintero, Y., Adames, E., Castillo, B., et al. (2020) Geographic Distribution and Incidence of Melioidosis, Panama. Emerging Infectious Diseases, 26, 118-121. https://doi.org/10.3201/eid2601.180870
[30]  Bulterys, P.L., Bulterys, M.A., Phommasone, K., Luangraj, M., Mayxay, M., Kloprogge, S., et al. (2018) Climatic Drivers of Melioidosis in Laos and Cambodia: A 16-Year Case Series Analysis. The Lancet Planetary Health, 2, e334-e343. https://doi.org/10.1016/S2542-5196(18)30172-4
[31]  Chowdhury, F.R., Shariful Alam Jilani, M., Barai, L., Rahman, T., Saha, M.R., Robed Amin, M., et al. (2018) Melioidosis in Bangladesh: A Clinical and Epidemiological Analysis of Culture-Confirmed Cases. Tropical Medicine and Infectious Disease, 3, Article No. 40. https://doi.org/10.3390/tropicalmed3020040
[32]  Corea, E.M., De Silva, A.D. and Thevanesam, V. (2018) Melioidosis in Sri Lanka. Tropical Medicine and Infectious Disease, 3, Article No. 22. https://doi.org/10.3390/tropicalmed3010022
[33]  Dance, D.A.B, Luangraj, M., Rattanavong, S., Sithivong, N., Vongnalaysane, O., Vongsouvath, M., et al. (2018) Melioidosis in the Lao People’s Democratic Republic. Tropical Medicine and Infectious Disease, 3, Article No. 21. https://doi.org/10.3390/tropicalmed3010021
[34]  Hantrakun, V., Kongyu, S., Klaytong, P., Rongsumlee, S., Day, N.P.J., Peacock, S.J., et al. (2019) Clinical Epidemiology of 7126 Melioidosis Patients in Thailand and the Implications for a National Notifiable Diseases Surveillance System. Open Forum Infectious Diseases, 6, Article No. ofz498. https://doi.org/10.1093/ofid/ofz498
[35]  Hsueh, P.T., Huang, W.T., Hsueh, H.K., Chen, Y.L. and Chen, Y.S. (2018) Transmission Modes of Melioidosis in Taiwan. Tropical Medicine and Infectious Disease, 3, Article No. 26. https://doi.org/10.3390/tropicalmed3010026
[36]  Jatapai, A., Gregory, C.J., Thamthitiwat, S., Tanwisaid, K., Bhengsri, S., Baggett, H.C., et al. (2018) Hospitalized Bacteremic Melioidosis in Rural Thailand: 2009-2013. American Journal of Tropical Medicine & Hygiene, 98, 1585-1591. https://doi.org/10.4269/ajtmh.17-0402
[37]  Lui, G., Tam, A., Tso, E.Y.K., Wu, A.K.L., Zee, J., Choi, K.W., et al. (2018) Melioidosis in Hong Kong. Tropical Medicine and Infectious Disease, 3, Article No. 91. https://doi.org/10.3390/tropicalmed3030091
[38]  Muthumbi, E.M., Gordon, N.C., Mochamah, G., Nyongesa, S., Odipo, E., Mwarumba, S., et al. (2019) Population-Based Estimate of Melioidosis, Kenya. Emerging Infectious Diseases, 25, 984-987. https://doi.org/10.3201/eid2505.180545
[39]  Nathan, S., Chieng, S., Kingsley, P.V., Mohan, A., Podin, Y., Ooi, M.H., et al. (2018) Melioidosis in Malaysia: Incidence, Clinical Challenges, and Advances in Understanding Pathogenesis. Tropical Medicine and Infectious Disease, 3, Article No. 25. https://doi.org/10.3390/tropicalmed3010025
[40]  Pande, K., Kadir, K.A.A., Asli, R. and Chong, V.H. (2018) Melioidosis in Brunei Darussalam. Tropical Medicine and Infectious Disease, 3, Article No. 20. https://doi.org/10.3390/tropicalmed3010020
[41]  Pang, L., Harris, P.N.A., Seiler, R.L., Ooi, P.L., Cutter, J., Goh, K.T., et al. (2018) Melioidosis, Singapore, 2003-2014. Emerging Infectious Diseases, 24, 140-143. https://doi.org/10.3201/eid2401.161449
[42]  Rolim, D.B., Lima, R.X.R., Ribeiro, A.K.C., Colares, R.M., Lima, L.D.Q., Rodríguez- Morales, A.J., et al. (2018) Melioidosis in South America. Tropical Medicine and Infectious Disease, 3, Article No. 60. https://doi.org/10.3390/tropicalmed3020060
[43]  San Martin, P.F.M., Chua, J.C., Bautista, R.L.P., Nailes, J.M., Panaligan, M.M. and Dance, D.A.B. (2018) Melioidosis in the Philippines. Tropical Medicine and Infectious Disease, 3, Article No. 99. https://doi.org/10.3390/tropicalmed3030099
[44]  Sanchez-Villamil, J.I. and Torres, A.G. (2018) Melioidosis in Mexico, Central America, and the Caribbean. Tropical Medicine and Infectious Disease, 3, Article No. 24. https://doi.org/10.3390/tropicalmed3010024
[45]  Smith, S., Stewart, J.D., Tacon, C., Archer, N. and Hanson, J. (2017) Children with Melioidosis in Far North Queensland Are Commonly Bacteraemic and Have a High Case Fatality Rate. Communicable Diseases Intelligence Quarterly Report, 41, E318-E321.
