All Title Author
Keywords Abstract

Publish in OALib Journal
ISSN: 2333-9721
APC: Only $99


Biochemical Effect of Nigella sativa (Black Cumin) on Glucose and Lipid Profile among Sudanese Diabetic Patients

DOI: 10.4236/oalib.1107500, PP. 1-8

Subject Areas: Diabetes & Endocrinology

Keywords: Diabetes, Glucose, Herbal Medicine, Lipid Profile

Full-Text   Cite this paper   Add to My Lib


Background: Diabetes mellitus (DM) is a common chronic disease; it is associated with alterations of blood glucose and lipid profile. Current evidence indicated beneficial effects of some medicinal herbs on metabolic parameters. Aim: The aim of this study was to investigate the effect of Nigella Sativa (NS) supplementation on blood glucose and lipid profile levels among type 2 DM Sudanese patients. Materials and Methods: the experimental study was conducted at Gezira state-Khartoum during the period from November 2019 to February 2020. Forty-five diabetic patients were randomly selected. Study population was classified into three groups; each contained 15 patients; glucose and lipid profile were estimated in all participants three times, the first one in day 0, the second after 15 days of daily intake of NS and the last sample after 30 days. Group 1 was given NS at concentration of 1 gram, and group 2 was given NS at concentration of 2 grams, while group 3 was given at concentration of 3 grams. Results: The included patients in the groups used NS with different dose, showed significant (P < 0.05) improvement with reference to blood glucose, while there was no significant improvement of lipid profile in all groups. Conclusion: Using regular NS can improve blood glucose level but has no effect on serum lipids. Concentration of two grams of NS has a better effect on blood glucose control.

Cite this paper

Allah, H. A. K. , Modawe, G. A. and Abdrabo, A. E. A. (2021). Biochemical Effect of Nigella sativa (Black Cumin) on Glucose and Lipid Profile among Sudanese Diabetic Patients. Open Access Library Journal, 8, e7500. doi:


