All Title Author
Keywords Abstract

Publish in OALib Journal
ISSN: 2333-9721
APC: Only $99


Metabolic and IL-6-Induced Inflammatory Responses in High-Intensity Intermittent Exercise among Type 2 Diabetes Patients with Sarcopenia

DOI: 10.4236/oalib.1104622, PP. 1-11

Subject Areas: Diabetes & Endocrinology

Keywords: Sarcopenia, Type 2 Diabetes, IL-6

Full-Text   Cite this paper   Add to My Lib


Objective: The aim of this study was to examine the effects of high-intensity intermittent exercise (HIIE) on features of immunometabolism by comparing elderly female sarcopenia and non-sarcopenia in elderly female patients with type 2 diabetes (T2MD). Differences in metabolism and inflammatory responses between the two groups were compared. Methods: 6 elderly female sarcopenia patients with T2MD served as sarcopenia group, and 7 elderly female non-sarcopenia patients with T2MD served as control subjects. Using dual energy X-ray absorptiometry (DXA) to the subjects’ body fat compositions was measured. All subjects underwent three high-intensity Wingate tests at 5-minute intervals, and peak and average power during each Wingate trial were recorded. Blood samples were collected immediately after the test was completed. Peripheral blood levels of the inflammatory cytokine IL-6, which is related to mitosis, were measured in both groups before and after HIIE by ELISA. Results: The non-sarcopenia group had a higher metabolic rate than the sarcopenia group. Sarcopenia had no significant effect on the differences in the IL-6 inflammatory response (p = 0.430). Conclusion: The metabolic energy and rate during HIIE differed between the two groups. Non-sarcopenia group exhibited higher metabolic levels. No significant difference between groups was observed in the IL-6 inflammatory response during HIIE.

Cite this paper

Liu, Z. (2018). Metabolic and IL-6-Induced Inflammatory Responses in High-Intensity Intermittent Exercise among Type 2 Diabetes Patients with Sarcopenia. Open Access Library Journal, 5, e4622. doi:


