Three-dimensional (3D) genome structure plays an important role in the regulation of gene expression. Alteration of 3D genome structure can change cell’s gene expression pattern that causes cellular function change and thus could be used as a novel therapy for treating many diseases including COVID-19. Genotoxic drug is the only drug that could be used to alter 3D genome structure. Since at present no purpose-made non-carcinogenic genotoxic drugs for altering genome structure are available and fighting COVID-19 must be done without delay, it is possible to repurpose some old drugs as non-carcinogenic genotoxic drugs that can be used to reduce target cell’s susceptibility to SARS- CoV-2 which causes COVID-19 and to modulate immune cell’s response to SARS-CoV-2 infection through altering 3D genome structures in target cells and immune cells.
Cite this paper
Li, G. (2020). Non-Carcinogenic Genotoxic Drugs Could Be Used to Prevent and Treat COVID-19. Open Access Library Journal, 7, e6536. doi: http://dx.doi.org/10.4236/oalib.1106536.
Li, R., Liu, Y., Hou, Y., Gan, J., Wu, P. and Li, C. (2018) 3D Genome and Its Disorganization in Diseases. Cell Biology Toxicology, 34, 351-365.
https://doi.org/10.1007/s10565-018-9430-4
Anania, C. and Lupiá？ez, D.G. (2020) Order and Disorder: Abnormal 3D Chromatin Organization in Human Disease. Brief Funct Genomics, 19, 128-138.
https://doi.org/10.1093/bfgp/elz028
Swift, L.H. and Golsteyn, R.M. (2014) Genotoxic Anti-Cancer Agents and Their Relationship to DNA Damage, Mitosis, and Checkpoint Adaptation in Proliferating Cancer Cells. International Journal of Molecular Sciences, 15, 3403-3431.
https://doi.org/10.3390/ijms15033403
Li, G.D. (2020) Targeting Three-Dimensional Genome Architecture Might Be One of the Mechanisms of Chloroquine’s Diverse Therapeutic Actions. Open Access Library Journal, 7, e6340. https://doi.org/10.4236/oalib.1106340
Chatterjee, T., Muhkopadhyay, A., Khan, K.A. and Giri, A.K. (1998) Comparative Mutagenic and Genotoxic Effects of Three Antimalarial Drugs, Chloroquine, Primaquine and Amodiaquine. Mutagenesis, 13, 619-624.
https://doi.org/10.1093/mutage/13.6.619
Xamena, N., Creus, A., Velázquez, A. and Marcos, R. (1985) Testing of Chloroquine and Quinacrine for Mutagenicity in Drosophila Melanogaster. Mutation Research, 158, 177-180. https://doi.org/10.1016/0165-1218(85)90081-3
Isidori, M., Lavorgna, M., Nardelli, A., Pascarella, L. and Parrella, A. (2005) Toxic and Genotoxic Evaluation of Six Antibiotics on Non-Target Organisms. Science of the Total Environment, 346, 87-98. https://doi.org/10.1016/j.scitotenv.2004.11.017
Perna-Barrull, D., Rodriguez-Fernandez, S., Pujol-Autonell, I., Gieras, A., Ampudia- Carrasco, R.M., Villalba, A., Glau, L., Tolosa, E. and Vives-Pi, M. (2019) Prenatal Betamethasone Interferes with Immune System Development and Alters Target Cells in Autoimmune Diabetes. Scientific Reports, 9, Article No. 1235.
https://doi.org/10.1038/s41598-018-37878-9
Singh, H., Singh, J.R., Dhillon, V.S., Bali, D. and Paul, H. (1994) In Vitro and in Vivo Genotoxicity Evaluation of Hormonal Drugs. II. Dexamethasone. Mutation Research, 308, 89-97. https://doi.org/10.1016/0027-5107(94)90201-1
Marchwicka, A., Cebrat, M., Sampath, P., Snie？ewski, L. and Marcinkowska, E. (2014) Perspectives of Differentiation Therapies of Acute Myeloid Leukemia: The Search for the Molecular Basis of Patients’ Variable Responses to 1,25-Dihydroxyvitamin D and Vitamin D Analogs. Frontiers in Oncology, 4, 125.
https://doi.org/10.3389/fonc.2014.00125
Nefi？, H. (2008) The Genotoxicity of Vitamin C in Vitro. Bosnian Journal of Basic Medical Sciences, 8, 141-146. https://doi.org/10.17305/bjbms.2008.2969
McChesney, E.W. (1983) Animal Toxicity and Pharmacokinetics of Hydroxychloro- quine Sulfate. The American Journal of Medicine, 75, 11-18.
https://doi.org/10.1016/0002-9343(83)91265-2
Millán-O？ate, J., Millan, W., Mendoza, L.A., et al. (2020) Successful Recovery of COVID-19 Pneumonia in a Patient from Colombia after Receiving Chloroquine and Clarithromycin. Annals of Clinical Microbiology and Antimicrobials, 19, 16.
https://doi.org/10.1186/s12941-020-00358-y
Li, G.D. (2019) Flexible Cancer-Associated Chromatin Configuration (CACC) Might Be the Fundamental Reason Why Cancer Is So Difficult to Cure. Open Access Library Journal, 6, e5531. https://doi.org/10.4236/oalib.1105531
