Objective: The aim of
this study was to examine the effects of high-intensity intermittent exercise
(HIIE) on features of immunometabolism by comparing elderly female sarcopenia
and non-sarcopenia in elderly female patients with type 2 diabetes (T2MD).
Differences in metabolism and inflammatory responses between the two groups
were compared. Methods: 6 elderly female sarcopenia patients with T2MD served
as sarcopenia group, and 7 elderly female non-sarcopenia patients with T2MD
served as control subjects. Using dual energy X-ray absorptiometry (DXA) to the
subjects’ body fat compositions was measured. All subjects underwent three
high-intensity Wingate tests at 5-minute intervals, and peak and average power
during each Wingate trial were recorded. Blood samples were collected
immediately after the test was completed. Peripheral blood levels of the
inflammatory cytokine IL-6, which is related to mitosis, were measured in both
groups before and after HIIE by ELISA. Results: The non-sarcopenia group had a
higher metabolic rate than the sarcopenia group. Sarcopenia had no significant
effect on the differences in the IL-6 inflammatory response (p = 0.430).
Conclusion: The metabolic energy and rate during HIIE differed between the two
groups. Non-sarcopenia group exhibited higher metabolic levels. No significant
difference between groups was observed in the IL-6 inflammatory response during
Cite this paper
Liu, Z. (2018). Metabolic and IL-6-Induced Inflammatory Responses in High-Intensity Intermittent Exercise among Type 2 Diabetes Patients with Sarcopenia. Open Access Library Journal, 5, e4622. doi: http://dx.doi.org/10.4236/oalib.1104622.
Jue, T., Rothman, D.L., Shulman, G.I., Tavitian, B.A., DeFronzo, R.A. and Shulman R.G. (1989) Direct Observation of Glycogen Synthesis in Human Muscle with 13C NMR. Proceedings of the National Academy of Sciences of the United States of America, 86, 4489-4491. https://doi.org/10.1073/pnas.86.12.4489
Richter, E.A., Sonne, B., Christensen, N.J. and Galbo, H. (1981) Role of Epinephrine for Muscular Glycogenolysis and Pancreatic Hormonal Secretion in Running Rats. American Journal of Physiology, 240, E526-E532. https://doi.org/10.1152/ajpendo.1981.240.5.E526
Pillon, N.J., Bilan, P.J., Fink, L.N. and Klip, A. (2013) Cross-Talk between Skeletal Muscle and Immune Cells: Muscle-Derived Mediators and Metabolic Implications. American Journal of Physiology Endocrinology & Metabolism, 304, E453-E465. https://doi.org/10.1152/ajpendo.00553.2012
Ostrowski, K., Rohde, T., Asp, S., Schjerling, P. and Pedersen, B.K. (2001) Chemokines Are Elevated in Plasma after Strenuous Exercise in Humans. European Journal of Applied Physiology, 84, 244-245. https://doi.org/10.1007/s004210170012
Ostrowski, K., Rohde, T., Zacho, M., Asp, S. and Pedersen, B.K. (2010) Evidence that Interleukin-6 Is Produced in Human Skeletal Muscle during Prolonged Running. Journal of Physiology, 508, 949-953. https://doi.org/10.1111/j.1469-7793.1998.949bp.x
Molanouri Shamsi, M., Hassan, Z.M., Quinn, L.S., Gharakhanlou, R., Baghersad, L. and Mahdavi, M. (2015) Time Course of IL-15 Expression after Acute Resistance exercise in Trained Rats: Effect of Diabetes and Skeletal Muscle Phenotype. Endocrine, 49, 396-403. https://doi.org/10.1007/s12020-014-0501-x
Steensberg, A., Keller, C., Starkie, R.L., Osada, T. and Febbraio, M.A. (2002) Pedersen BK.IL-6 and TNF-Alpha expRession in, and Release from, Contracting Human Skeletal Muscle. American Journal of Physiology Endocrinology & Metabolism, 283, E1272-1278. https://doi.org/10.1152/ajpendo.00255.2002