[1]  Jue, T., Rothman, D.L., Shulman, G.I., Tavitian, B.A., DeFronzo, R.A. and Shulman R.G. (1989) Direct Observation of Glycogen Synthesis in Human Muscle with 13C NMR. Proceedings of the National Academy of Sciences of the United States of America, 86, 4489-4491.
[2]  Richter, E.A., Sonne, B., Christensen, N.J. and Galbo, H. (1981) Role of Epinephrine for Muscular Glycogenolysis and Pancreatic Hormonal Secretion in Running Rats. American Journal of Physiology, 240, E526-E532.
[3]  Rose, A.J. and Richter, E.A. (2005) Skeletal Muscle Glucose Uptake during Exercise: How Is It Regulated? Physiology, 20, 260-270.
[4]  Onamb, G.L., Pearson, X. and Breen, L. (2006) Wide Clinical Implementation of Insulin Resistance Syndrome? Metabolic Syndrome & Related Disorders, 4, 165-171.
[5]  Pillon, N.J., Bilan, P.J., Fink, L.N. and Klip, A. (2013) Cross-Talk between Skeletal Muscle and Immune Cells: Muscle-Derived Mediators and Metabolic Implications. American Journal of Physiology Endocrinology & Metabolism, 304, E453-E465.
[6]  Ostrowski, K., Rohde, T., Asp, S., Schjerling, P. and Pedersen, B.K. (2001) Chemokines Are Elevated in Plasma after Strenuous Exercise in Humans. European Journal of Applied Physiology, 84, 244-245.
[7]  Ostrowski, K., Rohde, T., Zacho, M., Asp, S. and Pedersen, B.K. (2010) Evidence that Interleukin-6 Is Produced in Human Skeletal Muscle during Prolonged Running. Journal of Physiology, 508, 949-953.
[8]  Molanouri Shamsi, M., Hassan, Z.M., Quinn, L.S., Gharakhanlou, R., Baghersad, L. and Mahdavi, M. (2015) Time Course of IL-15 Expression after Acute Resistance exercise in Trained Rats: Effect of Diabetes and Skeletal Muscle Phenotype. Endocrine, 49, 396-403.
[9]  Steensberg, A., Keller, C., Starkie, R.L., Osada, T. and Febbraio, M.A. (2002) Pedersen BK.IL-6 and TNF-Alpha expRession in, and Release from, Contracting Human Skeletal Muscle. American Journal of Physiology Endocrinology & Metabolism, 283, E1272-1278.
[10]  Kim, T.H., Choi, S.E., Ha, E.S., Jung, J.G., Han, S.J., Kim, H.J., Kim, D.J., Kang, Y. and Lee, K.W. (2013) IL-6 Induction of TLR-4 Gene Expression via STAT3 Has an Effect on Insulin Resistance in Human Skeletal Muscle.Acta Diabetologica, 50, 189-200.
[11]  Lira, F.S., Panissa, V.L., Julio, U.F. and Franchini, E. (2015) Differences in Metabolic and Inflammatory Responses in Lower and Upper Body High-Intensity Intermittent Exercise. European Journal of Applied Physiology, 115, 1467-1474.
[12]  Astorino, T.A., Allen, R.P., Jurancich, M., Roberson, D.W. and Trost, E. (2010) Effect of High-intensity Interval Training (HIIT) on Cardiovascular Function and Muscular Force: 1027: June 4 3:15 PM-3:30 PM. Medicine & Science in Sports & Exercise, 42, 138-139.
[13]  Trapp, E.G., Chisholm, D.J., Freund, J. and Boutcher, S.H. (2008) The Effects of High-Intensity Intermittent Exercise Training on Fat Loss and Fasting Insulin Levels of Young Women. International Journal of Obesity, 32, 684-691.
[14]  Sim, A.Y., Wallman, K.E., Fairchild, T.J. and Guelfi, K.J. (2015) Effects of High-Intensity Intermittent Exercise Training on Appetite Regulation. Medicine & Science in Sports & Exercise, 47, 2441-2449.
[15]  Chuensiri, N., Tanaka, H. and Suksom, D. (2015) The Acute Effects of Supramaximal High-Intensity Intermittent Exercise on Vascular Function in Lean vs. Obese Prepubescent Boys. Pediatric Exercise Science, 27, 503-509.
[16]  Terada, T., Friesen, A., Chahal, B.S., Bell, G.J., McCargar, L.J. and Boulé, N.G. (2013) Exploring the Variability in Acute Glycemic Responses to Exercise in Type 2 Diabetes. Journal of Diabetes Research, 2013, 1-6.
[17]  Krustrup, P., Randers, M.B., Andersen, L.J., Jackman, S.R., Bangsbo, J. and Hansen, P.R. (2013) Soccer Improves Fitness and Attenuates Cardiovascular Risk Factors in Hypertensive Men. Medicine & Science in Sports & Exercise, 45, 553-560.
[18]  Cassidy, S., Thoma, C., Hallsworth, K., Parikh, J., Hollingsworth, K.G., Taylor, R., Jakovljevic, D.G. and Trenell, M.I. (2016) High Intensity Intermittent Exercise Improves Cardiac Structure and Function and Reduces Liver Fat in Patients with Type 2 Diabetes: A Randomised Controlled Trial. Diabetologia, 59, 56-66.
[19]  Sculthorpe, N.F., Herbert, P. and Grace, F. (2017) One Session of High-Intensity Interval Training (HIIT) Every 5 Days, Improves Muscle Power But Not Static Balance in Lifelong Sedentary Ageing Men: A Randomized Controlled Trial. Medicine, 96, 1-8.
[20]  Chen, L.K., Liu, L.K., Woo, J., Assantachai, P., Auyeung, T.W., Bahyah K.S., Chou, M.Y., Chen, L.Y., Hsu, P.S., Krairit, O., Lee, J.S., Lee, W.J., Lee, Y., Liang, C.K., Limpawattana, P., Lin, C.S., Peng, L.N., Satake, S., Suzuki, T., Won, C.W., Wu, C.H., Wu, S.N., Zhang, T., Zeng, P., Akishita, M. and Arai, H. (2014) Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia. Journal of the American Medical Directors Association, 15, 95-101.
[21]  Medbo, J.I. and Tabata, I. (1989) Relative Importance of Aerobic and Anaerobic Energy Release during Short-Lasting Exhausting Bicycle Exercise. Journal of Applied Physiology, 67, 1881-1886.
[22]  Bian, A.L., Hu, H.Y. and Rong, Y.D. (2017) A Study on Relationship between Elderly Sarcopenia and Inflammatory Factors IL-6 and TNF-α. Maturitas, 22, 25.
[23]  Pereira, L.S., Narciso, F.M., Oliveira, D.M., Coelho, F.M., Souza Dda G. and Dias, R.C. (2009) Correlation between Manual Muscle Strength and Interleukin-6 (IL-6) Plasma Levels in Elderly Community-Dwelling Women. Archives of Gerontology & Geriatrics, 48, 313-316.
[24]  Stenholm, S., Maggio, M., Lauretani, F., Bandinelli, S., Ceda, G.P., Di Iorio, A., Giallauria, F., Guralnik, J.M. and Ferrucci, L. (2010) Anabolic and Catabolic Biomarkers as Predictors of Muscle Strength Decline: The InCHIANTI Study. Rejuvenation Research, 13, 3-11.
[25]  Febbraio, M.A. and Pedersen, B.K. (2002) Muscle-Derived Interleukin-6: Mechanisms for Activation and Possible Biological Roles. The FASEB Journal, 16, 1335-1347.
[26]  Pedersen, B.K. and Fischer, C.P. (2007) Beneficial Health Effects of Exercise—The Role of IL-6 as a Myokine. Trends in Pharmacological Sciences, 28, 152-156.
[27]  Shigemoto, K., Mori, S., Fukunaga, T. and Miyazaki, T. (2013) Aging Research on Muscle and Motor Neuron. Japanese Journal of Geriatrics, 50, 349-351.
[28]  Richter, E.A., Kiens, B., Saltin, B., Christensen, N.J. and Savard, G. (1988) Skeletal Muscle Glucose Uptake during Dynamic Exercise in Humans: Role of Muscle Mass. American Journal of Physiology, 254, E555.
[29]  Wang, L. and Wang, X.L. (2017) Study on Body Composition and Anaerobic Metabolism of Male Taekwondo Athletes in North University of China. Hubei Sports Science (China), 35, 869-872.
[30]  Meyer, T., Gabriel, H.H., Ratz, M., Müller, H.J. and Kindermann, W. (2001) Anaerobic Exercise Induces Moderate Acute Phaseresponse. Medicine & Science in Sports & Exercise, 33, 549-555.
[31]  Gukbel, H., Okudan, N., Gül, I., Belviranli, M., Gergerlioglu, H.S. and Basaral, M.K. (2012) Effects of Repeated Bouts of Supramaximal Exercise on Plasma Adiponectin, Interleukin-6, and Tumor Necrosis Factor-α Levels in Sedentary Men. Journal of Strength & Conditioning Research, 26, 1675-1679.


comments powered by Disqus

Contact Us


微信:OALib Journal