%0 Journal Article
%T Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations
%A Rahman
%A Nafisur
%A Khatoon
%A Asma
%A Rahman
%A Habibur
%J Qu¨ªmica Nova
%D 2012
%I Sociedade Brasileira de Qu¨ªmica
%R 10.1590/S0100-40422012000200028
%X a spectrophotometric method based on the formation of ion-pair complex between haloperidol and eriochrome black t (ebt) at ph 1.85 has been described. the formed complex was extracted quantitatively into chloroform and measured at 510 nm. infra red (ir) studies were performed to confirm the formation of ion-pair complex. beer's law was obeyed in the concentration range of 2.0-9.0 ¦̀g ml-1 with molar absorptivity of 2.67 ¡Á 104 l mol-1 cm-1. the detection limit was found to be 0.18 ¦̀g ml-1. statistical comparison of the results of the proposed method with those of the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.
%K haloperidol
%K ion-pair complex
%K spectrophotometry.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-40422012000200028&lng=en&nrm=iso&tlng=en