Background: Infertility has a tendency to become potential
physical and emotional stressors. The current progressive advances in fertility
technology have encouraged more infertile couples to seek for the cause of infertility
and take measures to improve their fertility. It is not uncommon that these couples
experience emotional distress when
they are undergoing fertility treatments. Although it is controversial, some experts argue that this emotional distress affects the
success of fertility programs, such as intrauterine insemination and In vitro fertilization programs. Objective:
The aim of the study was to investigate the relationship between successful pregnancy
and anxiety in patients undergoing intrauterine insemination (IUI) and In vitro fertilization (IVF) programs. Material
and method: A total of 39 patients undergoing intrauterine insemination and In vitro fertilization program
in Aster clinic of Dr. Hasan Sadikin General Hospital during period of September-November
2016 were measured for their anxiety level using Zung Self-Rating Anxiety Scale. The results were then categorized as not anxious (score of 20-44) and anxious
(45-80). Data were then compared against successful pregnancy after each program.
Results: Of 39 patients, 23 underwent IUI and 16 underwent IVF. In the IUI group,
10 patients were not anxious (43.48%) and 13 people were anxious (56.52%) while
in the IVF group 9 were not anxious (56.25%) and 7 were anxious (43.75%). Three
patients (18%) who successfully conceived in the insemination program were those
who were not anxious. Meanwhile, in the IVF group 3 patients (18.8%) also got pregnant
with 2 of them were not anxious and 1 was anxious. A statistical calculation was
performed using Fisher test, resulting in p = 0.068 and p = 1.000 for IUI and IVF,
respectively. Conclusion: There is no significant correlation between the success
of the fertility program and anxiety in patients undergoing IUI and IVF programs.
Cite this paper
Syam, H. H. , Madjid, T. H. , Effendi, J. S. , Djuwantono, T. , Permadi, W. and Fatma, Z. H. (2017). Anxiety Effect in the Success Rate of Intrauterine Insemination (IUI) and In vitro Fertilization (IVF). Open Access Library Journal, 4, e3691. doi: http://dx.doi.org/10.4236/oalib.1103691.
Sharma, S.,
Khinchi, M.P.,
Sharma, N.,
Agrawal, D.
and
Gupta, M.K.
(2011) Female Infertility: An Overview. International
Journal of Pharmaceutical Sciences and Research, 2, 1-12.
Peterson, B.D., Newton, C.R. and
Feingold, T.
(2007) Anxiety and Sexual Stress in Men and Women Undergoing Infertility
Treatment. Fertility and Sterility, 88,
911- 914.
Newton, C.R.,
Sherrard, W.
and
Glavac, I.
(1999) The Fertility Problem Inventory: Measuring Perceived Infertility-Related
Stress. Fertility and Sterility, 72,
54-62.
Kessler, R.C., Chiu, W.T., Demler, O.,
Merikangas, K.R.
and
Walters, E.E.
(2005) Prevalence, Severity, and Comorbidity of 12-Month DSM-IV Disorders in
the National Comorbidity Survey Replication. Archives of General Psychiatry, 62, 617-627. https://doi.org/10.1001/archpsyc.62.6.617
Hashemi, S., Simbar, M., Ramezani-Tehrani, F.,
Shams, J.
and
Majd, H.A.
(2012) Anxiety and Success of In vitro Fertilization. European Journal of Obstetrics
& Gynecology and Reproductive Biology, 164, 60-64. https://doi.org/10.1016/j.ejogrb.2012.05.032
Chiaffarino, F., Baldini, M.P., Scarduelli, C.,
Bommarito, F.,
Ambrosio, S., D’Orsi, C., et al. (2011) Prevalence and Incidence
of Depressive and Anxious Symptoms in Couples Undergoing Assisted Reproductive
Treatment in an Italian Infertility Department. European Journal of Obstetrics & Gynecology and Reproductive
Biology, 158, 235-241. https://doi.org/10.1016/j.ejogrb.2011.04.032
Volgsten, H., SkoogSvanberg, A., Ekselius, L.,
Lundkvist, O.
and
SundstromPoromaa, I.
