The appearance and diffusion of antibiotic resistance are at the moment seen as an inevitable characteristic of bacterial development succeeding the consumption of antibiotics. This spectacular event is completely clarified by the link present among the manifestation of resistances and the consumption of antibiotics. In terms of mechanisms, the augmenting appearance of antibiotic-resistant bacteria (ARB) has been largely assigned to the selection of resistant variants that pre-exist in sensitive communities. Lately, Merlin [1] published an excellent review on the secondary influences of antibiotics at sub-inhibitory levels and trace metal elements, which obviously call attention to the reality that the antibiotic resistance danger has not to be related to the only antibiotic therapy applications, and must to some extent be viewed as a multifactorial issue where co-selection and stimulation of horizontal gene transfer as well completely applies. This work focuses on the main conclusions of Merlin [1] report. More in-depth epidemiological investigations have to let defining the range of these secondary impacts outside the scene of a Petri dish and may interpret why many antibiotic resistances run away any decrease of presence while lowering the corresponding antibiotic consumption. In addition, defining thoroughly which antibiotic molecules manifest secondary influences, and at which levels, would be a supplementary stage toward antibiotic hazard evaluation, whether for therapeutic applications or for the impact of antibiotics once liberated in the downstream mediums.
Cite this paper
Ghernaout, D. (2020). Should We Forbid the Consumption of Antibiotics to Stop the Spread of Resistances
in Nature?. Open Access Library Journal, 7, e6138. doi: http://dx.doi.org/10.4236/oalib.1106138.
Merlin, C. (2020) Reducing the Consumption of Antibiotics: Would That Be Enough to Slow down the Dissemination of Resistances in the Downstream Environment? Frontiers in Microbiology, 11, 33. https://doi.org/10.3389/fmicb.2020.00033
Courvalin, P. (2005) Antimicrobial Drug Resistance: “Prediction Is Very Difficult, Especially about the Future”. Emerging Infectious Diseases, 11, 1503-1506. https://doi.org/10.3201/eid1110.051014
Furuya, E.Y. and Lowy, F.D. (2006) Antimicrobial-Resistant Bacteria in the Community Setting. Nature Reviews Microbiology, 4, 36-45. https://doi.org/10.1038/nrmicro1325
Davies, J. (2007) Microbes Have the Last Word. A Drastic Re-Evaluation of Antimicrobial Treatment Is Needed to Overcome the Threat of Antibiotic-Resistant Bacteria. EMBO Reports, 8, 616-621. https://doi.org/10.1038/sj.embor.7401022
Davies, J. and Davies, D. (2010) Origins and Evolution of Antibiotic Resistance. Microbiology and Molecular Biology Reviews, 74, 417-433. https://doi.org/10.1128/MMBR.00016-10
Ghernaout, D. and Elboughdiri, N. (2020) Removing Antibiotic-Resistant Bacteria (ARB) Carrying Genes (ARGs): Challenges and Future Trends. Open Access Library Journal, 7, e6003. https://doi.org/10.4236/oalib.1106003
Andersson, D.I. and Hughes, D. (2014) Microbiological Effects of Sublethal Levels of Antibiotics. Nature Reviews Microbiology, 12, 465-478. https://doi.org/10.1038/nrmicro3270
EUR-Lex (2018) European Parliament Legislative Resolution of 25 October 2018 on the Proposal for a Regulation of the European Parliament and of the Council on Veterinary Medicinal Products (Document P8_TA(2018)0421). https://eur-lex.europa.eu/legal-content/FR/TXT/?uri=EP%3AP8_TA%282018%290421
WHO (2017) Global Framework for Development & Stewardship to Combat Antimicrobial Resistance. http://www.who.int/antimicrobial-resistance/global-action-plan/UpdatedRoadmap-Global-Framework-for-Development-Stewardship-to-combatAMR_2017_11_03.pdf?ua=1
ECDC (European Centre for Disease Prevention and Control). Antimicrobial Consumption—Annual Epidemiological Report for 2017. https://www.ecdc.europa.eu/en/publications-data/antimicrobialconsumption-annual-epidemiological-report-2017
