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Optimization of Enzymatic Synthesis of Neryl Acetate in a Solvent Free System

DOI: 10.4236/oalib.1106254, PP. 1-13

Subject Areas: Chemical Engineering & Technology, Biological Engineering

Keywords: Nerol, Neryl Acetate, Kinetics, Lipase Catalysis, Transesterification

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Abstract

Synthesis of valuable flavour and fragrance compounds is one of the intense applications of lipase-catalysed transesterification. This paper demonstrated application of Novozyme 435 to the synthesis of neryl acetate in a solvent free system. Response surface methodology (RSM) complemented by central com-posite design (CCD) was used to evaluate the effect of various process param-eters on reaction conversion. The results showed that 91.6% conversion of nerol with 100% selectivity to neryl acetate was obtained under the conditions of 1:12.6 mole ratio of nerol to ethyl acetate, 2.6% (w/w) Novozyme 435 at 52.7?C for 2 h. From the kinetic study, it was verified that the reaction followed a ternary complex mechanism with inhibition by ethyl acetate. The process was green, clean and useful to the perfume and flavour industries.

Cite this paper

Jiang, C. and Cheng, G. (2020). Optimization of Enzymatic Synthesis of Neryl Acetate in a Solvent Free System. Open Access Library Journal, 7, e6254. doi: http://dx.doi.org/10.4236/oalib.1106254.

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