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以半夏泻心汤为主方加减治疗慢性萎缩性胃炎的临床有效率评价
赵燕明，北京紫竹桥中医医院, 北京，100049
中外临床医学 , DOI: 10.12479/questpress-zwlcyx.20250222
Abstract: 目的 探讨慢性萎缩性胃炎临床治疗中应用以半夏泻心汤为主方加减治疗的效果与价值。方法 观察对象为80例前来我院就诊的慢性萎缩性胃炎患者，收集时间为2021年8月至2025年6月，依照随机数字表法将其分成两组，40 例设定为对照组，本组予以常规西药治疗，40 例设定为研究组，本组的西药治疗方式与对照组相同，同时予以以半夏泻心汤为主方加减治疗，两组患者就临床症状积分改善情况、治疗效果、血清炎症因子水平变化、胃黏膜组织病理评分、不良反应发生率等展开统计比较。结果 两组之间进行比较，治疗前嗳气、胀满、脘腹痛等临床症状积分及IL-6、IL-8、TNF-α等血清炎症因子水平及胃黏膜组织病理评分的差异并不大，无统计学意义，P ＞ 0.05；治疗后，研究组临床症状积分、血清炎症因子水平及腺体萎缩、活动度、异型增生黏膜炎症、肠上皮化生等胃黏膜组织病理评分全部低于对照组，且全部存在统计学差异，P ＜ 0.05；研究组患者的临床治疗总有效率较对照组高，同时其不良反应发生率较对照组低，组间出现的差异具备统计学意义，P ＜ 0.05。结论 选择以半夏泻心汤为主方加减治疗的方式有利于快速改善慢性萎缩性胃炎患者的临床症状与胃黏膜组织病理状态，同时进一步降低炎症因子的影响，切实提高临床疗效与安全性，值得作为理想的治疗方法在临床中积极推广。
夏苍和胃颗粒剂治疗慢性萎缩性胃炎的网络药理学研究及分子对接验证
Network Pharmacology Study and Molecular Docking Validation of Xia Cang He Wei Granules in the Treatment of Chronic Atrophic Gastritis  [PDF]
于盈, 王欣怡, 张汇升, 吕晶, 刘彬, 王晓, 张丽平
Pharmacy Information (PI) , 2023, DOI: 10.12677/PI.2023.124037
Abstract: 本文采用网络药理学方法和分子对接技术对夏苍和胃颗粒剂治疗慢性萎缩性胃炎(chronic atrophyic gastritis, CAG)的作用机制进行探讨。通过在线数据库挖掘筛选得到颗粒剂的主要活性成分作用的潜在靶点以及CAG相关的疾病靶点。在筛选得到颗粒剂与疾病的交集基因的基础上构建“疾病–中药–主要成分–关键靶点(基因)”网络关系以及PPI互作网络。并且进行GO富集分析和KEGG通路分析，利用Auto Dock Vina软件进行进一步分子对接验证。最终筛选得到颗粒剂217种活性成分、275个相关靶点以及818种疾病基因。取交集筛选得到药物–疾病交集靶点100个，通过PPI蛋白互作分析得到颗粒剂治疗CAG可能与AKT1、TP53、IL6、TNF、VEGFA、CASP3等靶点有关。GO富集分析涉及434条注释，KEGG富集分析得到191条相关信号通路信息。分子对接发现木犀草素与TP53、IL6的对接活性最高。本文利用网络药理学方法和分子对接技术验证了夏苍和胃颗粒剂能够通过多种组分、多个靶点、多条通路对CAG起到治疗作用，为进一步改良药物提高疗效提供依据和有益参考。
The mechanism of action of Xia Cang He Wei Granules in the treatment of chronic atrophic gastritis (CAG) was examined in this study using network pharmacology and molecule docking approaches. Online database mining screening was used to identify illness targets connected to CAG as well as possible candidates for the major active components of granules. On the basis of screening the intersection genes between granules and diseases, the network relationship of “disease-herb-main component-key target (gene)” and PPI interaction network were constructed. And GO enrichment analysis and KEGG pathway analysis were performed, and further molecular docking validation was performed using Auto Dock Vina software. Finally, 217 active components, 275 related targets and 818 disease genes of granules were screened. A total of 100 targets of drug-disease intersection were obtained by intersection screening, and PPI protein interaction analysis showed that the treatment of CAG with granules may be related to AKT1, TP53, IL6, TNF, VEGFA, CASP3 and other targets. GO enrichment analysis involved 434 annotations, and KEGG enrichment analysis yielded 191 relevant signaling pathway information. Molecular docking revealed that luteolin had the highest docking activity with TP53 and IL6. In this paper, network pharmacology and molecular docking techniques were used to verify that Xia Cang He Wei Granules could play a therapeutic role in CAG through a variety of components, multiple targets, and multiple pathways, providing a basis and useful reference for further improving the efficacy of drugs.
