OALib 期刊
  OALib Journal (ISSN Print: 2333-9705, ISSN Online: 2333-9721)是一本多合一的开源期刊,以同行评审的方式出版发行文章,其所涵盖的研究领域多达311种领域。本刊发表的全部文章均可在期刊网站上免费阅读、下载、引用和传播。单篇文章出版费用为99美元。详情请咨询[email protected] 或 QQ: 3279437679。现在就去投稿!
               文章 | 目标与领域 | 读者指南 | 编委 | 文章版面费检索             


Go

Dec 29, 2018Open    AccessArticle

Antimicrobial Activities of Syzygium aromaticum (L.) Merr. and L.M. Perry (Myrtaceae) Fruit Extracts on Six Standard Microorganisms and Their Clinical Counterpart

Y.-G. Afanyibo, K. Anani, K. Esseh, Y. Sadji, K. Idoh, K. Koudouvo, A. Agbonon, Y. Améyapoh, K. Tozo, M. Gbeassor
Syzygium aromaticum is used in combination with other plants as an al-coholic infusion by traditional practitioners to treat infections. It has been selected for evaluation for its antimicrobial properties to justify its use in traditional pharmacopoeia. The fruits were used as plant material while the microbial germs consisted of six reference strains: Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Salmonella typh
...


Oct 26, 2018Open    AccessArticle

Pharmacognostical, Phytochemical and Antioxidant Evaluations of Guettarda calyptrata A. Rich.

Yamilet Irene Gutiérrez Gaitén, José González Yaque, Ramón Scull Lizama, Zuleira Ocanto Torres, Alejandro Felipe González, José Luis Mayoral Jiménez, Max Monan
Guettarda calyptrata A. Rich., originally from Cuba and known as “Contraguao”, has traditionally been used to counteract quickly and effectively burns produced by Comocladia dentate Jacq (Guao), vegetable species that secretes a highly caustic latex for skin and mucous membranes. A burn is a traumatic injury resulting in local and
...


Jun 06, 2018Open    AccessArticle

Bioequivalence of 150 mg Extended-Release Ketoprofen from Laboratories LETI S.A.V. Test, vs ProfenidBI of Laboratories Sanofi-Aventis Pharmaceuticals LTDA, Prolonged Release, Reference, in Healthy Volunteers*

Maria A. Annunziato, Maria Gonzalez Yibirin, Inatti Alfredo, Maria M. Soler
Objective: To evaluate the bioequivalence between two formulations of ketoprofen after administration of a 150 mg extended release tablet (L.P. ProfenidBI?), 150 mg modified release tablets. Methods: A single-dose cross-over, randomized study was performed under fasting conditions with two treatments, two periods, two
...


Feb 28, 2018Open    AccessArticle

Ciprofloxacin Hydrochloride Encapsulated into PLGA Nanoparticles for Drug Delivery Application: Fractional Factorial Design

Tajudeen Adebileje, Sikiru Adebileje, P. O. Aye
Over several decades, poly (lactic-co-glycolic acid) (PLGA) have been widely used as Micro-and Nano-carriers of therapeutic agents for drug delivery applications. However, encapsulation process of therapeutic agents into PLGA Nanoparticles (NPs) necessitates a defined step to understand the effects and interactions of parameters involved in production process. In pharmaceutics formulations, compared to
...


Feb 27, 2018Open    AccessArticle

Study on the Interactions of Two Isomer Selaginellins as Novel Small Molecule Inhibitors Targeting PTP1B by Docking and Molecular Dynamics Simulations

Li Wang, Yi Wang, Dan Meng, Honglei Li
Protein Tyrosine Phosphatase 1B (PTP1B) plays a key role in down-regulation of insulin and leptin signaling pathways. Therefore, development of novel inhibitors of PTP1B has becoming research focus in reducing blood sugar levels for Diabetes Mellitus and Obesity. Hence, we selected two isomer Selaginellins (1 and 2) to explain and analyze the binding mechanism of the two potential inhibitors against the PTP1B by molecule docking a
...


Nov 13, 2017Open    AccessArticle

Escherichia coli Resistance to Ciprofloxacin in Acute Uncomplicated Pyelonephritis

Emad Abu Sitta, Nour Aljariri Alhesan, Babikir Kheiri, Sunil Badami, Farah Elounais, Omar Assassa, Maneesh Gaddam, Carlos Rios-Bedoya
Background: Severe acute uncomplicated pyelonephritis is an infection of the kidneys that usually have an ascending route and occur in presumably healthy urinary tract. The most common pathogen involved is E. coli. The Infectious Diseases Society of America (IDSA) has issued an updated guideline in 2010 suggesting IV quinolones to be considered in the initial em
...


Nov 09, 2017Open    AccessArticle

Investigation of Contributing Factors to Scombroid Fish Poisoning among Dar es Salaam City Residents in Tanzania

Ngwengwe Bulula, Veronica Mugoyela, Eliangiringa Kaale
Scombroid fish poisoning is a mild to moderate form of food poisoning caused by eating spoiled or bacterial contaminated fish after capture or during subsequent handling and storage. Its symptoms are similar to those of fish allergy though it gives negative results to allergy tests. Because of that, most clinicians misdiagnose scombroid or histamine fish poisoning, and erroneously advise their
...


Aug 12, 2016Open    AccessArticle

Qualitative and Quantitative Study on the Suppository of Penyankang

Linli Xia, Xiehe Wang, Congying Wang, Ying Song
Objective: To establish the quality standard for Penyankang Suppository. Method: Thin Layer Identification (TLC) was used for the qualitative identification of Caulis Sargentodoxae, Radix Salviae Miltiorrhizae, Rhizoma Corydalis and Rhizom Sparganii. High performance liquid chromatography (HPLC) was used to determine the contents of salvianolic acid B and tetrahydropalmatine. Results: Thin Layer Identification (TLC) spots were cle
...


Jan 05, 2016Open    AccessArticle

Phytochemical Investigation of Antimicrobial and Antioxidant Activity Leaves Extracts of Corchorus olitorius

Rehab Mobark Osman Mohammed
The leaves extracts of Corchorus olitorius, the family Malvaceae, are commonly called khudra, the plant extensively used in Sudanese traditional medicine. The Sudanese varieties are one of the best in the market, which prompted investigation of leaves extracts. Some chemical analyses of the leaves have been done such as determination of ash content and trace elements (Ca, Fe, Mg, and Na) by atomic absorption spectrometry. The 96% ethanolic, Ethyl acetate and chloroform extracts exh...


Dec 07, 2015Open    AccessArticle

Effect of EGb761 on the Dynamic Changes of Energy Metabolites and Bio-Metal in the Brain Cortex of Gerbil during Focal Cerebral Ischemia

Ming-Cheng Lin
The aim of this study was to evaluate the pharmacological effect of EGb761 on the dynamic alterations of magnesium (Mg) and energy metabolites including glucose and lactate in brain cortex of gerbil during focal cerebral ischemia. A single dose of EGb761 (100 mg/kg, i.p.) was given 30 min prior to cerebral ischemic surgery. Cerebral ischemia was induced by occlusion of the right middle cerebral artery (RMCA) for 180 minutes. Two microdialysis probes were stereotaxically implanted bilaterally int...


Go