In recent years, sarcopenia began to receive
attention. Not only the elderly, hyperthyroidism patients also suffer from
sarcopenia. The purpose of this study is to explore the relevant factors for
sarcopenia in hyperthyroidism patients. [Methods]: Dual energy X-ray was used to detect the muscle mass
in 101 hyperthyroidism patients (23 males and 78 females, mean age 45.77 ± 15.02 years), and calculate SMI. Pearson correlation analysis was
performed to examine the relationship between SMI and Age, BMI, Fat amount, Grip, SBP, DBP, FT3, FT4, TSH, Ca, P, TC, TG, LDL-C, HDL-C, FPG, LA, IL-6, TNF-a respectively. Spearman correlation analysis
was performed to examine the relationship between gender respectively. The
influencing factors of relative SMI status were selected by stepwise regression
analysis. [Results]: Based on Pearson and Spearman analysis, Gender (r = ﹣0.567, p< 0.001), BMI (r = 0.245, p= 0.014), grip (r = 0.670, p< 0.001), TC (r = 0.221, p= 0.026), lactic acid (r = ﹣0.196, p= 0.050) is significantly correlated with sarcopenia in
hyperthyroidism patients. Stepwise regression analysis showed that there
existed the close correlations between gender, BMI, grip and SMI, Y = 4.805 ﹣ 0.985 gender 0.044 BMI 0.045 grip. [Conclusion]: As a risk of sarcopenia
in hyperthyroidism patients, there was a correlation with gender, grip strength
and BMI. Not only the elderly, young patients with hyperthyroidism should also pay
attention to sarcopenia.
Cite this paper
Liu, Z. , Xia, F. , Zhao, X. and Zhou, D. (2018). Relevant Factors for Sarcopenia in Hyperthyroidism Patients. Open Access Library Journal, 5, e4620. doi: http://dx.doi.org/10.4236/oalib.1104620.
Santilli, V., Bernetti, A., et al. (2014) Clinical Definition of Sarcopenia. Clinical Cases in Mineral and Bone Metabolism, 11, 177-180. https://doi.org/10.11138/ccmbm/2014.11.3.177
Handschin, C. and Spiegelman, B.M. (2008) The Role of Exercise and PGC1alpha in Inflammation and Chronic Disease. Nature, 454, 463-469. https://doi.org/10.1038/nature07206
Wang, J.-Y. and Wang, X.-H. (2012) Effect of p38,NF-кB and IL-6 on Pathogenesis of Sarcopenia and It’s Exercise-Induced Improvement. Journal of Shandong Institute of Physical Education and Sports, 28, 51-56.
Peterson, M.E., Castellano, C.A., et al. (2016) Evaluation of Body Weight, Body Condition, and Muscle Condition in Cats with Hyperthyroidism. Journal of Veterinary Internal Medicine, 30, 1780-1789. https://doi.org/10.1111/jvim.14591
Chen, L.K., Liu, L.K., et al. (2014) Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia. Journal of the American Medical Directors Association, 15, 95-101. https://doi.org/10.1016/j.jamda.2013.11.025
Riis, A.L., Jorgensen, J.O., et al. (2005) Whole Body and Forearm Substrate Metabolism Inhyperthyroidism: Evidence of Increased Basal Muscle Protein Breakdown. American Journal of Physiology Endocrinology Metabolism, 288, 1067-1073.
https://doi.org/10.1152/ajpendo.00253.2004
Monaco, D., Castiglioni, C., et al. (2012) Sarcopenia Is More Prevalent in Men than in Women after Hip Fracture: A Cross-Sectional Study of 591 Inpatients. Archives of Gerontology & Geriatrics, 55, e48-e52. https://doi.org/10.1016/j.archger.2012.05.002
Iellamo, F., Volterrani, M., et al. (2010) Testosterone Therapy in Women with Chronic Heart Failure: A Pilot Double-Blind, Randomized, Placebo-Controlled Study. Journal of the American College of Cardiology, 56, 1310-1316. https://doi.org/10.1016/j.jacc.2010.03.090
Maggiolini, M. and Picard, D. (2010) The Unfolding Stories of GPR30, a New Membrane-Boundestrogen Receptor. Journal of Endocrinology, 204, 105-114. https://doi.org/10.1677/JOE-09-0242
Taaffe, D.R. and Newman, A.B. (2005) Estrogen Replacement, Muscle Composition, and Physical Function: The Health ABC Study. Medicine & Science in Sports & Exercise, 37, 1741-1747. https://doi.org/10.1249/01.mss.0000181678.28092.31
Skjoldebrand, S.L., Kollind, M., et al. (2002) Ovarian Ultrasound and Ovarian and Adrenal Hormones before and after Treatment for Hyperthyroidism. Gynecologic & Obstetric Investigation, 54, 50-55.
https://doi.org/10.1159/000065573
Loric, S., Duron, F., et al. (1989) Testosterone and Its Binding in Hyperthyroid Women before and under Antithyroid Drug Therapy. Acta Endocrinologica, 121, 443-446. https://doi.org/10.1530/acta.0.1210443
Gower, B.A. and Nyman, L. (2000) Associations among Oral Estrogen Use, Free Testosterone Concentration, and Lean Body Mass among Postmenopausal Women. The Journal of Clinical Endocrinology & Metabolism, 85, 4476-4480.
Bian, A.L., Hu, H.Y., et al. (2017) A Study on Relationship between Elderly Sarcopenia and Inflammatory Factors Il-6 and TNF-α. European Journal of Medical Research, 22, 25. https://doi.org/10.1186/s40001-017-0266-9
Goodman, M.J., Ghate, S.R., et al. (2013) Development of a Practical Screening Tool to Predict Low Muscle Mass Using NHANES 1999-2004. Journal of Cachexia, Sarcopenia and Muscle, 4, 187-197. https://doi.org/10.1007/s13539-013-0107-9