半夏泻心汤加味治疗慢性萎缩性胃炎60例临床观察
尤金亮,尤俊文
宁夏医科大学学报 , 2007,
Abstract: 为观察半夏泻心汤加味治疗慢性萎缩性胃炎(CAG)的疗效,将确认为CAG的患者随机分为治疗组(运用半夏泻心汤加味治疗)和对照组(摩罗丹治疗),用药6个月后做对照观察。结果,总有效率治疗组93.3%,对照组73.3%,两组比较差异有统计学意义(P<0.05),治疗组对胃黏膜腺体萎缩改善作用明显优于对照组(P<0.05)。表明半夏泻心汤加味治疗慢性萎缩性胃炎疗效较佳。更多还原
王捷虹教授运用半夏泻心汤治疗慢性萎缩性胃炎经验总结
莹王捷虹
- , 2017,
Abstract: 王捷虹教授一直从事慢性萎缩性胃炎的研究，认为慢性萎缩性胃炎病机多属于本虚标实之证。其致病多因湿热之邪，蕴结于胃，灼伤胃阴，阴液不足，胃黏膜腺体失养，故出现腺体萎缩、黏膜变薄；气阴两虚日久致胃络瘀阻，瘀久则出现肠化、增生，临床主张用辛开苦降之半夏泻心汤加减治疗CAG，往往取得较好的疗效
半夏泻心汤治疗慢性萎缩性胃炎探析
桂越蓉,王捷虹
- , 2018,
Abstract: 慢性萎缩性胃炎是胃癌的癌前疾病，因此积极治疗慢性萎缩性胃炎是防止其进一步进展为胃癌的 关键环节。结合文献分析了慢性萎缩性胃炎的病因、病机及治疗原则，认为半夏泻心汤治疗慢性萎缩性胃炎除 属寒热错杂型外，也可用于治疗脾虚气滞，湿热中阻型慢性萎缩性胃炎，临床取得良好疗效，值得临床借鉴与 应用
中西医结合治疗慢性萎缩性胃炎64例疗效观察
罗明玉
- , 2012,
Abstract: 目的 观察西药配合健脾温中汤加减治疗慢性萎缩性胃炎的临床疗效。方法 将128例患者随机分为2组,对照组64例给予奥美拉唑肠溶胶囊、阿莫西林胶囊口服治疗;治疗组64例在对照组治疗方法的基础上给予自拟健脾温中汤加减治疗。2组均以1月为1个疗程,3个疗程后判定疗效。结果 治疗组总有效率为92.19%,对照组为70.31%,2组比较差异有高度统计意义(P<0.01)。结论 西药配合自拟健脾温中汤加减治疗慢性萎缩性胃炎疗效显著,值得推广
泻心汤类经方治疗慢性萎缩性胃炎的临床研究进展
Clinical Research Progress of Xiexin Decoction in Treating Chronic Atrophic Gastritis  [PDF]
李梦圆, 赵睿
Advances in Clinical Medicine (ACM) , 2023, DOI: 10.12677/ACM.2023.13122688
Abstract: 张仲景的《伤寒论》中记载了多种泻心汤类经方，包含半夏泻心汤、生姜泻心汤、甘草泻心汤、附子泻心汤、大黄黄连泻心汤等，临床惯用于寒热互结于胃脘所致的“心下痞”。泻心汤类经方组方严密、药味精简，以半夏泻心汤进行灵活配伍，临床运用广泛。本文将主要论述近代医家运用泻心汤类经方治疗慢性萎缩性胃炎的临床进展及作用机制，以期为经方广泛运用于临床提供更多的医学证据。相关研究表明，泻心汤类经方在杀灭幽门螺旋杆菌、增强机体免疫力、保护胃肠黏膜、缓解患者临床症状等方面具有显著作用。
Zhang Zhongjing’s Treatise on Febrile Diseases recorded a variety of classic prescriptions of Xiexin Decoction, including Banxia Xiexin Decoction, Ginger Xiexin Decoction, Glycyrrhiza Xiexin Decoction, Fuzi Xiexin Decoction, Dahuang Huanglian Xiexin Decoction, etc., which are mostly used for “heart-swelling” caused by the combination of cold and heat in the stomach. Xiexin decoction has strict prescription and concise medicine taste, and is flexibly compatible with Banxia Xiexin decoc-tion, which is widely used in clinic. This article will mainly discuss the clinical progress and mecha-nism of modern physicians in treating chronic atrophic gastritis by using the classic prescriptions of Xiexin decoction, in order to provide more medical evidence for the wide application of the classic prescriptions in clinic. Relevant research shows that Xiexin decoction has significant effects in kill-ing Helicobacter pylori, enhancing immunity, protecting gastrointestinal mucosa and relieving clin-ical symptoms of patients.