[46]  Stephens, D.P., Thomas, J.H., Ward, L.M. and Currie, B.J. (2016) Melioidosis Causing Critical Illness: A Review of 24 Years of Experience from the Royal Darwin Hospital ICU. Critical Care Medicine, 44, 1500-1505. https://doi.org/10.1097/CCM.0000000000001668
[47]  Stewart, J.D., Smith, S., Binotto, E., McBride, W.J., Currie, B.J. and Hanson J. (2017) The Epidemiology and Clinical Features of Melioidosis in Far North Queensland: Implications for Patient Management. PLoS Neglected Tropical Diseases, 11, e0005411. https://doi.org/10.1371/journal.pntd.0005411
[48]  Suttisunhakul, V., Hip, P., Ouch, P., Ly, P., Supaprom, C., Rachmat, A., et al. (2018) Retrospective Analysis of Fever and Sepsis Patients from Cambodia Reveals Serological Evidence of Melioidosis. American Journal of Tropical Medicine & Hygiene, 98, 1039-1045. https://doi.org/10.4269/ajtmh.17-0885
[49]  Tang, R.Y., Lim, S.H., Lam, J.E., Salim, N., Toh, S.S.E. and Chan, Y.W. (2019) A 5-Year Retrospective Study of Melioidosis Cases Treated in a District Specialist Hospital. Medical Journal of Malaysia, 74, 472-476.
[50]  Tang, Y., Deng, J., Zhang, J., Zhong, X., Qiu, Y., Zhang, H., et al. (2018) Epidemiological and Clinical Features of Melioidosis: A Report of Seven Cases from Southern Inland China. American Journal of Tropical Medicine & Hygiene, 98, 1296-1399. https://doi.org/10.4269/ajtmh.17-0128
[51]  Tauran, P.M., Wahyunie, S., Saad, F., Dahesihdewi, A., Graciella, M., Muhammad, M, et al. (2018) Emergence of Melioidosis in Indonesia and Today’s Challenges. Tropical Medicine and Infectious Disease, 3, Article No. 32. https://doi.org/10.3390/tropicalmed3010032
[52]  Tipre, M., Kingsley, P., Smith, T., Leader, M. and Sathiakumar N. (2018) Melioidosis in India and Bangladesh: A Review of Case Reports. Asian Pacific Journal of Tropical Medicine, 11, 320-329. https://doi.org/10.4103/1995-7645.233179
[53]  Trinh, T., Hoang, T., Tran, D., Trinh, V., Göhler, A., Nguyen, T., et al. (2018) A Simple Laboratory Algorithm for Diagnosis of Melioidosis in Resource-Constrained Areas: A study from North-Central Vietnam. Clinical Microbiology and Infection, 24, 84.e1-84.e4. https://doi.org/10.1016/j.cmi.2017.07.029
[54]  Win, M.M., Ashley, E.A., Zin, K.N., Aung, M.T., Swe, M.M.M., Ling, C.L., et al. (2018) Melioidosis in Myanmar. Tropical Medicine and Infectious Disease, 3, Article No. 28. https://doi.org/10.3390/tropicalmed3010028
[55]  Yazid, M.B., Fauzi, M.H., Hasan, H., Noh, A.Y. and Deris, Z.Z. (2017) An 11-Year Analysis of Emergency Presentations of Melioidosis in Northeastern Malaysia. Journal of Immigrant & Minority Health, 19, 774-777. https://doi.org/10.1007/s10903-016-0429-8
[56]  Zheng, X., Xia, Q., Xia, L. and Li, W. (2019) Endemic Melioidosis in Southern China: Past and Present. Tropical Medicine and Infectious Disease, 4, Article No. 39. https://doi.org/10.3390/tropicalmed4010039
[57]  Sim, S.H., Ong, C.E.L., Gan, Y.H., Wang, D., Koh, V.W.H., Tan, Y.K., et al. (2018) Melioidosis in Singapore: Clinical, Veterinary, and Environmental Perspectives. Tropical Medicine and Infectious Disease, 3, Article No. 31. https://doi.org/10.3390/tropicalmed3010031
