Chitooligosaccharides (COS) has an effect to reduce blood glucose and blood lipids and is used in adjuvant therapy for diabetes mellitus (DM), which is closely associated with gut microbiota. Therefore, it is worthy investigating whether COS exerts its effect via the gut microbiota. In this paper, we studied the response of gut microbiota in diabetic mice to COS, using the high-throughput sequencing technology. We found that COS had significant effect on the community structure of gut microbiota in mice though it had no significant effect on the α-diversity of gut microbiota; the abundance of Ac-tinobacteria was increased significantly in the gut tract of mice fed with COS (P < 0.05); the abundance of Corynebacteriaceae significantly increased in di-abetic mice fed with COS (P < 0.05); at OTU level, the abundance of 13 OTUs of Bacteroidales S24-7 group decreased significantly (P < 0.05) while that of Lachnospiraceae increased significantly (P < 0.05) in diabetic mice intra-gastrically administered with COS. The results of our experiment suggest that the effect of COS to reduce blood glucose in diabetic mice might be produced by decreasing the abundance of Bacteroidetes and increasing that of Firmicutes and Actinobacteria.
Cite this paper
Wang, X. , Hu, Q. and Dong, C. (2019). The Effect of Chitooligosaccharides on Gut Microbiota in Diabetic Mice. Open Access Library Journal, 6, e5961. doi: http://dx.doi.org/10.4236/oalib.1105961.
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