Kim, T.H., Choi, S.E., Ha, E.S., Jung, J.G., Han, S.J., Kim, H.J., Kim, D.J., Kang, Y. and Lee, K.W. (2013) IL-6 Induction of TLR-4 Gene Expression via STAT3 Has an Effect on Insulin Resistance in Human Skeletal Muscle．Acta Diabetologica, 50, 189-200. https://doi.org/10.1007/s00592-011-0259-z
Lira, F.S., Panissa, V.L., Julio, U.F. and Franchini, E. (2015) Differences in Metabolic and Inflammatory Responses in Lower and Upper Body High-Intensity Intermittent Exercise. European Journal of Applied Physiology, 115, 1467-1474. https://doi.org/10.1007/s00421-015-3127-7
Astorino, T.A., Allen, R.P., Jurancich, M., Roberson, D.W. and Trost, E. (2010) Effect of High-intensity Interval Training (HIIT) on Cardiovascular Function and Muscular Force: 1027: June 4 3:15 PM-3:30 PM. Medicine & Science in Sports & Exercise, 42, 138-139. https://doi.org/10.1249/01.MSS.0000386331.58054.8a
Trapp, E.G., Chisholm, D.J., Freund, J. and Boutcher, S.H. (2008) The Effects of High-Intensity Intermittent Exercise Training on Fat Loss and Fasting Insulin Levels of Young Women. International Journal of Obesity, 32, 684-691. https://doi.org/10.1038/sj.ijo.0803781
Sim, A.Y., Wallman, K.E., Fairchild, T.J. and Guelfi, K.J. (2015) Effects of High-Intensity Intermittent Exercise Training on Appetite Regulation. Medicine & Science in Sports & Exercise, 47, 2441-2449. https://doi.org/10.1249/MSS.0000000000000687
Chuensiri, N., Tanaka, H. and Suksom, D. (2015) The Acute Effects of Supramaximal High-Intensity Intermittent Exercise on Vascular Function in Lean vs. Obese Prepubescent Boys. Pediatric Exercise Science, 27, 503-509. https://doi.org/10.1123/pes.2015-0100
Terada, T., Friesen, A., Chahal, B.S., Bell, G.J., McCargar, L.J. and Boulé, N.G. (2013) Exploring the Variability in Acute Glycemic Responses to Exercise in Type 2 Diabetes. Journal of Diabetes Research, 2013, 1-6. https://doi.org/10.1155/2013/591574
Cassidy, S., Thoma, C., Hallsworth, K., Parikh, J., Hollingsworth, K.G., Taylor, R., Jakovljevic, D.G. and Trenell, M.I. (2016) High Intensity Intermittent Exercise Improves Cardiac Structure and Function and Reduces Liver Fat in Patients with Type 2 Diabetes: A Randomised Controlled Trial. Diabetologia, 59, 56-66. https://doi.org/10.1007/s00125-015-3741-2
Sculthorpe, N.F., Herbert, P. and Grace, F. (2017) One Session of High-Intensity Interval Training (HIIT) Every 5 Days, Improves Muscle Power But Not Static Balance in Lifelong Sedentary Ageing Men: A Randomized Controlled Trial. Medicine, 96, 1-8. https://doi.org/10.1097/MD.0000000000006040
Medbo, J.I. and Tabata, I. (1989) Relative Importance of Aerobic and Anaerobic Energy Release during Short-Lasting Exhausting Bicycle Exercise. Journal of Applied Physiology, 67, 1881-1886.
Stenholm, S., Maggio, M., Lauretani, F., Bandinelli, S., Ceda, G.P., Di Iorio, A., Giallauria, F., Guralnik, J.M. and Ferrucci, L. (2010) Anabolic and Catabolic Biomarkers as Predictors of Muscle Strength Decline: The InCHIANTI Study. Rejuvenation Research, 13, 3-11. https://doi.org/10.1089/rej.2009.0891
Richter, E.A., Kiens, B., Saltin, B., Christensen, N.J. and Savard, G. (1988) Skeletal Muscle Glucose Uptake during Dynamic Exercise in Humans: Role of Muscle Mass. American Journal of Physiology, 254, E555.
Gukbel, H., Okudan, N., Gül, I., Belviranli, M., Gergerlioglu, H.S. and Basaral, M.K. (2012) Effects of Repeated Bouts of Supramaximal Exercise on Plasma Adiponectin, Interleukin-6, and Tumor Necrosis Factor-α Levels in Sedentary Men. Journal of Strength & Conditioning Research, 26, 1675-1679.