[1]  Carvalho, C., Santos, R.X., Cardoso, S., Correia, S., Oliveira, P.J., Santos, M.S., et al. (2009) Doxorubicin: The Good, the Bad and the Ugly Effect. Current Medicinal Chemistry, 16, 3267-3285.
[2]  Mazzone, T. (2010) Intensive Glucose Lowering and Cardiovascular Disease Prevention in Diabetes: Reconciling the Recent Clinical Trial Data. Circulation, 122, 2201-2211.
[3]  Stratton, I.M., Adler, A.I., Neil, H.A.W., Matthews, D.R., Manley, S.E., Cull, C.A., et al. (2000) Association of Glycaemia with Macrovascular and Microvascular Complications of Type 2 Diabetes (UKPDS 35): Prospective Observational Study. BMJ, 321, 405-412.
[4]  Andersen, T., Schmidt, J., Thomassen, M., Hornstrup, T., Frandsen, U., Randers, M.B., et al. (2014) A Preliminary Study: Effects of Football Training on Glucose Control, Body Composition, and Performance in Men with Type 2 Diabetes. Scandinavian Journal of Medicine & Science in Sports, 24, 43-56.
[5]  Tahraoui, A., El-Hilaly, J., Israili, Z. and Lyoussi, B. (2007) Ethnopharmacological Survey of Plants Used in the Traditional Treatment of Hypertension and Diabetes in South-Eastern Morocco (Errachidia Province). Journal of Ethnopharmacology, 110, 105-117.
[6]  Alimohammadi, S., et al. (2013) Protective and Antidiabetic Effects of Extract from Nigella sativa on Blood Glucose Concentrations against Streptozotocin (STZ)-Induced Diabetic in Rats: An Experimental Study with Histopathological Evaluation. Diagnostic Pathology, 8, 137.
[7]  Fararh, K., Atoji, Y., Shimizu, Y., Shiina, T., Nikami, H. and Takewaki, T. (2004) Mechanisms of the Hypoglycaemic and Immunopotentiating Effects of Nigella sativa L. Oil in Streptozotocin-Induced Diabetic Hamsters. Research in Veterinary Science, 77, 123-129.
[8]  Benhaddou-Andaloussi, A., Martineau, L.C., Spoor, D., Vuong, T., Leduc, C., Joly, E., et al. (2008) Antidiabetic Activity of Nigella sativa. Seed Extract in Cultured Pancreatic β-Cells, Skeletal Muscle Cells, and Adipocytes. Pharmaceutical Biology, 46, 96-104.
[9]  Benhaddou-Andaloussi, A., Martineau, L., Vuong, T., Meddah, B., Madiraju, P., Settaf, A., et al. (2011) The in Vivo Antidiabetic Activity of Nigella sativa Is Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content. Evidence-Based Complementary and Alternative Medicine, 2011, Article ID: 538671.
[10]  Badary, O.A., Taha, R.A., Gamal El-Din, A.M. and Abdel-Wahab, M.H. (2003) Thymoquinone Is a Potent Superoxide Anion Scavenger. Drug and Chemical Toxicology, 26, 87-98.
[11]  Kanter, M., Coskun, O., Korkmaz, A. and Oter, S. (2004) Effects of Nigella sativa on Oxidative Stress and β-Cell Damage in Streptozotocin-Induced Diabetic Rats. The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology: An Official Publication of the American Association of Anatomists, 279, 685-691.
[12]  Al Wafai, R.J. (2013) Nigella sativa and Thymoquinone Suppress Cyclooxygenase-2 and Oxidative Stress in Pancreatic Tissue of Streptozotocin-Induced Diabetic Rats. Pancreas, 42, 841-849.
[13]  Najmi, A., Nasiruddin, M., Khan, R.A. and Haque, S.F. (2008) Effect of Nigella sativa Oil on Various Clinical and Biochemical Parameters of Insulin Resistance Syndrome. International Journal of Diabetes in Developing Countries, 28, 11.
[14]  Bamosa, A.O., Kaatabi, H., Lebdaa, F.M., Elq, A. and Al-Sultanb, A. (2010) Effect of Nigella sativa Seeds on the Glycemic Control of Patients with Type 2 Diabetes Mellitus. Indian Journal of Physiology and Pharmacology, 54, 344-354.
[15]  Tremblay, A.J., Morrissette, H., Gagné, J.-M., Bergeron, J., Gagné, C. and Couture, P. (2004) Validation of the Friedewald Formula for the Determination of Low-Density Lipoprotein Cholesterol Compared with β-Quantification in a Large Population. Clinical Biochemistry, 37, 785-790.
[16]  Shah, A.S., Khan, G.M., Badshah, A., Shah, S.U., Shah, K.U., Mirza, S.A., et al. (2012) Nigella sativa Provides Protection against Metabolic Syndrome. African Journal of Biotechnology, 11, 10919-10925.
[17]  Datau, E., Surachmanto, E.E., Pandelaki, K. and Langi, J. (2010) Efficacy of Nigella sativa on Serum Free Testosterone and Metabolic Disturbances in Central Obese Male. Acta Medica Indonesiana, 42, 130-134.
[18]  Meral, I., Yener, Z., Kahraman, T. and Mert, N. (2001) Effect of Nigella sativa on Glucose Concentration, Lipid Peroxidation, Anti-Oxidant Defence System and Liver Damage in Experimentally-Induced Diabetic Rabbits. Journal of Veterinary Medicine Series A, 48, 593-599.
[19]  Ibrahim, R.M., Hamdan, N.S., Ismail, M., Saini, S.M., Abd Rashid, S.N., AbdLatiff, L., et al. (2014) Protective Effects of Nigella sativa on Metabolic Syndrome in Menopausal Women. Advanced Pharmaceutical Bulletin, 4, 29.
[20]  Hosseini, M., Mirkarimi, S., Amini, M., Mohtashami, R., Kianbakht, S. and Fallah, H.H. (2013) Effects of Nigella sativa L. Seed Oil in Type II Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Journal of Medicinal Plants, 12, 93-99.
[21]  Dehkordi, F.R. and Kamkhah, A.F. (2008) Antihypertensive Effect of Nigella sativa Seed Extract in Patients with Mild Hypertension. Fundamental & Clinical Pharmacology, 22, 447-452.
[22]  Qidwai, W., et al. (2009) Effectiveness, Safety, and Tolerability of Powdered Nigella sativa (kalonji) Seed in Capsules on Serum Lipid Levels, Blood Sugar, Blood Pressure, and Body Weight in Adults: Results of a Randomized, Double-Blind Controlled Trial. The Journal of Alternative and Complementary Medicine, 15, 639-644.
[23]  Badar, A., et al. (2017) Effect of Nigella sativa Supplementation over a One-Year Period on Lipid Levels, Blood Pressure and Heart Rate in Type-2 Diabetic Patients Receiving Oral Hypoglycemic Agents: Nonrandomized Clinical Trial. Annals of Saudi Medicine, 37, 56-63.
[24]  Mohtashami, A., et al. (2016) Effects of Bread with Nigella sativa on Lipid Profiles, Apolipoproteins and Inflammatory Factor in Metabolic Syndrome Patients. Clinical Nutrition Research, 5, 89-95.
[25]  Kaatabi, H., et al. (2015) Nigella sativa Improves Glycemic Control and Ameliorates Oxidative Stress in Patients with Type 2 Diabetes Mellitus: Placebo Controlled Participant Blinded Clinical Trial. PLoS ONE, 10, e0113486.


comments powered by Disqus

Contact Us


WhatsApp +8615387084133

WeChat 1538708413