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UV Visible Spectrophotometric Determination of the Quality of Antiretroviral Drugs Distributed in Kinshasa

DOI: 10.4236/oalib.1102923, PP. 1-8

Subject Areas: Molecular Biology, Biochemistry

Keywords: Spectrophotometry, UV-Visible, ARV, Kinshasa

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Abstract

Background: Antiretrovirals (ARVs) are the molecules used in the fight against infection by the Human Immunodeficiency Virus (HIV). Their main objective is to stop the virus from replicating and thus allow the immune system to recover. In 2001, the program to fight against HIV/AIDS United Nations (UNAIDS) and its partners has decided to strengthen the pharmaceutical channel and improve access to good quality care. Thus ARV quality control is recommended. Objective: The objective of this work was to monitor the quality of ARVs distributed in Kinshasa. Methodology: In this work, UV-visible spectrophotometry is used for the analysis of ARVs presented in simple form distributed in the city of Kinshasa. Results: The results of this work show that the stated and analyzed ARVs contain active ingredients; there is no placebo. Ten percent of these ARVs are non-compliant with regard to dosing of the active test. Conclusion: These results confirm the need to control these drugs to protect patients from adverse consequences related to their poor quality.

Cite this paper

Kamangu, E. N. , Mbinze, J. K. , Mingu, A. M. , Bolavie, J. B. , Mvumbi, G. L. , Kalala, R. L. , Mesia, G. K. , Lusakibanza, M. , Mavar, J. and Marini, R. D. (2017). UV Visible Spectrophotometric Determination of the Quality of Antiretroviral Drugs Distributed in Kinshasa. Open Access Library Journal, 4, e2923. doi: http://dx.doi.org/10.4236/oalib.1102923.

References

[1]  Yeni, P., et al. (2010) Prise en Charge Médicale des Personnes Infectées par le VIH, Rapport. Recommandation du groupe d’experts du Ministère de la Santé et des Solidarités, République Francaise.
[2]  Gross, O. (2006) Programme OMS de pré-qualification des Antirétroviraux, Anti-paludiques et Antituberculeux. Médecine Tropicale, 66, 549-551.
[3]  Habyalimana, V., Kalenda, N., Dispas, A., Mbinze, J.K., Kadima, J.L., Lebrun, P., Hubert, P. and Marini, R.D. (2014) Generic Screening Chromatographic Methods to Fight against Poor Quality Medicines. Spectra Analysis, 298, 30-36.
[4]  Mbinze, J.K., Nsangu, J.M., Maghe, E., Kobo, S., Mwanda, R., Mulumba, G., Bolavie, J.B., Baye-bila, T.M., Borive, M.A., Hubert, Ph. and Marini, R.D. (2015) Application of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines. American Journal of Analytical Chemistry, 6, 106-107. https://doi.org/10.4236/ajac.2015.62010
[5]  Kamangu, N.E., Kalala, N.H. and Mesia, K.G. (2012) Profile of Antiretroviral Treatment Centers in Kinshasa, Democratic Republic of Congo. Proceedings of the 1st Conference of the African Society of Laboratory Medicine, December, Poster 388.
[6]  Kamangu, N.E., Kalala, N.H. and Mesia, K.G. (2014) Analyse des Antirétroviraux distribués à Kinshasa: étude préliminaire. Revue Congolaise des Sciences, 1, 152-159.
[7]  Sarkar, M., Khandavilli, S. and Panchagnula, R. (2006) Development and Validation of RP-HPLC and Ultra Violet Spectrophotometric Methods of Analysis for the Quantitative Estimation of Antiretroviral Drugs in Pharmaceutical Dosage Forms. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 830, 349-354. https://doi.org/10.1016/j.jchromb.2005.11.014
[8]  Anbazhagan, S., Indumathy, N., Shanmugapandian, P. and Sridhar, S.K. (2005) Simultaneous Quantification of Stavudine, Lamivudine and Nevirapine by UV Spectroscopy, Reverse Phase HPLC and HPTLC in Tablets. Journal of Pharmaceutical and Biomedical Analysis, 39, 801-804. https://doi.org/10.1016/j.jpba.2005.04.044
[9]  Sharada, C.H., Channabasavaraj, K.P. and Tamizh Mani, T. (2010) Development of a Spectrophotometric Method for the Quantitative Estimation of Zidovudine Concentration in Bulk and Pharmaceutical Dosage Forms. KMITL Science and Technology Journal, 10, 1-8.
[10]  EuropeanPharmacopoeia 8.0. www.online6.edqm.eu/ep800/
[11]  Traore, A.S. (2005) Mise au point des méthodes d’identification et de dosage des médicaments antirétroviraux au Mali. Thèse doctorale. Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie.
[12]  British Pharmacopoeia. https://www.pharmacopoeia.com
[13]  Buri, P. (1983) Mesure de la vitesse de dissolution pour l’amélioration et le controle de la qualité des médicaments. Journal of Pharmaceutical and Biomedical Analysis, 1, 393-402. https://doi.org/10.1016/0731-7085(83)80054-5
[14]  The International Pharmacopoeia 6th Edition. www.apps.who.int/phint/fr/p/about/

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