Adenoviruses (HAdV) serotypes are associated with epidemic respiratory
infections. The aim of this study was to detect HAdV from patients with
respiratory symptoms and typing virus circulating in North of IRAN. Four
hundred nasopharyngeal aspirate samples were obtained from patients with
respiratory symptoms. Clinical data were collected. After DNA extraction, Polymerase Chain Reaction
done for conserved Hexonregion. Positive PCR products were used for sequencing
grouping. 37 cases (9.2%) were positives. Clinical symptoms as cough (73%), body (67/6%),
and fever (64/9%) were found in 35 infected patients (94/5%) and two patients
(15/5%) had no symptoms. All samples were belonged to HAdV of species D
(HAdV-8). Prevalence of respiratory adenovirus infection in our area is consistent with other studies in Iran and ocular type of HAdV8 was the frequent
adenovirus serotype circulating in acute respiratory disease in Golestan
Cite this paper
Javid, N. , Moradi, A. , Mohebbi, A. , Talkhabifard, M. , Kelishadi, M. and Tabarraei, A. (2017). Adenoviruses Type D in Patients with Respiratory Tract Infection Symptoms. Open Access Library Journal, 4, e3624. doi: http://dx.doi.org/10.4236/oalib.1103624.
and Yaghoobi, R.
(2014) Detection of Adenovirus Infection among Children with Acute Respiratory
Disease during 2010- 2012
in Shiraz, Iran. Archives of Pediatric
Infectious Diseases, 2, e15930.
and Arunkumar, G.
(2016) Genotyping of Human Adenoviruses Circulating in Southwest India. VirusDisease, 27, 266-270. https://doi.org/10.1007/s13337-016-0337-5
Grehete, G., et al. (2009) Molecular Characterization of Adenoviral Infections in Cuba:
Report of an Unusual Association of Species D Adenoviruses with Different
Clinical Syndromes. Archives of Virology,
154, 619-627. https://doi.org/10.1007/s00705-009-0338-4
Campos, R., et al. (2005) Molecular Identification of Adenoviruses in Clinical Samples
by Analyzing a Partial Hexon Genomic Region. Journal of Clinical Microbiology, 43, 6176-6182. https://doi.org/10.1128/JCM.43.12.6176-6182.2005
and Sayiner, A.A.
(2015) A 5-Year
Study of Adenoviruses Causing Conjunctivitis in Izmir, Turkey. Journal of Medical Virology, 87, 472-477. https://doi.org/10.1002/jmv.24071
Sheta, A.E., et al. (2014) Molecular Identification of Adenoviruses Associated with
Respiratory Infection in Egypt from 2003 to 2010. BMC Infectious Diseases, 14, 50. https://doi.org/10.1186/1471-2334-14-50
dos Santos, C.,
Alves da Costa, C.
and Hársi, C.M.
(2009) Duplex-PCR Assay for the Detection of Adenovirus and Respiratory Syncytial
Virus in Nasopharyngeal Samples. Memórias
do Instituto Oswaldo Cruz, 104, 118-120. https://doi.org/10.1590/S0074-02762009000100018
(1998) Direct Detection of Respiratory Syncytial Virus, Parainfluenza Virus,
and Adenovirus in Clinical Respiratory Specimens by A Multiplex Reverse
Transcription-PCR Assay. Journal of
Clinical Microbiology, 36, 3149-3154.
and Lee, H.J.
(2005) Rapid Identification of Human Adenovirus Types 3 and 7 from Respiratory
Specimens via Multiplex Type-Specific PCR. Journal
of Clinical Microbiology, 43, 5509-5514. https://doi.org/10.1128/JCM.43.11.5509-5514.2005
Innis, B.L., et al. (2003) Rapid Detection of Adenovirus in Throat Swab Specimens by PCR
during Respiratory Disease Outbreaks among Military Recruits. Journal of Clinical Microbiology, 41,
and Rezaei, F.
(2010) Molecular Detection of Respiratory Viruses in Clinical Specimens from
Children with Acute Respiratory Disease in Iran. The Pediatric Infectious Disease Journal, 29, 931-933.
Shiva, F., et al. (2011) Aetiology of Upper Respiratory Tract Infections in Children
in Arak City: A Community Based Study. Acta
Microbiologica et Immunologica Hungarica, 58, 289-296. https://doi.org/10.1556/AMicr.58.2011.4.5
Pereira Filho, E., et al. (2010) Molecular
Characterization of Adenoviruses from Children Presenting with Acute Respiratory
Disease in Uberlandia, Minas Gerais, Brazil, and Detection of an Isolate Genetically
Related to Feline Adenovirus. Memórias do
Instituto Oswaldo Cruz, 105, 712-716. https://doi.org/10.1590/S0074-02762010000500019
Burton, L., et al. (2009) Characterization of Culture-Positive Adenovirus Serotypes
from Respiratory Specimens in Toronto, Ontario, Canada: September 2007-June
2008. Virology Journal, 6, 11. https://doi.org/10.1186/1743-422X-6-11
and Malasig, M.D.
(2002) Large Epidemic of Respiratory Illness Due to Adenovirus Types 7 and 3 in
Healthy Young Adults. Clinical Infectious
Diseases, 34, 577-582. https://doi.org/10.1086/338471
Metzgar, D., et al. (2009) Outbreak of Severe Respiratory Disease Associated with
Emergent Human Adenovirus Serotype 14 at a US Air Force Training Facility in
2007. Journal of Infectious Diseases,
199, 1419-1426. https://doi.org/10.1086/598520