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A reduced dose of darunavir/ritonavir is effective in PI-experienced HIV-infected patients

DOI: 10.1590/S1413-86702011000500017

Keywords: hiv infections, pharmacokinetics antiretroviral therapy, highly active.

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Abstract:

darunavir (drv) is an hiv-1 protease inhibitor that is used together with a low boosting dose of ritonavir as part of an antiretroviral therapy (art) regimen in treatment-experienced and na?ve hivpositive patients. in na?ve and experienced patients with no drv-mutations, drv is licensed at the dose of 800 mg plus 100 mg of ritonavir once daily. we report our results in seven art-experienced hiv-infected patients, in whom a reduced dose of darunavir/ritonavir (600/100 mg once daily) successfully controlled viral replication

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