The Application Value of Interleukin-10 and Interleukin-15 in Osteoporosis

Objective: To investigate the effects of cytokines IL-10 and IL-15 in osteoporosis, and to provide a basis for the prevention and treatment of osteoporosis. Methods: A total of 101 subjects who underwent bone density testing in Linyi People’s Hospital from January 2018-December 2019 were selected and divided into normal bone density group, osteopenia group and osteoporosis group according to their bone density. At the same time, the peripheral serum IL-10 and IL-15 levels of subjects were detected. Results: The serum IL-10 and IL-15 levels of subjects with normal bone density were significantly higher than those of subjects with bone loss (t = 5.31, P < 0.001) (t = 6.87, P < 0.001) and osteoporosis. In the subjects (t = 5.38, P < 0.001) (t = 5.30, P < 0.001), the bone mineral density of the lumbar spine L1-L4 was positively correlated with serum IL-15 levels (r = 0.216, P = 0.030), but with IL-10 No correlation (r = ？0.025, P = 0.801). Femoral neck bone mineral density was positively correlated with serum IL-10 levels (r = 0.209, P = 0.036), and femoral neck bone mineral density was positively correlated with serum IL-15 levels (r = 0.405, P < 0.001). Stepwise regression analysis shows that IL-15 is closely related to bone density. Conclusion: Serum IL-10 and IL-15 have a protective effect on bone mass. Two anti-inflammatory cytokines play an important role in the occurrence and development of osteoporosis. Low levels of serum IL-10 and IL-15 have a protective effect on bone mass. Bone loss and osteoporosis have certain evaluation value, which can be used to prevent the occurrence of osteoporosis, reduce the risk of fracture, and reduce the difficulty and burden of nursing.