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Jul 31, 2020Open    AccessArticle

Biomarker Driven Cancer Therapeutics: Existing Tools and Remaining Gaps

Sasi Shanmugam Senga, Jemma Arakelyan
Advancements in technology such as proteomics, genomics have led to the concept of personalized medicine wherein the integration of biomarkers into clinic directs cancer therapeutics. Traditional staging has a stochastic element which can only predict the outcome without actual consideration of intrapatient heterogeneity. In this review, we will look at the biomarkers that prove to be valuable tools for the personalization of cancer therapeutics among lung and breast cancer patients.
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106556


Apr 20, 2020Open    AccessArticle

Orbito-Ethmoidal Rhabdomyosarcoma in an Adult Patient: A Case Report

Nguyen Tien Quang, Pham Tuan Anh, Hoang Thu Hang, Nguyen Phuong Anh
Rhabdomyosarcomas (RMS) is one of the most common sarcomas in children but rare in adults. It can occur in any anatomic location but most often presents in the head and neck region. Herewith, we report a rare case of primary orbito-ethmoidal rhabdomyosarcoma in a 29-year-old female. The patient underwent induction chemotherapy and achieved surprising results.
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106263


Jan 08, 2020Open    AccessArticle

Incidence of Chemotherapy-Induced Amenorrhea in Premenopausal Patients with Breast Cancer Following Adjuvant Chemotherapy with Anthracycline and Taxane

Nguyen Tien Quang, Pham Tuan Anh, Le Van Quang, Nguyen Van Hai, Nguyen Duc Huan, Nguyen Cong Tin, Nguyen Thi Thanh Tam, Hoang Thu Hang, Nguyen Thi Thuy, Do Thi Thanh Mai, Tran Hoang Nam, Le Thi Hanga
Breast cancer (BC) is the second incidence and the fifth leading cause to cancer death in the worldwide. In developing countries, the number of BC cases is still increased annually accompanied with the changes of lifestyle and screening programs. Nevertheless, the majority of BC patients are diagnosed as non-curative stage. Thereby, systemic therapy always plays an important role in BC treatment strategies. Among chemotherapy regi
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Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1105999


Aug 15, 2019Open    AccessArticle

Knowledge of Risk Factors of Health Professionals towards Colorectal Cancer at the Mohammed VI Center of Casablanca for the Treatment of Cancers

Fatima Ezzahra Imad, Houda Drissi, Nezha Tawfiq, Driss Radallah, Karima Bendahhou
Introduction: Colorectal cancer (CRC) is a major public health problem in Morocco. Knowledge of risk factors is the first step in raising awareness. The objective of this work was to evaluate the knowledge of health professionals working at the Mohammed VI center for the treatment of cancers on risk factors of colorectal cancer. Patients and methods: We conducted a cross-sectional, descriptive, exhaustive study of the hospital per
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Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105577


Mar 22, 2019Open    AccessArticle

Therapeutic Effect of Three-Dimensional Conformal Radiotherapy Combined with Tegafur Gimeracil and Oteracil Potassium in the Treatment of Locally Advanced Esophageal Cancer

Xiaoyan Yan, Hongsheng Yu
Objective: To observe the therapeutic effect of three-dimensional conformal radiotherapy combined with Tegafur Gimeracil and Oteracil Potassium in the treatment of locally advanced esophageal cancer. Method: The patients with locally advanced esophageal cancer admitted to our hospital were randomly divided into observation group and control group. The control group was treated with three-dimensional conformal radiotherapy alone; t
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Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105303


Mar 08, 2019Open    AccessArticle

Anti-Tumor Effect and Mechanism of Parthenolide in Gastric Cancer Cellline BGC-823

Wenhao Zhu, Hanni Zhang, Yunliang Guo, Keli Ge, Yonghong Zhou
Objective: To study the anti-tumor effect and mechanism of parthenolide in gastric cancer cell BGC-823. Methods: The cck8 assay was used to detect the changes of BGC-823 cells viability after treatment with different con-centrations of parthenolide at different time points. The proliferation ability of BGC-823 cells was detected by clone formation assay. And the cell cycle and apoptosis were measured by flow cy
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Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105271


Sep 26, 2018Open    AccessArticle

Mucinous Breast Carcinoma: Anatomo-Clinical Radiological and Therapeutic Features

Asma Korbi, Houda Mhabrech, Ennaceur Farouk, Ons Cherif, Amira Daldoul, Chiraz Hafsa, Ahmed Hajji, Raja Faleh
Introduction: Mucinous carcinoma of the breast constitutes 1% to 4% of all breast cancers. Two different forms of presentation are distinguished: pure mucinous carcinoma and mixed mucinous carcinoma. The purpose of our work was to clarify the anatomo-clinical and radiological particularities of this rare form of breast cancer. Materials and methods: This was a retrospective study of a series of 14 cases of mucinous carcinoma of th
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Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104858


Jan 11, 2018Open    AccessArticle

Papillary Carcinoma Arising in Thyroglossal Duct Cyst: A Retrospective Analysis (Cancer of the Thyroid or Primary Cancer of the Thyroglossal Cyst)

Paolo Gamba, Umberto Pignatelli, Giampiero D’Addazio, Gabriella Licursi, Luca Gentile, Ugo Moz
Thyroglossal duct cysts are one of the most common congenital abnormalities of the cervical region. Complications of these swellings are rare, and among these, appearance of a carcinoma has also been noted. Thyroglossal duct cyst carcinoma (TGDC) is a rare entity and its management is controversial. The incidence of thyroid papillary carcinoma in thyroglossal duct cyst is less than 1%, in most cases, the diagnosis is made postoper
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Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104259


Dec 22, 2017Open    AccessArticle

A Rare Collision Tumor: Tracheal Sarcomatoid Carcinoma Invading a Papillary Thyroid Carcinoma

Mofiyinfolu Sokoya, Carissa M. Thomas, Marcia Eustaquio
A collision tumor involving a tracheal sarcomatoid carcinoma and a papillary thyroid carcinoma has never been reported in the literature. A 78-year-old female presented with a large neck mass and hoarseness. A fine needle aspiration demonstrated papillary thyroid carcinoma. Imaging revealed a right thyroid mass invading into the tracheal lumen with bulky ipsilateral lymphadenopathy. The patient underwent a total thyroidectomy, tra
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Open Access Library J. Vol.4, 2017
Doi:10.4236/oalib.1104012


Dec 01, 2017Open    AccessArticle

Primary Neuroendocrine Carcinoma of the Breast: A Case Report and Review of the Literature

H. Bhiri, S. Zaied, H. Mhabrech, I. Abbes, O. Zoukar, H. Bargaoui, A. Korbi, R. Falah, A. Ben Salem, M. Njima, H. Laajili, A. Daldoul
Primary neuroendocrine carcinoma of the breast is a rare tumor that has been considered special features within conventional breast carcinomas until recently. In this article, we present a case report of a 77-year-old woman with a metastatic grade I primary neuroendocrine carcinoma of the breast that has been growing for seven years. The patient was treated with hormone therapy with good outcome.
Open Access Library J. Vol.4, 2017
Doi:10.4236/oalib.1103892


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