WHO (2018) Tackling Antimicrobial Resistance Together. Working Paper 1.0: Multisectoral Coordination. https://www.who.int/antimicrobial-resistance/publications/workingpaper1multisectoralcoordinationAMR/en/
ESVAC (European Surveillance of Veterinary Antimicrobial Consumption) (2018) Sales of Veterinary Antimicrobial Agents in 30 European Countries in 2016. https://www.ema.europa.eu/en/documents/report/sales-veterinary-antimicrobial-agents-30-european-countries-2016-trends-2010-2016-eighth-esvac_en.pdf
Ecoantibio (2017) écoantibio 2: The French National Plan for the Reduction of the Risks of Antimicrobial Resistance in Veterinary Medicine. https://agriculture.gouv.fr/le-plan-ecoantibio-2-2017-2021
RESAPATH (2016) French Surveillance Network for Antimicrobial Resistance in Pathogenic Bacteria of Animal Origin. 2016 Annual Report. https://www.anses.fr/en/system/files/LABO-Ra-Resapath2016EN.pdf
Santé Publique France (2018) Consommation d’antibiotiques et résistance aux antibiotiques en France: Une infection évitée, c’est un antibiotique préservé! https://www.santepubliquefrance.fr/maladies-ettraumatismes/infections-associees-aux-soins-et-resistance-aux-antibiotiques/resistance-aux-antibiotiques/documents/rapport-synthese/consommationd-antibiotiques-et-resistance-aux-antibiotiques-en-france-une-infectionevitee-c-est-un-antibiotique-preserve
Bourély, C., Chauvin, C., Jouy, é., Cazeau, G., Jarrige, N. and Leblond, A. (2018) Comparative Epidemiology of E. coli Resistance to Third-Generation Cephalosporins in Diseased Food-Producing Animals. Veterinary Microbiology, 223, 72-78. https://doi.org/10.1016/j.vetmic.2018.07.025
EFSA (European Food Safety Agency) (2018) The European Union Summary Report on Antimicrobial Resistance in Zoonotic and Indicator Bacteria from Humans, Animals and Food in 2016. https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2018.5182
Seppala, H., Klaukka, T., Vuopio-Varkila, J., Muotiala, A., Helenius, H. and Lager, K. (1997) The Effect of Changes in the Consumption of Macrolide Antibiotics on Erythromycin Resistance in Group A Streptococci in Finland. The New England Journal of Medicine, 337, 441-446. https://doi.org/10.1056/NEJM199708143370701
Aarestrup, F.M., Seyfarth, A.M., Emborg, H.-D., Pedersen, K., Hendriksen, R.S. and Bager, F. (2001) Effect of Abolishment of the Use of Antimicrobial Agents for Growth Promotion on Occurrence of Antimicrobial Resistance in Fecal Enterococci from Food Animals in Denmark. Antimicrobial Agents and Chemotherapy, 45, 2054-2059. https://doi.org/10.1128/AAC.45.7.2054-2059.2001
Dutil, L., Irwin, R., Finley, R., Ng, L.K., Avery, B. and Boerlin, P. (2010) Ceftiofur Resistance in Salmonella enterica Serovar Heidelberg from Chicken Meat and Humans, Canada. Emerging Infectious Diseases, 16, 48-54. https://doi.org/10.3201/eid1601.090729
Lai, C.-C., Wang, C.-Y., Chu, C.-C., Tan, C.-K., Lu, C.-L. and Lee, Y.-C. (2011) Correlation between Antibiotic Consumption and Resistance of Gram Negative Bacteria Causing Healthcare-Associated Infections at a University Hospital in Taiwan from 2000 to 2009. Journal of Antimicrobial Chemotherapy, 66, 1374-1382. https://doi.org/10.1093/jac/dkr103
Altunsoy, A., Aypak, C., Azap, A., Erg?nül, ?. and Balik, I. (2011) The Impact of a Nationwide Antibiotic Restriction Program on Antibiotic Usage and Resistance against Nosocomial Pathogens in Turkey. International Journal of Medical Sciences, 8, 339-344. https://doi.org/10.7150/ijms.8.339
Kim, B., Kim, Y., Hwang, H., Kim, J., Kim, S.W. and Bae, I.G. (2018) Trends and Correlation between Antibiotic Usage and Resistance Pattern among Hospitalized Patients at University Hospitals in Korea, 2004 to 2012: A Nationwide Multicenter Study. Medicine, 97, e13719. https://doi.org/10.1097/MD.0000000000013719
Ghernaout, D., Naceur, M.W. and Aouabed, A. (2011) On the Dependence of Chlorine By-Products Generated Species Formation of the Electrode Material and Applied Charge during Electrochemical Water Treatment. Desalination, 270, 9-22.
