Syphilis in a pregnant woman keeps threatening the life of both the woman and her fetus at any time of pregnancy. While the control of this disease seemed to be effective around the 2000s in developed countries, its prevalence in pregnant women has risen all over the world especially in countries with limited resources. Although syphilis control in pregnant women would be part of the health policy of almost all the countries of sub-Saharan Africa, this opportunity is unfortunately not capitalized to the maximum by pregnant women who, for the most part, do attend health facilities only during the last trimesters of pregnancy. The purpose of this case study is to evaluate effective methods in screening pregnant women for syphilis in the absence of an equipped laboratory, which is the situation in many low income countries.
Cite this paper
Mugondozi, R. B. , Mohilo, G. M. and Nyamalyongo, M. M. (2021). Screening for Syphilis in Pregnant Women in Resource-Limited Environment: Which Approach Is Effective? Case Report. Open Access Library Journal, 8, e7093. doi: http://dx.doi.org/10.4236/oalib.1107093.
Stafford, I.A., Berra, A., Minard, C.G., Fontenot, V., Kopkin, R.H., Rodrigue, E., et al. (2019) Challenge in the Contemporary Management of Syphilis among Pregnant Women in New Orleans, LA. Infectious Diseases in Obstetrics and Gynecology, 2019, Article ID: 2613962. https://doi.org/10.1155/2019/2613962
Assefa, A. (2014) A Three Year Retrospective Study on Seroprevalence of Syphilis among Pregnant Women at Gondar University Teaching, Ethiopia. African Health Sciences, 14, 119-124. https://doi.org/10.4314/ahs.v14i1.18
Pedreira de Cerqueira, L.R., Monteiro, D.L.M., Taquette, S.R., Rodrigues, N.C.P., Trajano, A.J.B., Monteiro de Souza, F., et al. (2017) The Magnitude of Syphilis: From Prevalence to Vertical Transmission. Revista do Instituto de Medicina Tropical de S？o Paulo, 59, e78. https://doi.org/10.1590/s1678-9946201759078
Benedetti, K.C.S.V., Ribeiro, A.D.D.C., Queiroz, J.H.F.S., Melo, A.B.D., Batista, R.B., Delgado, F.M., et al. (2019) High Prevalence of Syphilis and Inadequate Prenatal Care in Brazilian Pregnant Women: A Cross-Sectional Study. American Journal of Tropical Medicine and Hygiene, 101, 761-766.
https://doi.org/10.4269/ajtmh.18-0912
Hussen, S. and Tadesse, B.T. (2019) Prevalence of Syphilis among Pregnant Women in Sub-Saharan Africa: A Systematic Review and Meta-Analysis. BioMed Research International, 2019, Article ID: 4562385. https://doi.org/10.1155/2019/4562385
Warren, H.P., Cramer, R., Kidd, S. and Leichliter, J.S. (2018) State Requirements for Prenatal Syphilis Screening in the United States, 2016. Maternal and Child Health Journal, 22, 1227-1232. https://doi.org/10.1007/s10995-018-2592-0
Park, I.U., Fakile, I.U., Chow, J.M., Gustafson, K.J., Jost, H., Schapiro, J.M., et al. (2019) Performance of Treponemal Tests for the Diagnosis of Syphilis. Clinical Infectious Diseases, 68, 913-918. https://doi.org/10.1093/cid/ciy558
Shahrook, S., Mori, R., Ochirbat, T. and Gomi, H. (2014) Strategies of Testing for Syphilis during Pregnancy. Cochrane Database of Systematic Reviews.
https://doi.org/10.1002/14651858.CD010385.pub2
Negash, M., Wondmagegn, T. and Geremew, D. (2018) Comparison of RPR and ELISA with TPHA for the Diagnosis of Syphilis: Implication for Updating Syphilis Point-of-Care Tests in Ethiopia. Journal of Immunology Research, 2018, Article ID: 2978419. https://doi.org/10.1155/2018/2978419
Workowski, K.A. and Berman, S. (2010) Centers for Disease Control and Prevention (CDC). Sexually Transmitted Diseases Guidelines. MMWR Recommendations and Reports, 59, 1-110.
Trivedi, S., Taylor, M., Lamb, M.L. and Chou, D. (2020) Evaluating Coverage of Maternal Syphilis Screening and Treatment within Antenatal Care to Guide Service Improvements for Prevention of Congenital Syphilis in Countdown 2030 Countries. Journal of Global Health, 10, Article ID: 010504.
https://doi.org/10.7189/jogh.10.010504
Rowe, C.R., Newberry, D.M. and Jnah, A.J. (2018) Congenital Syphilis: A Discussion of Epidemiology, Diagnosis, Management, and Nurses’ Role in Early Identification and Treatment. Advances in Neonatal Care, 18, 438-445.
https://doi.org/10.1097/ANC.0000000000000534
Amsalu, A., Ferede, G. and Assegu, D. (2018) High Seroprevalence of Syphilis Infection among Pregnant Women in Yiregalem Hospital Southern Ethiopia. BMC Infectious Diseases, 18, Article No. 109. https://doi.org/10.1186/s12879-018-2998-8
Swartzendruber, A., Steiner, R.J., Alder, M.R., Kamb, M.L. and Newman, L.M. (2015) Introduction of Rapid Syphilis Testing in Antenatal Care: A Systematic Review of the Impact on HIV and Syphilis Testing Uptake and Coverage. International Journal of Gynecology & Obstetrics, 130, 15-21.
https://doi.org/10.1016/j.ijgo.2015.04.008
Nwosu, B.O., Eleje, G.U., Obi-Nwosu, A.L., Ahiarakwem, I.F., Akujobi, C.N., Egwuatu, C.C., et al. (2015) Is Routine Antenatal Venereal Disease Research Laboratory Test Still Justified? Nigerian Experience. International Journal of Women’s Health, 7, 41-46. https://doi.org/10.2147/IJWH.S70442
Phang Romeo, C.C., Martyn-St James, M., Hamilton, J., Marinho, D.S., Castro, R. and Harnan, S. (2018) Rapid Diagnostic Test for Antenatal Syphilis Screening in Low-Income and Middle-Income Countries: A Systematic Review and Meta-Analysis. BMJ Open, 8, e018132. https://doi.org/10.1136/bmjopen-2017-018132
Morshed, M.G. and Singh, A.E. (2015) Recent Trend in Serologic Diagnosis of Syphilis. Clinical and Vaccine Immunology, 22, 137-147.
https://doi.org/10.1128/CVI.00681-14
Sena, A.C., White, B.L. and Sparling, A.F. (2010) Novel Treponema pallidum Serologic Tests: A Paradigm Shift in Syphilis Screening for the 21st Century. Clinical Infectious Diseases, 51, 700-708. https://doi.org/10.1086/655832
Rac, M.W., Revell, P.A. and Eppes, C.S. (2017) Syphilis during Pregnancy: A Preventable Threat to Maternal-Fetal Health. American Journal of Obstetrics and Gynecology, 216, 352-363. https://doi.org/10.1016/j.ajog.2016.11.1052
Bazzo, M.L., da Motta, L.R., Rudolf-Oliveira, R.C.M., Bigolin, A., Golfetto, L., Mesquita, F., et al. (2017) Evaluation of Seven Rapids Tests for Syphilis Available in Brazil Using Defibrinated Plasma Panels. Sexually Transmitted Infections, 93, 46-50. https://doi.org/10.1136/sextrans-2017-053177
