Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations

a spectrophotometric method based on the formation of ion-pair complex between haloperidol and eriochrome black t (ebt) at ph 1.85 has been described. the formed complex was extracted quantitatively into chloroform and measured at 510 nm. infra red (ir) studies were performed to confirm the formation of ion-pair complex. beer's law was obeyed in the concentration range of 2.0-9.0 μg ml-1 with molar absorptivity of 2.67 × 104 l mol-1 cm-1. the detection limit was found to be 0.18 μg ml-1. statistical comparison of the results of the proposed method with those of the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.