All Title Author
Keywords Abstract

Publish in OALib Journal
ISSN: 2333-9721
APC: Only $99

ViewsDownloads

Successful Treatment of a Supralethal Dose Paraquat Poisoning and Follow-Up Report

DOI: 10.4236/oalib.1102118, PP. 1-7

Subject Areas: Toxicology

Keywords: Paraquat Poisoning, Steroids, Ambroxol, Blood Purification

Full-Text   Cite this paper   Add to My Lib

Abstract

Serious exposure to paraquat (more than 10 ml 20% paraquat) usually results in death due to progressive pulmonary fibrosis. We report successful treatment of an 83-year-old male who ingested 50 ml 20% paraquat and the follow-up result after 19 months. Our successful treatment might due to early and enough gastric lavage, superhigh dose of steroids and ambroxol, and early and long process of blood purification. At follow-up, the patient’s general condition, laboratory reports, pulmonary function, and chest radiography remain relatively normal. This successful case suggested that paraquat caused pulmonary fibrosis was reversible, and that paraquat had no long- time side effect to lung, liver, kidney, heart, and marrow if the patient received enough and perfect therapy in time.

Cite this paper

Yuan, F. , Chen, F. , Wang, Y. and Wang, D. (2016). Successful Treatment of a Supralethal Dose Paraquat Poisoning and Follow-Up Report. Open Access Library Journal, 3, e2118. doi: http://dx.doi.org/10.4236/oalib.1102118.

References

[1]  Dong, X.S., Hu, X.B., Liu, W., et al. (2012) Effects of RNA Interference-Induced Smad3 Gene Silencing on Pulmonary Fibrosis Caused by Paraquat in Mice. Experimental Biology and Medicine, 237, 548-555.
http://dx.doi.org/10.1258/ebm.2011.011280
[2]  Li, Q., Peng, X., Yang, H., et al. (2011) Deficiency of Multidrug and Toxin Extrusion 1 Enhances Renal Accumulation of Paraquat and Deteriorates Kidney Injury in Mice. Molecular Pharmaceutics, 8, 2476-2483.
http://dx.doi.org/10.1021/mp200395f
[3]  Mandel, J.S., Adami, H.O. and Cole, P. (2012) Paraquat and Parkinson’s Disease: An Overview of the Epidemiology and a Review of Two Recent Studies. Regulatory Toxicology and Pharmacology, 62, 385-392.
http://dx.doi.org/10.1016/j.yrtph.2011.10.004
[4]  Litteljohn, D., Nelson, E., Bethune, C., et al. (2011) The Effects of Paraquat on Regional Brain Neurotransmitter Activity, Hippocampal BDNF and Behavioural Function in Female Mice. Neuroscience Letters, 502, 186-191.
http://dx.doi.org/10.1016/j.neulet.2011.07.041
[5]  Rappold, P.M., Cui, M., Chesser, A.S., et al. (2011) Paraquat Neurotoxicity Is Mediated by the Dopamine Transporter and Organic Cation Transporter-3. Proceedings of the National Academy of Sciences of the United States of America, 108, 20766-20771.
http://dx.doi.org/10.1073/pnas.1115141108
[6]  Gawarammana, I.B. and Buckley, N.A. (2011) Medical Management of Paraquat Ingestion. British Journal of Clinical Pharmacology, 72, 745-757.
http://dx.doi.org/10.1111/j.1365-2125.2011.04026.x
[7]  Huang, W.D., Wang, J.Z., Lu, Y.Q., et al. (2011) Lysine Acetylsalicylate Ameliorates Lung Injury in Rats Acutely Exposed to Paraquat. Chinese Medical Journal (Engl), 124, 2496-2501.
[8]  Zerin, T., Kim, Y.S., Hong, S.Y., et al. (2012) Protective Effect of Methylprednisolone on Paraquat-Induced A549 Cell Cytotoxicity via Induction of Efflux Transporter, P-Glycoprotein Expression. Toxicology Letters, 208, 101-107.
http://dx.doi.org/10.1016/j.toxlet.2011.10.019
[9]  Zhi, Q.M., Yang, L.T. and Sun, H.C. (2011) Protective Effect of Ambroxol against Paraquat-Induced Pulmonary Fibrosis in Rats. Internal Medicine, 50, 1879-1887.
http://dx.doi.org/10.2169/internalmedicine.50.5407
[10]  Li, Q., Yao, G. and Zhu, X. (2012) High-Dose Ambroxol Reduces Pulmonary Complications in Patients with Acute Cervical Spinal Cord Injury after Surgery. Neurocritical Care, 16, 267-272.
http://dx.doi.org/10.1007/s12028-011-9642-4

Full-Text


comments powered by Disqus

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133

WeChat 1538708413