Introduction: Sickle cell
disease (SCD)
is chronic, inherited haemoglobin
disorder, associated with chronic tissue ischemia
which may adversely affect any organ system. Chronic anaemia in SCD results in
cardiac chamber dilatation with compensatory increase in left ventricular mass
and varying degree of diastolic dysfunction that has been a strong independent
predictor of mortality in patients with SCD. There is paucity of
echocardiographic studies on adults Nigerians with SCD. This study therefore,
aimed to assess left ventricular systolic and diastolic function among sickle
cell disease patients in Kano State, North-Western Nigeria. Methods:
The study was cross-sectional
and comparative conducted at the SCD clinic and Medical/outpatient (MOP) clinic of Murtala
Muhammad Specialist Hospital (MMSH), on eligible patients aged 13 years and
above. One hundred patients with SCD (HbSS) were recruited as the study group
while 100 non SCD (HbAA) patients, matched for age and sex served as controls.
Left and right atrial and ventricular dimensions, left ventricular (LV) wall thickness, LV mass
index and LV contractility variables were obtained. Parameters of LV diastolic
function were also evaluated. Results: There were increases in the left atrial
and left ventricular dimensions, left ventricular volumes and left ventricular mass
(LVM) of the SCD patients. LV ejection fraction was equivalent, though there
was evidence of left ventricular diastolic dysfunction in up to 36%. Conclusion: Left
ventricular diastolic dysfunction may complicate cases adults with SCD.
Cite this paper
Saidu, H. , Kabir, A. , Yau, J. A. , Yakasai, A. M. , Abdullahi, U. , Nalado, A. M. and Musa, B. M. (2018). Topic: Echocardiographic Evaluation of Left Ventricular Systolic and Diastolic Function in Nigerians with Sickle Cell Disease. Open Access Library Journal, 5, e4527. doi: http://dx.doi.org/10.4236/oalib.1104527.
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