马卫平治疗慢性胃炎合并焦虑抑郁经验
满春艳
- , 2019,
Abstract: 慢性胃炎合并焦虑抑郁，临床高发，症状反复发作，相互影响。马卫平主任中医师治疗此病颇有心得，认为本病的主要病机为脾胃升降失常，肝郁气滞，痰瘀互结；治以升清降浊、疏肝行气、化痰活血法；选用半夏泻心汤合用癫狂梦醒汤辨治，取得显著临床疗效
半夏泻心汤联合西医治疗慢性胃炎５９例
刘利新,张可训
- , 2019,
Abstract: 目的分析探讨半夏泻心汤联合常规西医治疗幽门螺杆菌感染性慢性胃炎的疗效?方法选取我院于2016年12月~2018年12月期间收治的118例慢性胃炎患者,并将其随机分配到治疗组和对照组两组,两组患者均给予西医三联疗法进行治疗,而治疗组在此治疗基础上联合使用中医半夏泻心汤进行治疗?在治疗结束后分别对两组患者使用14C-尿素呼吸试验联合快速尿素酶试验检查其幽门螺杆菌感染情况,并且采用胃镜检查患者的恢复情况?结果治疗组和对照组的总有效率分别为96.61%和83.05%,两组数据比较差异具有统计学意义(χ2=5.8
加味半夏泻心汤联合四联治疗脾胃湿热型幽门螺杆菌相关性慢性胃炎40例临床疗效观察
Observation on the Clinical Efficacy of Added Banxia Xiexin Decoction and Quadruple Drug Therapy in the Treatment of 40 Cases of Chronic Gastritis Associated with Hp-Related Chronic Gastritis with Spleen Stomach Damp  [PDF]
程寒, 谭正玉, 邹体强, 邹景宇, 程秀丽, 饶秋霞, 金锐, 方能能
Traditional Chinese Medicine (TCM) , 2025, DOI: 10.12677/tcm.2025.141036
Abstract: 目的：探究加味半夏泻心汤联合四联疗法治疗幽门螺杆菌(Hp)相关性慢性胃炎脾胃湿热型的临床疗效。方法：将2022年7月~2024年7月随州市中医医院脾胃病科科诊治的40例Hp感染后脾胃湿热型慢性胃炎患者作为研究对象，随机将研究对象分为对照组(四联疗法)和研究组(四联疗法合用加味半夏泻心汤)，每组各20例。观察两组患者临床症状治疗有效率、Hp根除率及中医证候积分的变化情况。结果：研究组(四联疗法合用加味半夏泻心汤组)证候治疗有效率、Hp根除率均高于对照组(四联疗法组)，差异有统计学意义(P < 0.05)；研究组(四联疗法合用加味半夏泻心汤组)上述指标均低于对照组(四联疗法组)，差异有统计学意义(P < 0.05)。结论：在Hp相关性脾胃湿热型慢性胃炎的治疗中，加味半夏泻心汤联合四联疗法能更好地根除Hp，能快速改善患者相关临床证候，提高其日常生活质量，经济高效，疗效可靠。
Objective: To explore the clinical efficacy of modified Banxia Xiexin Tang combined with quadruple therapy in the treatment of Helicobacter pylori (Hp)-related chronic gastritis with spleen stomach damp heat type. Methods: Forty patients with chronic gastritis of spleen and stomach damp heat type after Hp infection treated by the type of Spleen and Stomach Diseases from July 2022 to July 2024 were selected as the study subjects. The study subjects were randomly divided into a control group (quadruple therapy) and a study group (quadruple therapy combined with modified Banxia Xiexin Tang), with 20 cases in each group. Observe the changes in the effective rate of clinical symptom treatment, Hp eradication rate, and TCM syndrome score between two groups of patients. Results: The treatment efficacy and Hp eradication rate of the research group (the combination of quadruple therapy and modified Banxia Xiexin Tang group) were higher than those in the other one (the quadruple therapy group); The above indicators in the research group (the combination of quadruple therapy and modified Banxia Xiexin Tang group) were lower than those in the other group (quadruple therapy group), the difference was statistically significant (P < 0.05). Conclusion: In the treatment of Hp related spleen stomach damp heat chronic gastritis, the combination of modified Banxia Xiexin Tang and quadruple therapy can better eradicate Hp, rapidly improve patients' relevant clinical symptoms, enhance their quality of life, and have reliable therapeutic effects. It is recommended for application.
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