Ghernaout, D., Alghamdi, A., Aichouni, M. and Touahmia, M. (2018) The Lethal Water Tri-Therapy: Chlorine, Alum, and Polyelectrolyte. World Journal of Applied Chemistry, 3, 65-71. https://doi.org/10.1016/j.desal.2011.01.010
Ghernaout, D. and Elboughdiri, N. (2020) Is Not It Time to Stop Using Chlorine for Treating Water? Open Access Library Journal, 7, e6007. https://doi.org/10.11648/j.wjac.20180302.14
Ghernaout, D. and Ghernaout, B. (2010) From Chemical Disinfection to Electrodisinfection: The Obligatory Itinerary? Desalination and Water Treatment, 16, 156-175. https://doi.org/10.5004/dwt.2010.1085
Boucherit, A., Moulay, S., Ghernaout, D., Al-Ghonamy, A.I., Ghernaout, B., Naceur, M.W., Ait Messaoudene, N., Aichouni, M., Mahjoubi, A.A. and Elboughdiri, N.A. (2015) New Trends in Disinfection By-Products Formation upon Water Treatment. Journal of Research & Developments in Chemistry, 2015, Article ID: 628833. https://doi.org/10.5171/2015.628833
Ghernaout, D., Aichouni, M. and Touahmia, M. (2019) Mechanistic Insight into Disinfection by Electrocoagulation—A Review. Desalination and Water Treatment, 141, 68-81. https://doi.org/10.5004/dwt.2019.23457
Ghernaout, D., Alghamdi, A. and Ghernaout, B. (2019) Microorganisms’ Killing: Chemical Disinfection vs. Electrodisinfection. Applied Engineering, 3, 13-19.
Ghernaout, D. (2019) Electrocoagulation and Electrooxidation for Disinfecting Water: New Breakthroughs and Implied Mechanisms. Applied Engineering, 3, 125-133.
Haenni, M., Bour, M., Chatre, P., Madec, J.-Y., Plésiat, P. and Jeannot, K. (2017) Resistance of Animal Strains of Pseudomonas aeruginosa to Carbapenems. Frontiers in Microbiology, 8, 1847. https://doi.org/10.3389/fmicb.2017.01847
Collignon, P., Beggs, J.J., Walsh, T.R., Gandra, S. and Laxminarayan, R. (2018) Anthropological and Socioeconomic Factors Contributing to Global Antimicrobial Resistance: A Univariate and Multivariable Analysis. The Lancet Planetary Health, 2, e398-e405. https://doi.org/10.1016/S2542-5196(18)30186-4
OIE (World Organization for Animal Health) (2018) OIE List of Antimicrobial Agents of Veterinary Importance. https://www.oie.int/fileadmin/Home/eng/Our_scientific_expertise/docs/pdf/AMR/A_OIE_List_antimicrobials_May2018.pdf
Scornec, H., Bellanger, X., Guilloteau, H., Groshenry, G. and Merlin, C. (2017) Inducibility of Tn916 Conjugative Transfer in Enterococcus faecalis by Subinhibitory Concentrations of Ribosome-Targeting Antibiotics. Journal of Antimicrobial Chemotherapy, 72, 2722-2728. https://doi.org/10.1093/jac/dkx202
Hasman, H., Kempf, I., Chidaine, B., Cariolet, R., Ersb?ll, A.K. and Houe, H. (2006) Copper Resistance in Enterococcus faecium, Mediated by the tcrB Gene, Is Selected by Supplementation of Pig Feed with Copper Sulfate. Applied and Environmental Microbiology, 72, 5784-5789. https://doi.org/10.1128/AEM.02979-05
Yin, Y., Gu, J., Wang, X., Song, W., Zhang, K. and Sun, W. (2017) Effects of Copper Addition on Copper Resistance, Antibiotic Resistance Genes, and intl1 during Swine Manure Composting. Frontiers in Microbiology, 8, 344. https://doi.org/10.3389/fmicb.2017.00344
Van Alen, S., Kaspar, U., Idelevich, E.A., K?ck, R. and Becker, K. (2018) Increase of Zinc Resistance in German Human Derived Livestock-Associated MRSA between 2000 and 2014. Veterinary Microbiology, 214, 7-12. https://doi.org/10.1016/j.vetmic.2017.11.032