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Jan 20, 2020Open    AccessArticle

Bromatological Analysis and Antioxidant Capacity of Hibiscus sabdariffa L. in Cuba

Francis Brown, José González, Enrique C. Cejas, Max Monan, Iván S. Sayago
Towards authentication and quality assurance of medicinal plants, calyces of Hibiscus sabdariffa L. recollected from the Experimental Station of Medicinal Plants “Dr Juan Tomas Roig” between January and April 2016 were analyzed to determine its bromatological properties (moisture content; dry matter; fat; protein; total ash; mineral contents) and its antioxidant
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Jun 28, 2019Open    AccessArticle

Hypothesis on Remote Memory Forming from Heterosynaptic LTD-Mediated Neuronal Degeneration

Zi-Jian Cai
In this article, it is hypothesized a new mechanism for the formation of stable remote memory in brain comprising the important memory acquired during childhood and the common words in language. It has been demonstrated that the memory forms concurrently at both homosynaptic long term potentiation (LTP) and heterosynaptic long term depression (LTD). It is pointed out that the repeated LTD may result in neuronal degeneration as evi
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Jun 28, 2019Open    AccessArticle

Flexible Cancer-Associated Chromatin Configuration (CACC) Might Be the Fundamental Reason Why Cancer Is So Difficult to Cure

Gao-De Li
We once proposed that cell-type-associated chromatin configurations determine cell types and that cancer cell type is determined by cancer-associated chromatin configuration (CACC). In this paper, we hypothesize that flexible cell-type-associated chromatin configuration is associated with cell potency and has an advantage over inflexible one in regulating genome related activities, such as DNA replication, DNA tra
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Feb 28, 2019Open    AccessArticle

Formation of Cell-Type-Associated Chromatin Configurations: A Hypothesis

Gao-De Li
More than 30 years ago, we published a hypothesis in which the 3-dimen- sional structure of entire chromatin fibres in a eukaryotic cell is named as chromatin configuration that determines the pattern of gene expression in each type of cell. Based on this hypothesis, cell differentiation is the process in which different types of cells are endowed with different chromatin configura-tions. Therefore, this chrom
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Feb 01, 2019Open    AccessArticle

Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis

Gao-De Li
More than 30 years ago, we published a paper entitled as “Abnormal Chromatin Configuration and Oncogenesis”, which proposed the first hy-pothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many studies have demonstrated that the 3D genome structure plays a major role in oncogenesis, which strongly supports our hypothesis. In this paper, further thoughts about our hypothesis are presented.
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Jun 26, 2018Open    AccessArticle

The Origin of Life Discovered: ΣRNA

Muying Zhou
Since 1992, scientific knowledge has been enough to determine the origin of life: “life originated through RNA”. The truth is that current life world on Earth is just an RNA world, since the protein is created by RNA, then DNA as life’s database is created by RNA along with reverse transcriptase (a protein of RNA making). The two life series on the planet originated through two RNA groups (named ΣRNA ): IΣRNA and IIΣRNA . IΣRNA
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Jan 30, 2018Open    AccessArticle

Characterization of Chitosan Membranes Crosslinked by Sulfuric Acid

Thiago B. Fideles, José Luis Santos, Helena Tomás, Glória T. F. S. Furtado, Daniel B. Lima, Silvia M. P. Borges, Marcus V. L. Fook
Development of novel biomaterials and its practical application have been the subject of much research in the field of scaffolds for tissue engineering, providing the success of producing scaffolds biomaterials that facilitate tissue growth and provide structure support for cells. Due to its biocompatibility and biodegradability, chitosan has been the focus of several researches in recent years to be applied in the
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May 05, 2017Open    AccessArticle

Electronmicroscopic Study of Nanolike Bacteria

Karlen Hovnanyan, Margarita Hovnanyan, Armen Trchounian
Nanobacteria individual cases under the name of suggesting the bacteria mycoplasma and L-transformed forms of bacteria that imitate their size are nanobacteria that a separate systematic units remains controversial; the introduction of new high-resolution analytical microscopy techniques of prokaryote and eukaryote has revealed new structures in the structures of bacteria, which are the target of physical, chemical and biologicall
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Mar 14, 2017Open    AccessArticle

Cell-Cycle-Associated Amplified Genomic-DNA Fragments (CAGFs) Might Be Involved in Chloroquine Action and Resistance in Plasmodium falciparum

Gao-De Li
As a cheap and safe antimalarial agent, chloroquine (CQ) has been used in the battle against malaria for more than half century. However, the mechanism of CQ action and resistance in Plasmodium falciparum remains elusive. Based on further analysis of our published experimental results, we propose that the mechanism of CQ action and resistance might be closely li
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Nov 07, 2016Open    AccessArticle

Is Absence of Spontaneous Agglutinates of Spermatozoa in Semen a Reliable Indicator of Non-Autosensization against Human Sperm Antigens?

Antoine Laudat, Laurence Burc-Struxiano
Objective: Here we compared the results of a prospective study systematically screening for antisperm antibodies in a cohort of subfertile males to the results of a previous retrospective study in equally subfertile patients where screening for antisperm antibodies was performed solely if semen presented spontaneous agglutinates of sperm. Methods: The prospective study was conducted on 317 semen analyses between 1 September 2014 a
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