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A Clinical Triad of Digital Clubbing, “Arthritis” and Ossifying Periostitis in a Man: Case Report

DOI: 10.4236/oalib.1105101, PP. 1-7

Subject Areas: Orthopedics, Anaesthesiology & Pain Management, Internal Medicine, Rheumatology, Radiology & Medical Imaging

Keywords: Hypertrophic Osteoarthropathy, Pachydermoperiostosis, Cutis Verticis Gyrate, Periosteal Reaction, Clubbing

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A 49 year old gentleman presented with intermittent bilateral knee swelling for the past 37 years and was eventually diagnosed as primary hypertrophic osteoarthropathy after secondary forms were excluded. This case illustrates that the disease can present during childhood with an insidious onset and progressively become more severe and that is when medical attention is sought. Furthermore, the patient did not voluntarily report his skin changes as he considered the slow progressive changes as normal. We report a case of primary hypertrophic osteoarthropathy, its clinical presentation, imaging findings and therapeutic treatment. It is a rare differential diagnosis for chronic joint pain and swelling.

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Ng, C. and Loh, Y. (2019). A Clinical Triad of Digital Clubbing, “Arthritis” and Ossifying Periostitis in a Man: Case Report. Open Access Library Journal, 6, e5101. doi:


[1]  Uppal, S., et al. (2008) Mutations in 15-Hydroxyprostaglandin Dehydrogenase Cause Primary Hypertrophic Osteoarthropa-thy. Nature Genetics, 40, 789-793.
[2]  Gómez Rodríguez, N., Ibánez Ruán, J. and González Pérez, M. (2009) Primary Hypertrophic Osteoarthropathy (Pachydermoperiostosis). Report of 2 Familial Cases and Literature Review. Reumatología Clínica, 5, 259-263.
[3]  James, W., Berger, T. and Elston, D. (2005) Andrews’ Diseases of the Skin: Clinical Dermatology. 10th Edition, Saunders, 572.
[4]  Fauci, A.S., et al., Eds. (2008) Harrison’s Principles of Internal Medicine. McGraw-Hill Medical, New York.
[5]  Touraine, A., Solente, G. and Gole, L. (1935) Un syndrome osteodermopathique: La pachydermie plicaturee avec pachyperiostose des extremites. La Presse Médicale, 43, 1820-1824.
[6]  Karnan, S., Krishnamoorthy, V., Ethiraj, P. and Sathynathan, B.P. (2012) Touraine-Solente-Gole Syndrome. The Complete form Needs to Be Recognised. Indian Journal of Nuclear Medicine, 27, 201-204.
[7]  Jajic, I. and Jajic, Z. (1992) Prevalence of Primary Hypertrophic Osteoarthropathy. Clinical and Experimental Rheumatology, 10, 73.
[8]  Castori, M., et al. (2005) Pachydermoperiostosis: An Update. Clinical Genetics, 68, 477-486.
[9]  Offret, H., Venencie, P.Y., Fain, J., Quillard, J. and Badarani, N. (1996) Involvement of the Connective Tissue of the Eyelids in Pachydermoperiostosis. Journal Francais D’Ophtalmologie, 19, 64-68. [Article in French].
[10]  Kabashima, K., Sakabe, J., Yoshiki, R., Tabata, Y., Kohno, K. and Tokura, Y. (2010) Involvement of Wnt Signaling in Dermal Fibroblasts. The American Journal of Pathology, 176, 721-732.
[11]  Bauer, J.S. (2008) Hypertrophic Osteoarthropathy. In: Baert, A.L., Ed., Encyclopedia of Diagnostic Imaging, 1st Edition, Springer, Berlin New York Heidelberg, 929-931.
[12]  Martinez-Lavin, M., Vargas, A. and Rivera-Vinas, M. (2008) Hypertrophic Osteoarthropathy: A Palindrome with a Pathogenic Connotation. Current Opinion in Rheumatology, 20, 88-91.
[13]  Narayanan, S., Mohamed Gani, V.M. and Sundararaju, V. (2010) Primary Hypertrophic Osteoarthropathy with Hypertrophic Gastropathy. Journal of Clinical Rheumatology, 16, 190-192.


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