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Jan 16, 2019Open    AccessArticle

Brain-Derived Neurotrophic Factor—Major Depressive Disorder and Suicide

Roberto Galea, David Cassar
Objectives: The aims and objectives of this systematic review are to inves-tigate the different theories underlining major depression and suicide while exploring the correlation between BDNF, major depression and suicide. Method: Literature was researched through the University of Malta research platform and statistical reports published by the Maltese National Statistics Office, Eurostat and World Health Org
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Feb 27, 2018Open    AccessArticle

Study on the Interactions of Two Isomer Selaginellins as Novel Small Molecule Inhibitors Targeting PTP1B by Docking and Molecular Dynamics Simulations

Li Wang, Yi Wang, Dan Meng, Honglei Li
Protein Tyrosine Phosphatase 1B (PTP1B) plays a key role in down-regulation of insulin and leptin signaling pathways. Therefore, development of novel inhibitors of PTP1B has becoming research focus in reducing blood sugar levels for Diabetes Mellitus and Obesity. Hence, we selected two isomer Selaginellins (1 and 2) to explain and analyze the binding mechanism of the two potential inhibitors against the PTP1B by molecule docking a
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Nov 13, 2015Open    AccessArticle

Application of Neural Network to Medicine

Bahman Mashood, Greg Milbank
In this article we are going to introduce certain applications of the theory of neural network to medicine. In particular suppose for a given disease D, belonging to the category of immune deficiency diseases or cancers, there are numbers of drugs each with partial remedial effect on D. We are going to formulate a cocktail consisting of mixture of the above drugs with optimal remedial effect on D.


Oct 19, 2015Open    AccessArticle

The Effects of Life Line Facial Cream/Periobitum Serum and Micro-Needling of Photodamaged Skin: A Split-Face Randomized Study

Gordon H. Sasaki
Background: Human growth factors serve as secretomes that regulate skin cell proliferation/differentiation and production of extracellular elements of the matrix and treat photo-aging. Microneedling of skin can also improve aging skin by facilitating normal wound healing of the temporary dermal conduits for therapeutic and cosmetic benefits. Objectives: This open, randomized split-face and single-center controlled study evaluated the safety and efficacy of the application of a cosmeceutical form...


Apr 29, 2015Open    AccessArticle

Micronization of Cetirizine Using Rapid Expansion of Supercritical Carbon Dioxide

Ali Zeinolabedini Hezave, Mostafa Lashkarbolooki, Feridun Esmaeilzadeh
During the past decades, producing micro- and nano-particles of drugs is gaining attention since it is possible to modify the solubility of insoluble drugs in the gastronical fluids significantly. Respect to this fact, in the current investigation, rapid expansion of supercritical carbon dioxide (RESS) for fabricating the micro-particles of cetirizine is investigated. In this way, different operational conditions including extraction pressure (160 - 220 bar), extraction temperature (308 - 328 K)...


Jan 28, 2015Open    AccessArticle

Comprehention of Coils Overlappings Effects —Magnetic Resonance Imaging

Mohammadreza Shiravi Khoozani, Homayoun Meshgin Kelk, Abolfazl Shiravi Khoozani
A typical medical Magnetic Resonance Imaging (MRI) contains a Local transmit/receive coil. Magnetic coil design is very important in study of the human brain and for neurological therapeutics technique. Precise spatial localization of stimulation sites is the key of efficient functional magnetic stimulations. Others have examined this issue at radio frequencies. This paper develops circular coils, figure-of-8 coils and coil array elements in order to realize a transcranial magnetic stimulator, a...


Jan 22, 2015Open    AccessArticle

Access to Essential Medicines in Primary Health Care Units of South Wollo Zone, Ethiopia

Mohammed Hussien, Fikru Tafese
Background: Lack of access to essential medicines is one of the most important public health problems in Ethiopia. The objective of this study was to verify availability, affordability and prices of essential medicines in primary health care units and private medicine outlets of South Wollo Zone. Methods: A facility-based cross-sectional study was undertaken in 10 primary health care units and 10 private medicine outlets. Data were collected through patient exit interview, record review, observa...


Dec 10, 2014Open    AccessArticle

Operations Research Techniques in Management of Samples Transport to the Clinical Laboratory

Ventura Pedret Salvador, Solé Llop Esther, Rovirosa Reverte Monica, Trivino Molla Carmen
Currently, the model is based on the Clinical Laboratory. It is a great centre that performs almost all of the techniques. Thanks to the automation of them. These laboratories receive samples from centres that often are some kilometers away. Time spent between collection and processing must be as short as possible and this is a requirement to care about in order to process the samples in optimal conditions. Transport logistic factor is essential to achieve the right balance between optimal quali...


Aug 28, 2014Open    AccessArticle

Affective Disorders and Antidepressant Drugs

Marc Fakhoury
Affective disorders are a group of psychiatric diseases that can affect an individual at any given age. Also called mood disorders, they can be distinguished into two different types: major depressive disorder, also called major depression, and bipolar disorder, which is known as manic depression. People affected by major depression most often have a low mood, and are consistently in a state of unhappiness. Although it was shown that genetics play a role in the predisposition of depression, this...


Jun 16, 2014Open    AccessArticle

Drug Utilization at Household Level in Nekemte Town and Surrounding Rural Areas, Western Ethiopia: A Cross-Sectional Study

Edao Sado,Teferi Gedif
Background: At household levels drug may be hoarded and re-utilized inappropriately, shared within families and/or outside family and unnecessarily utilized in self-medication. Therefore this study was conducted to assess drug utilization at household level in Nekemte town and surrounding rural areas western Ethiopia. Methods: It was conducted on 844 households’ head through in-terviewing where households were stratified into urban and rural; a household was selected by using systematic random a...


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