(2008) Prevalence of Psychiatric Disorders in Infertile Women and Men Undergoing In vitro Fertilization Treatment. Human Reproduction, 23, 2056-2063. https://doi.org/10.1093/humrep/den154
McMahon, C.A., Ungerer, J.A., Beaurepaire, J.,
Tennant, C.
and
Saunders, D.
(1997) Anxiety during Pregnancy and Fetal Attachment after In-Vitro Fertilization Conception. Human Reproduction, 12, 176-182. https://doi.org/10.1093/humrep/12.1.176
Gray, J.D., Tupper, C. and
Rowse, J.A.
(1959) The Problem of Spontaneous Abortion. VII. Prematurity and Spontaneous
Abortion. American Journal of Obstetrics
& Gynecology, 78, 325-332. https://doi.org/10.1016/0002-9378(59)90182-6
Britt, D.W., Risinger, S.T., Mans, M.
and
Evans, M.I.
(2003) Anxiety among Women Who Have Undergone Fertility Therapy and Who Are
Considering Multifetal Pregnancy Reduction: Trends and Implications. The Journal of Maternal-Fetal & Neonatal
Medicine, 13, 271-278. https://doi.org/10.1080/jmf.13.4.271.278
Turner, K., Reynolds-May, M.F., Zitek, E.M.,
Tisdale, R.L.,
Carlisle, A.B.
and
Westphal, L.M.
(2013) Stress and Anxiety Scores in First and Repeat IVF Cycles: A Pilot Study. PLoS ONE, 8, e63743. https://doi.org/10.1371/journal.pone.0063743
Matthiesen, S.M., Frederiksen, Y., Ingerslev, H.J.
and
Zachariae, R.
(2011) Stress, Distress and Outcome of Assisted Reproductive Technology (ART):
A Meta-Anal- ysis. Human Reproduction, 26, 2763-2776. https://doi.org/10.1093/humrep/der246
Boivin, J., Griffiths, E. and
Venetis, C.A.
(2011) Emotional
Distress in Infertile Women and Failure of Assisted Reproductive Technologies:
Meta-Analysis of Prospective Psychosocial Studies. BMJ, 342, d223. https://doi.org/10.1136/bmj.d223
Baldur-Felskov, B., Kjaer, S.K., Albieri, V.,
Steding-Jessen, M.,
Kjaer, T., Johansen, C., et al. (2013) Psychiatric Disorders in
Women with Fertility Problems: Results from a Large Danish Register-Based
Cohort Study. Human Reproduction, 28,
683- 690. https://doi.org/10.1093/humrep/des422
Milad, M.P., Klock, S.C., Moses, S.
and
Chatterton, R.
(1998) Stress and Anxiety Do Not Result in Pregnancy Wastage. Human Reproduction, 13, 2296-2300. https://doi.org/10.1093/humrep/13.8.2296
Demyttenaere, K., Bonte, L., Gheldof, M.,
Vervaeke, M.,
Meuleman, C.,
Vanderschu-erem, D., et al. (1998) Coping Style and
Depression Level Influence Outcome in In vitro Fertilization. Fertility and Sterility,
69, 1026-1033. https://doi.org/10.1016/s0015-0282(98)00089-2
Kokonali, D., Kokonali, M.K., Eroglu, E.
and
Yilmaz, N.
(2015) Is Anxiety an Effective Factor on the Success of Ovulation
Induction/Intrauterine Insemination Cycle? Journal
of Clinical and Analytical Medicine, 6, 770-773.
Smeenk, J.M.,
Verhaak, C.M.,
Eugster, A.,
van Minnen, A.,
Zielhuis, G.A.
and
Braat, D.D.
(2001) The Effect of Anxiety and Depression on the Outcome of In-Vitro Fertilization. Human Reproduction, 16, 1420-1423. https://doi.org/10.1093/humrep/16.7.1420