[58]  Smith, S., Hanson, J. and Currie, B.J. (2018) Melioidosis: An Australian Perspective. Tropical Medicine and Infectious Disease, 3, Article No. 27. https://doi.org/10.3390/tropicalmed3010027
[59]  Koh, G.C., Maude, R.R., Schreiber, M.F., Limmathurotsakul, D., Wiersinga, W.J., Wuthiekanun, V., et al. (2011) Glyburide Is Anti-Inflammatory and Associated with Reduced Mortality in Melioidosis. Clinical Infectious Diseases, 52, 717-725. https://doi.org/10.1093/cid/ciq192
[60]  Currie, B.J., Ward, L. and Cheng, A.C. (2010) The Epidemiology and Clinical Spectrum of Melioidosis: 540 Cases from the 20 Year Darwin Prospective Study. PLoS Neglected Tropical Diseases, 4, e900. https://doi.org/10.1371/journal.pntd.0000900
[61]  Sanderson, C. and Currie, BJ. (2014) Melioidosis: A Pediatric Disease. The Pediatric Infectious Disease Journal, 33, 770-771. https://doi.org/10.1097/INF.0000000000000358
[62]  Cheng, A.C., Wuthiekanun, V., Limmathurotsakul, D., Chierakul, W. and Peacock, S.J. (2008) Intensity of Exposure and Incidence of Melioidosis in Thai Children. Transactions of the Royal Society of Tropical Medicine and Hygiene, 102, S37-S39. https://doi.org/10.1016/S0035-9203(08)70010-5
[63]  Dance, D., Davis, T., Wattanagoon, Y., Chaowagul, W., Saiphan, P., Looareesuwan, S., et al. (1989) Acute Suppurative Parotitis Caused by Pseudomonas pseudomallei in Children. Journal of Infectious Diseases, 159, 654-660. https://doi.org/10.1093/infdis/159.4.654
[64]  Limmathurotsakul, D. and Peacock, S.J. (2011) Melioidosis: A Clinical Overview. British Medical Bulletin, 99, 125-139. https://doi.org/10.1093/bmb/ldr007
[65]  Stoesser, N., Pocock, J., Moore, C.E., Soeng, S., Chhat, H.P., Sar, P., et al. (2012) Pediatric Suppurative Parotitis in Cambodia 2007-2011. The Pediatric Infectious Disease Journal, 31, 865-868. https://doi.org/10.1097/INF.0b013e318258873b
[66]  Lumbiganon, P. and Viengnondha, S. (1995) Clinical Manifestations of Melioidosis in Children. The Pediatric Infectious Disease Journal, 14, 136-139. https://doi.org/10.1097/00006454-199502000-00010
[67]  Mukhopadhyay, C., Eshwara, V.K., Kini, P. and Bhat, V. (2015) Pediatric Melioidosis in Southern India. Indian Pediatrics, 52, 711-712.
[68]  Birnie, E., Virk, H.S., Savelkoel, J., Spijker, R., Bertherat, E., Dance, D.A.B., et al. (2019) Global Burden of Melioidosis in 2015: A Systematic Review and Data Synthesis. Lancet Infectious Diseases, 19, 892-902. https://doi.org/10.1016/S1473-3099(19)30157-4
[69]  Limmathurotsakul, D., Kanoksil, M., Wuthiekanun, V., Kitphati, R., de Stavola, B., Day, N.P., et al. (2013) Activities of Daily Living Associated with Acquisition of Melioidosis in Northeast Thailand: A Matched Case-Control Study. PLoS Neglected Tropical Diseases, 7, e2072. https://doi.org/10.1371/journal.pntd.0002072
[70]  Birnie, E, Savelkoel, J., Reubsaet, F., Roelofs, J.J.T.H., Soetekouw, R., Kolkman, S., et al. (2019) Melioidosis in Travelers: An Analysis of Dutch Melioidosis Registry Data 1985-2018. Travel Medicine and Infectious Disease, 32, Article ID: 101461. https://doi.org/10.1016/j.tmaid.2019.07.017

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