Mst1-FoxO Signaling Protects Na？ve T Lymphocytes from Cellular Oxidative Stress in Mice

The Ste-20 family kinase Hippo restricts cell proliferation and promotes apoptosis for proper organ development in Drosophila. In C. elegans, Hippo homolog also regulates longevity. The mammalian Ste20-like protein kinase, Mst1, plays a role in apoptosis induced by various types of apoptotic stress. Mst1 also regulates peripheral na？ve T cell trafficking and proliferation in mice. However, its functions in mammals are not fully understood.