In this article, it is hypothesized a new mechanism for the formation of stable remote memory in brain comprising the important memory acquired during childhood and the common words in language. It has been demonstrated that the memory forms concurrently at both homosynaptic long term potentiation (LTP) and heterosynaptic long term depression (LTD). It is pointed out that the repeated LTD may result in neuronal degeneration as evidenced at molecular and cellular level, becoming long lasting throughout the lifespan. Besides, it is further supported by the consequent storage of remote memory directly on the information pathway, as evidenced by the degenerative ocular dominance plasticity and the storage of common words/grammar within the linguistic areas of brain. Accordingly, it is herein completed the hypothesis on the formation of remote memory from the heterosynaptic LTD-mediated neuronal degeneration in brain so long as the homosynaptic pathway does not degenerate from such causes as aging and so on, while supplementing a new form of neuronal plasticity for memory in addition to the contemporary LTP and LTD.
Cite this paper
Cai, Z. (2019). Hypothesis on Remote Memory Forming from Heterosynaptic LTD-Mediated Neuronal Degeneration. Open Access Library Journal, 6, e5442. doi: http://dx.doi.org/10.4236/oalib.1105442.
Cai, Z.-J. (2018) The Limbic-Reticular Coupling Theory of Memory Processing in the Brain and Its Greater Compatibility Over Other Theories. Dementia & Neuropsychologia, 12, 105-113. https://doi.org/10.1590/1980-57642018dn12-020002
Moscovitch, M., Rosenbaum, R.S., Gil-boa, A., Addis, D.R., Westmacott, R., Grady, C., McAndrews, M.P., Levine, B., Black, S., Winocur, G. and Nadel, L. (2005) Func-tional Neuroanatomy of Remote Episodic, Semantic and Spatial Memory: A Unified Account Based on Multiple Trace Theory. Journal of Anatomy, 207, 35-66. https://doi.org/10.1111/j.1469-7580.2005.00421.x
Muller, D., Hefft, S. and Figurov, A. (1995) Heterosynaptic Interactions between LTP and LTD in CA1 Hippocampal Slices. Neuron, 14, 599-605. https://doi.org/10.1016/0896-6273(95)90316-X
Abraham, W.C., Mason-Parker, S.E., Irvine, G.I., Logan, B. and Gill, A.I. (2006) Induction and Activity-Dependent Reversal of Persistent LTP and LTD in Lateral Perforant Path Synapses in Vivo. Neu-robiology of Learning and Memory, 86, 82-90. https://doi.org/10.1016/j.nlm.2005.12.007
Jedlicka, P., Benuskova, L. and Abraham, W.C. (2015) A Volt-age-Based STDP Rule Combined with Fast BCM-Like Metaplasticity Accounts for LTP and Concurrent “Heterosynaptic” LTD in the Dentate Gyrus in Vivo. PLOS Computational Biology, 11, e1004588. https://doi.org/10.1371/journal.pcbi.1004588
Kosub, K.A., Do, V.H. and Derrick, B.E. (2005) NMDA Receptor Antagonists Block Heterosynaptic Long-Term Depression (LTD) But Not Long-Term Potentiation (LTP) in the CA3 Region Following Lateral Perforant Path Stimulation. Neuroscience Letters, 374, 29-34. https://doi.org/10.1016/j.neulet.2004.10.028
Abraham, W.C., Logan, B., Wolff, A. and Benuskova, L. (2007) “Heterosynaptic” LTD in the Dentate Gyrus of Anesthetized Rat Requires Homosynaptic Activity. Journal of Neurophysiology, 98, 1048-1051. https://doi.org/10.1152/jn.00250.2007
Chen, J., Tan, Z., Zeng, L., Zhang, X., He, Y., Gao, W., Wu, X., Li, Y., Bu, B., Wang, W. and Duan, S. (2013) Heterosynaptic Long-Term Depression Mediated by ATP Released from Astrocytes. Glia, 61, 178-191. https://doi.org/10.1002/glia.22425
Arami, M.K., Sohya, K., Sarihi, A., Jiang, B., Yanagawa, Y. and Tsumoto, T. (2013) Recip-rocal Homosynaptic and Heterosynaptic Long-Term Plasticity of Corticogeniculate Projection Neurons in Layer VI of the Mouse Visual Cortex. The Journal of Neuroscience, 33, 7787-7798. https://doi.org/10.1523/JNEUROSCI.5350-12.2013
Chiu, C.Q., Puente, N., Grandes, P. and Castillo, P.E. (2010) Dopaminergic Modulation of Endocannabinoid-Mediated Plasticity at GABAergic Synapses in the Prefrontal Cortex. The Journal of Neuroscience, 30, 7236-7248. https://doi.org/10.1523/JNEUROSCI.0736-10.2010
Hansen, N. and Manahan-Vaughan, D. (2015) Locus Coeruleus Stimulation Facilitates Long-Term Depression in the Dentate Gyrusthat Requires Activation of β-Adrenergic Receptors. Cerebral Cortex, 25, 1889-1896. https://doi.org/10.1093/cercor/bht429
Toyoda, H. (2018) Nicotine Facilitates Synaptic Depression in Layer V Pyramidal Neurons of the Mouse Insular Cortex. Neuroscience Letters, 672, 78-83. https://doi.org/10.1016/j.neulet.2018.02.046
Sidorov, M.S., Kaplan, E.S., Osterweil, E.K., Lindemann, L. and Bear, M.F. (2015) Metabotropic Glutamate Receptor Signaling Is Required for NMDA Receptor-Dependent Ocular Dominance Plasticity and LTD in Visual Cortex. Proceedings of the National Academy of Sciences of the United States of America, 112, 12852-12857. https://doi.org/10.1073/pnas.1512878112
Jenks, K.R., Kim, T., Pastuzyn, E.D., Okuno, H., Taibi, A.V., Bito, H., Bear, M.F. and Shepherd, J.D. (2017) Arc Restores Juvenile Plasticity in Adult Mouse Visual Cortex. Proceedings of the National Academy of Sciences of the United States of America, 114, 9182-9187. https://doi.org/10.1073/pnas.1700866114
Czarnecki, A., Birtoli, B. and Ulrich, D. (2007) Cellular Mechanisms of Burst Firing-Mediated Long-Term Depression in Rat Neocortical Pyramidal Cells. The Journal of Physiology, 578, 471-479. https://doi.org/10.1113/jphysiol.2006.123588
González-Rueda, A., Pedrosa, V., Feord, R.C., Clopath, C. and Paulsen, O. (2018) Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave- Sleep-Like Activity in Vivo. Neuron, 97, 1244-1252.e5. https://doi.org/10.1016/j.neuron.2018.01.047
Inostroza, M. and Born, J. (2013) Sleep for Preserving and Transforming Episodic Memory. Annual Review of Neuroscience, 36, 79-102. https://doi.org/10.1146/annurev-neuro-062012-170429
Hunt, D.L., Linaro, D., Si, B., Romani, S. and Spruston, N. (2018) A Novel Pyramidal Cell Type Promotes Sharp-Wave Synchronization in the Hippocampus. Nature Neuroscience, 21, 985-995. https://doi.org/10.1038/s41593-018-0172-7
