Eficácia do latanoprosta x travoprosta avaliada pela curva diária de press？o intraocular

purpose: to assess the efficacy of latanoprost (l) and travoprost (t) as monotherapy as well as both drugs associated with 0.5% timolol maleate twice a day regarding the daily curve of intraocular pressure (dcpo) with the measurement of intraocular pressure (iop) at 6 am in bed. methods: retrospective study analyzing the daily curve of intraocular pressure of patients treated with l or t with or without 0.5% tim. patients who did not correctly follow the treatment were excluded. we also excluded the patients who used the prostaglandin analog associated with any other antiglaucomatous drug different from 0.5% tim and those who were treated with more than two antiglaucomatous drugs. statistical analysis was made through the spss 11.0 program calculating mean intraocular pressure (pm), variability (v), p value and standard deviation. ethnic aspects or type of glaucoma were no criteria of inclusion or exclusion in this study. results: seventy-five patients (142 eyes) were included. the average age was 61.7 years. thirty-three (44.0%) patients were male and 42 (56.0%) were female. thirteen patients (26 eyes 18.3%) used l, 18 patients (33 eyes - 23.2%) were treated with t, 18 patients (32 eyes - 22.5%) used latanoprost and 0.5% timolol (l 0.5%tim) and 26 patients (51 eyes - 35.9%) used travoprost and 0.5% timolol (t 0.5%tim). chronic simple glaucoma was the most common type (92.0%), followed by congenital glaucoma (6.7%) and glaucoma secondary to cataract surgery (1.3%). pm was 15.2 (± 4.2) mmhg among those treated with l and 14.8 (± 3.2) mmhg among the t users. those patients showed a v of 2.0 (± 1.2) and 3.2 (± 1.9). in the group of l 0.5%tim and t 0.5%tim the pm and v were 14.9 (± 2.2) mmhg, 15.0 (± 3.2) mmhg, 2.4 (± 1.2) and 2.8 (± 1.6) respectively. no statistical significant difference was found in the pm neither with the drugs used as monotherapy nor with them associated with 0.5% timolol maleate as well as in the v with both drugs associated with 0.5% timolol male