%0 Journal Article
%T Efic¨¢cia do latanoprosta x travoprosta avaliada pela curva di¨¢ria de press£¿o intraocular
%A Santos
%A H¨¦rika Danielle de Miranda
%A Fernandes
%A Thatiana Almeida Pereira
%A Souza
%A Camila Ara¨²jo de
%A Cronemberger
%A Sebasti£¿o
%A Calixto
%A Nassim
%J Arquivos Brasileiros de Oftalmologia
%D 2009
%I Conselho Brasileiro de Oftalmologia
%R 10.1590/S0004-27492009000100003
%X purpose: to assess the efficacy of latanoprost (l) and travoprost (t) as monotherapy as well as both drugs associated with 0.5% timolol maleate twice a day regarding the daily curve of intraocular pressure (dcpo) with the measurement of intraocular pressure (iop) at 6 am in bed. methods: retrospective study analyzing the daily curve of intraocular pressure of patients treated with l or t with or without 0.5% tim. patients who did not correctly follow the treatment were excluded. we also excluded the patients who used the prostaglandin analog associated with any other antiglaucomatous drug different from 0.5% tim and those who were treated with more than two antiglaucomatous drugs. statistical analysis was made through the spss 11.0 program calculating mean intraocular pressure (pm), variability (v), p value and standard deviation. ethnic aspects or type of glaucoma were no criteria of inclusion or exclusion in this study. results: seventy-five patients (142 eyes) were included. the average age was 61.7 years. thirty-three (44.0%) patients were male and 42 (56.0%) were female. thirteen patients (26 eyes 18.3%) used l, 18 patients (33 eyes - 23.2%) were treated with t, 18 patients (32 eyes - 22.5%) used latanoprost and 0.5% timolol (l 0.5%tim) and 26 patients (51 eyes - 35.9%) used travoprost and 0.5% timolol (t 0.5%tim). chronic simple glaucoma was the most common type (92.0%), followed by congenital glaucoma (6.7%) and glaucoma secondary to cataract surgery (1.3%). pm was 15.2 (¡À 4.2) mmhg among those treated with l and 14.8 (¡À 3.2) mmhg among the t users. those patients showed a v of 2.0 (¡À 1.2) and 3.2 (¡À 1.9). in the group of l 0.5%tim and t 0.5%tim the pm and v were 14.9 (¡À 2.2) mmhg, 15.0 (¡À 3.2) mmhg, 2.4 (¡À 1.2) and 2.8 (¡À 1.6) respectively. no statistical significant difference was found in the pm neither with the drugs used as monotherapy nor with them associated with 0.5% timolol maleate as well as in the v with both drugs associated with 0.5% timolol male
%K glaucoma [drug therapy]
%K intraocular pressure
%K prostaglandins f
%K synthetic [therapeutic use]
%K antihypertensive agents [therapeutic use]
%K cloprostenol [therapeutic use]
%K timolol [therapeutic use]
%K drug combination
%K time factors.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27492009000100003&lng=en&nrm=iso&tlng=en